| 11491 | Wnt1 | wingless-type MMTV integration site family, member 1 | Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and embryonic brain development. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 98687738 | 98691711 | Mouse | 341 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344355 | WNT1 | Wnt family member 1 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] | 12 | 48978322 | 48982620 | Human | 391 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1597195 | Wnt1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (ortholog); protein domain specific binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN animal organ regeneration; cellular response to peptide hormone stimulus; hepatocyte differentiation; PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular region (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 4-nitroquinoline N-oxide; 6-propyl-2-thiouracil | 7 | 131817558 | 131821605 | Rat | 258 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9038218 | Wnt1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (ortholog); protein domain specific binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte-dopaminergic neuron signaling (ortholog); bone development (ortholog); PARTICIPATES IN Wnt signal ing pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular region (ortholog) | NW_004955500 | 7797063 | 7811142 | Chinchilla | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11751396 | WNT1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein domain specific binding (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPAT ES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | 12 | 39767839 | 39772460 | Bonobo | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12203558 | WNT1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); protein domain specific binding (inferred); receptor ligand activity (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PA RTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | 27 | 5588151 | 5592254 | Dog | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12615678 | Wnt1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein domain specific binding (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPAT ES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | NW_004936512 | 6781001 | 6785358 | Squirrel | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13867597 | WNT1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); protein domain specific binding (inferred); receptor ligand activity (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PA RTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | | | | Pig | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18382871 | WNT1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein domain specific binding (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPAT ES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | | | | Green Monkey | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917942 | Wnt1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein domain specific binding (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPAT ES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred) | | | | Naked Mole-Rat | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246521 | wnt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625942714 | Wnt1 | Wnt family member 1 | ENCODES a protein that exhibits cytokine activity (ortholog); protein domain specific binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte-dopaminergic neuron signaling (ortholog); bone development (ortholog); PARTICIPATES IN Wnt signal ing pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); BCARD syndrome (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular region (ortholog) | | | | Black Rat | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251978 | wnt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256770 | wnt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1312745 | Wnt10b | wingless-type MMTV integration site family, member 10B | Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-temp lated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; jaw; nervous system; and surface ectoderm. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 98668593 | 98676093 | Mouse | 188 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733304 | Wnt2b | wingless-type MMTV integration site family, member 2B | Predicted to enable cytokine activity and frizzled binding activity. Involved in forebrain regionalization. Acts upstream of or within several processes, including canonical Wnt signaling pathway; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predic ted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 104852121 | 104869025 | Mouse | 147 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312798 | Wnt9a | wingless-type MMTV integration site family, member 9A | Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of chondrocyte differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; craniocervical region bone; limb; reproductive system; and urethra. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human WNT9A (Wnt family member 9A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 59197675 | 59224378 | Mouse | 143 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319984 | Wnt9b | wingless-type MMTV integration site family, member 9B | Enables co-receptor binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and kidney development. Predicted to be located in extracellular region. Predicted to be part of Wnt-Frizzled-L RP5/6 complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; epithelium; genitourinary system; heart; and surface ectoderm. Orthologous to human WNT9B (Wnt family member 9B). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 103618188 | 103666098 | Mouse | 140 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1551747 | H2az2 | H2A.Z histone variant 2 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015] | 11 | 6377226 | 6394511 | Mouse | 1602 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 730924 | E2f1 | E2F transcription factor 1 | Enables DNA-binding transcription activator activity and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including anoikis; lens fiber cell apoptotic process; and quinolinate biosynthetic process. Located in chromatin and cytoplasm. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 154401320 | 154411812 | Mouse | 906 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619149 | Rhou | ras homolog family member U | Enables GTPase activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; Rac protein signal transduction; and regulation of cell shape. Predicted to be located in several cellular components, including Golgi membrane; focal adhesion; and podosome. Predi cted to be active in plasma membrane. Is expressed in several structures, including branchial pouch; cerebral cortex; ganglia; gut; and hair follicle. Orthologous to human RHOU (ras homolog family member U). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 124380609 | 124390622 | Mouse | 173 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 69487 | CCN4 | cellular communication network factor 4 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated sig naling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] | 8 | 133191039 | 133231690 | Human | 155 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 69431 | Ccn4 | cellular communication network factor 4 | INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; ASSOCIATED WITH Airway Remodeling; Experimental Liver Cirrhosis; Hyperoxia; FOUND IN cytoplasm (or tholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 7 | 100534578 | 100566287 | Rat | 155 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69488 | Ccn4 | cellular communication network factor 4 | Predicted to enable heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of cell differentiation; osteoblast differentiation; and osteoclast differentiation. Located in cytoplasm. Is expressed in several structures, including central ne rvous system; embryo mesenchyme; genitourinary system; limb; and skeleton. Orthologous to human CCN4 (cellular communication network factor 4). