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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo1multiple interactionsISOFOXO1 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of and results in increased acetylation of FOXO1 proteinPMID:29545174
Foxo1multiple interactionsISOFoxo1 (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]PMID:25665036
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