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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo1decreases acetylationEXP 6480464CTDEthanol results in decreased acetylation of FOXO1 proteinPMID:23544086
Foxo1decreases phosphorylationEXP 6480464CTDEthanol results in decreased phosphorylation of FOXO1 proteinPMID:29940154
Foxo1multiple interactionsEXP 6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of FOXO1 protein]; [Dietary Fats co-treated with Ethanol] results in increased expression of FOXO1 mRNA; ursodoxicoltaurine inhibits the reaction [Ethanol results in decreased acetylation of FOXO1 protein]PMID:23544086 PMID:24275070 PMID:29940154
Foxo1affects splicingISOFoxo1 (Mus musculus)6480464CTDEthanol affects the splicing of FOXO1 mRNAPMID:30319688
Foxo1decreases phosphorylationISOFOXO1 (Homo sapiens)6480464CTDEthanol results in decreased phosphorylation of FOXO1 proteinPMID:29940154
Foxo1increases acetylationISOFoxo1 (Mus musculus)6480464CTDEthanol results in increased acetylation of FOXO1 proteinPMID:20007851
Foxo1multiple interactionsISOFOXO1 (Homo sapiens)6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of FOXO1 protein]PMID:29940154
Foxo1multiple interactionsISOFoxo1 (Mus musculus)6480464CTD[Resveratrol co-treated with Ethanol] results in increased expression of FOXO1 mRNA; Ethanol results in increased phosphorylation of and affects the localization of FOXO1 protein; FOXO1 protein inhibits the reaction [Ethanol results in increased expression of TXNIP protein]; PPP2CA protein inhibits the reaction [Ethanol results in increased phosphorylation of FOXO1 protein]; Rosiglitazone inhibits the reaction [Ethanol results in increased acetylation of FOXO1 protein]PMID:18755807 PMID:20007851 PMID:32492475
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