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 66763337 | 66795050 | Mouse | 164 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8860233 | Ccn4 | cellular communication network factor 4 | INVOLVED IN bone development (ortholog); glucose homeostasis (ortholog); negative regulation of chondrocyte differentiation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ort holog) | NW_004955461 | 7748399 | 7780359 | Chinchilla | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11849645 | CCN4 | cellular communication network factor 4 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell pr oliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | 8 | 129842580 | 129884528 | Bonobo | 39 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12426237 | CCN4 | cellular communication network factor 4 | INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell proliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | 13 | 29648720 | 29683822 | Dog | 39 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12733391 | Ccn4 | cellular communication network factor 4 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell pr oliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | NW_004936470 | 16110492 | 16134065 | Squirrel | 39 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14168890 | CCN4 | cellular communication network factor 4 | INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell proliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Pig | 39 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18446469 | CCN4 | cellular communication network factor 4 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell pr oliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | | | | Green Monkey | 39 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18903070 | Ccn4 | cellular communication network factor 4 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN bone development (ortholog); glucose homeostasis (ortholog); negative regulation of chondrocyte differentiation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 38 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625855935 | Ccn4 | cellular communication network factor 4 | INVOLVED IN bone development (ortholog); glucose homeostasis (ortholog); negative regulation of chondrocyte differentiation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); Experimental Liver Cirrhosis (ortholog); Hyperoxia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ort holog) | | | | Black Rat | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 621867 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits integrin binding; INVOLVED IN negative regulation of cell population proliferation; regulation of cell growth (ortholog); FOUND IN cell surface; nucleus; podosome; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 172910670 | 172922064 | Rat | 174 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 737121 | Ccn5 | cellular communication network factor 5 | Predicted to enable growth factor activity; heparin binding activity; and integrin binding activity. Acts upstream of or within regulation of cell growth. Located in extracellular space; nucleus; and plasma membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; long bone epiphyseal plate; and respiratory system. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 163662724 | 163675066 | Mouse | 177 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1351496 | CCN5 | cellular communication network factor 5 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated sig naling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] | 20 | 44714861 | 44727811 | Human | 168 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 9020099 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); nucleus (ortholog) | NW_004955445 | 12623333 | 12640127 | Chinchilla | 13 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11766671 | CCN5 | cellular communication network factor 5 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | 20 | 41045205 | 41058137 | Bonobo | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12219142 | CCN5 | cellular communication network factor 5 | INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | 24 | 32161703 | 32174573 | Dog | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12626148 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | NW_004936514 | 7997802 | 8010378 | Squirrel | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14159068 | CCN5 | cellular communication network factor 5 | INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | | | | Pig | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18609816 | CCN5 | cellular communication network factor 5 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | | | | Green Monkey | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18904758 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); podosome (ortholog) | | | | Naked Mole-Rat | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626080838 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN negative regulation of cell population proliferation (ortholog); regulation of cell growth (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); nucleus (ortholog) | | | | Black Rat | 13 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1345324 | CCN6 | cellular communication network factor 6 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated sig naling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 6 | 112052813 | 112069686 | Human | 187 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1564120 | Ccn6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); regulation of mitochondrial membrane potential (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast me taplastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN extracellular space (ortholog); mitochondrion (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; amphetamine | 20 | 44123932 | 44139745 | Rat | 49 | old_gene_name | gene, protein-coding, INFERRED [RefSeq] |
| 1622848 | Ccn6 | cellular communication network factor 6 | Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in extracellular matrix and extracellular space. Is expressed in embryo. Used to study breast metaplastic carcinoma and progressive pseudorheumatoid arthropathy of childhood. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 39026966 | 39049484 | Mouse | 81 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8980676 | Ccn6 | cellular communication network factor 6 | INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); regulation of mitochondrial membrane potential (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast metaplastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FO UND IN extracellular space (ortholog); mitochondrion (ortholog) | NW_004955526 | 4501331 | 4525866 | Chinchilla | 12 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11695241 | CCN6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast meta plastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred) | 6 | 109863877 | 109880480 | Bonobo | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12252250 | CCN6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast metaplastic carcinoma (ortholog); Desbuquois dysplasia (ortho log); FOUND IN extracellular region (inferred); extracellular space (inferred); mitochondrion (inferred) | 12 | 68488846 | 68499104 | Dog | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12537970 | Ccn6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast meta plastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936679 | 751664 | 767126 | Squirrel | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14023793 | CCN6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast metaplastic carcinoma (ortholog); Desbuquois dysplasia (ortho log); FOUND IN extracellular region (inferred); extracellular space (inferred); mitochondrion (inferred) | | | | Pig | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18430412 | CCN6 | cellular communication network factor 6 | ENCODES a protein that exhibits growth factor activity (inferred); heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast meta plastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18928482 | Ccn6 | cellular communication network factor 6 | ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); regulation of mitochondrial membrane potential (ortholog); ASSOCIATED WITH arthropathy (ortholog); breast metaplastic carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Naked Mole-Rat | 20 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14389764 | Wnt10 | | | | | | Fly | | symbol | gene, null |
| 621463 | Wnt11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (ortholog); INVOLVED IN cell differentiation; response to nutrient levels; adrenal gland development (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WI TH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride | 1 | 162545660 | 162565456 | Rat | 201 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1344477 | WNT11 | Wnt family member 11 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008] | 11 | 76186325 | 76210761 | Human | 236 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551956 | Wnt11 | wingless-type MMTV integration site family, member 11 | Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in heart development. Acts upstream of or within several processes, including Wnt signaling pathway; circulatory system development; and negative regulation of cell population proliferation. Located in ex tracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 98484293 | 98503954 | Mouse | 221 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9064812 | Wnt11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (ortholog); INVOLVED IN adrenal gland development (ortholog); artery morphogenesis (ortholog); atrial septum development (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pa thway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog) | NW_004955414 | 15674478 | 15694758 | Chinchilla | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11818010 | WNT11 | Wnt family member 11 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein kinase activator activity (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signali ng pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | 11 | 71239781 | 71263915 | Bonobo | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12104415 | WNT11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (inferred); signaling receptor binding (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | 21 | 22442496 | 22463040 | Dog | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12591524 | Wnt11 | Wnt family member 11 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein kinase activator activity (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signali ng pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | NW_004936498 | 4909041 | 4927482 | Squirrel | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14243631 | WNT11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (inferred); signaling receptor binding (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | | | | Pig | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18561180 | WNT11 | Wnt family member 11 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein kinase activator activity (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signali ng pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | | | | Green Monkey | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924878 | Wnt11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (ortholog); INVOLVED IN adrenal gland development (ortholog); artery morphogenesis (ortholog); atrial septum development (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pa thway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog) | | | | Naked Mole-Rat | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259621 | wnt11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625854772 | Wnt11 | Wnt family member 11 | ENCODES a protein that exhibits protein kinase activator activity (ortholog); INVOLVED IN adrenal gland development (ortholog); artery morphogenesis (ortholog); atrial septum development (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pa thway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); BCARD syndrome (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog) | | | | Black Rat | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1345805 | WNT16 | Wnt family member 16 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008] | 7 | 121325367 | 121341104 | Human | 72 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558269 | Wnt16 | wingless-type MMTV integration site family, member 16 | Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within bone remodeling and cardiac epithelial to mesenchymal transition. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including aliment ary system; brain; embryo mesenchyme; genitourinary system; and heart. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 22288179 | 22298521 | Mouse | 99 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562253 | Wnt16 | Wnt family member 16 | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcino ma pathway; FOUND IN cytoplasm (ortholog); extracellular space (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole | 4 | 51786728 | 51797137 | Rat | 81 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9019824 | Wnt16 | Wnt family member 16 | INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (ortholog); extracellular space (ortholog) | NW_004955479 | 3065312 | 3077260 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11864321 | WNT16 | Wnt family member 16 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | 7 | 113338322 | 113354002 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12219944 | WNT16 | Wnt family member 16 | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (inferred); extracellular region (inferr ed); extracellular space (inferred) | 14 | 59388034 | 59404812 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12579581 | Wnt16 | Wnt family member 16 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936605 | 3855640 | 3867166 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14054728 | WNT16 | Wnt family member 16 | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (inferred); extracellular region (inferr ed); extracellular space (inferred) | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18770634 | WNT16 | Wnt family member 16 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922760 | Wnt16 | Wnt family member 16 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pa thway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238011 | wnt16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626154792 | Wnt16 | Wnt family member 16 | INVOLVED IN bone remodeling (ortholog); cardiac epithelial to mesenchymal transition (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; FOUND IN cytoplasm (ortholog); extracellular space (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307015 | Wnt10a | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); epidermis morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical p athway; basal cell carcinoma pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol | 9 | 83798594 | 83811060 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315958 | WNT10A | Wnt family member 10A | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008] | 2 | 218874116 | 218893928 | Human | 381 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315959 | Wnt10a | wingless-type MMTV integration site family, member 10A | Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within neural crest cell differentiation; positive regulation of gene expression; and regulation of odontogenesis of dentin-containing tooth. Predicted to be located in extracellular region. Predicted to be acti ve in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 74831178 | 74843335 | Mouse | 178 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8776082 | Wnt10a | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); epidermis morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical p athway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog) | NW_004955453 | 14528373 | 14540801 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11739254 | WNT10A | Wnt family member 10A | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholo g); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 2B | 106140859 | 106154301 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12363405 | WNT10A | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (inferred); signaling receptor binding (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred) | 37 | 25463064 | 25475407 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12442614 | Wnt10a | Wnt family member 10A | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholo g); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | NW_004936569 | 1309140 | 1321923 | Squirrel | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14085908 | WNT10A | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (inferred); signaling receptor binding (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18731860 | WNT10A | Wnt family member 10A | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholo g); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920857 | Wnt10a | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); epidermis morphogenesis (ortholog); hair follicle development (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway ; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284786258 | wnt10a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626050942 | Wnt10a | Wnt family member 10A | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); epidermis morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical p athway; ASSOCIATED WITH Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); ectodermal dysplasia (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1304988 | Wnt10b | Wnt family member 10B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN cellular response to hydrostatic pressure; bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 17beta-estradiol 3-benzoate; 3,7-dihydropurine-6-thione; 5-azacytidine | 7 | 131801046 | 131806850 | Rat | 177 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312744 | WNT10B | Wnt family member 10B | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] | 12 | 48965340 | 48971735 | Human | 284 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8971678 | Wnt10b | Wnt family member 10B | INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (o rtholog) | NW_004955500 | 7782782 | 7800281 | Chinchilla | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12046529 | WNT10B | Wnt family member 10B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 12 | 39771163 | 39785411 | Bonobo | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12232331 | WNT10B | Wnt family member 10B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Ne oplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred) | 27 | 5599905 | 5605506 | Dog | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12727577 | Wnt10b | Wnt family member 10B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | NW_004936512 | 6768240 | 6774172 | Squirrel | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13973357 | WNT10B | Wnt family member 10B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Ne oplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 73 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18535993 | WNT10B | Wnt family member 10B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907931 | Wnt10b | Wnt family member 10B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249409 | wnt10b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626134427 | Wnt10b | Wnt family member 10B | INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Desbuquois dysplasia (ortholog); genetic disease (o rtholog) | | | | Black Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329329086 | wnt11b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155241315 | wnt11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255223 | wnt11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252905 | wnt16.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238012 | wnt16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284025127 | wnt10a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284180543 | wnt10a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231971 | wnt10b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252292 | wnt10b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 329329087 | wnt11b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 733303 | WNT2B | Wnt family member 2B | This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] | 1 | 112466541 | 112530165 | Human | 152 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312797 | WNT9A | Wnt family member 9A | The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008] | 1 | 227918656 | 227947932 | Human | 132 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319983 | WNT9B | Wnt family member 9B | The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 17 | 46833189 | 46886738 | Human | 121 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318289 | NKD1 | NKD inhibitor of Wnt signaling pathway 1 | In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003] | 16 | 50548396 | 50649249 | Human | 148 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1347334 | RHOU | ras homolog family member U | This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskelet al organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011] | 1 | 228644647 | 228746669 | Human | 164 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312067 | WNT6 | Wnt family member 6 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008] | 2 | 218859805 | 218874233 | Human | 189 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 30308771 | WNT3 | Wnt family member 3 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008] | 17 | 46762506 | 46818692 | Human | 277 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1317606 | WNT3A | Wnt family member 3A | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008] | 1 | 228006998 | 228061271 | Human | 294 | description | gene, protein-coding, REVIEWED [RefSeq] |
