CCN6 (cellular communication network factor 6) - Rat Genome Database

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Gene: CCN6 (cellular communication network factor 6) Canis lupus familiaris
Analyze
Symbol: CCN6
Name: cellular communication network factor 6
RGD ID: 12252250
Description: INVOLVED IN negative regulation of angiogenesis (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH arthropathy (ortholog); autosomal recessive spondyloepiphyseal dysplasia tarda (ortholog); breast metaplastic carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WISP3; WNT1 inducible signaling pathway protein 3; WNT1-inducible-signaling pathway protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,488,846 - 68,499,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,478,905 - 68,498,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1268,299,647 - 68,317,878 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01269,362,873 - 69,381,112 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1269,361,014 - 69,380,055 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,722,395 - 68,740,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,560,032 - 68,578,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,886,687 - 68,905,127 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,488,846 - 68,499,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,478,905 - 68,498,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1268,299,647 - 68,317,878 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01269,362,873 - 69,381,112 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1269,361,014 - 69,380,055 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,722,395 - 68,740,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,560,032 - 68,578,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,886,687 - 68,905,127 (+)NCBIUU_Cfam_GSD_1.0
CCN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386112,052,813 - 112,069,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6112,054,075 - 112,069,686 (+)EnsemblGRCh38hg38GRCh38
GRCh376112,375,307 - 112,390,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,481,971 - 112,497,582 (+)NCBINCBI36Build 36hg18NCBI36
Build 346112,482,063 - 112,497,578NCBI
Celera6113,116,562 - 113,132,191 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,950,089 - 109,965,718 (+)NCBIHuRef
CHM1_16112,637,620 - 112,653,229 (+)NCBICHM1_1
T2T-CHM13v2.06113,236,232 - 113,253,104 (+)NCBIT2T-CHM13v2.0
Ccn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,026,966 - 39,049,484 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,026,966 - 39,039,790 (-)EnsemblGRCm39 Ensembl
GRCm381039,150,970 - 39,174,376 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,150,970 - 39,163,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv371038,870,777 - 38,883,600 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361038,930,930 - 38,943,587 (-)NCBIMGSCv36mm8
Celera1040,035,173 - 40,048,005 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.19NCBI
Ccn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,123,932 - 44,139,745 (-)NCBIGRCr8
mRatBN7.22042,569,309 - 42,585,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,569,309 - 42,585,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,318,205 - 44,334,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02043,977,415 - 43,993,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,710,380 - 44,726,274 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,237,491 - 44,255,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,237,491 - 44,255,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02045,964,515 - 45,980,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,297,076 - 43,312,790 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2043,285,682 - 43,301,319 (-)NCBICelera
Cytogenetic Map20q12NCBI
Ccn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555264,502,654 - 4,522,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555264,501,331 - 4,525,866 (-)NCBIChiLan1.0ChiLan1.0
CCN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25132,059,715 - 132,086,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,947,929 - 129,973,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,863,877 - 109,880,480 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,939,882 - 113,955,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,939,975 - 113,955,427 (+)Ensemblpanpan1.1panPan2
Ccn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,519,416 - 103,534,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679750,934 - 769,242 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679751,664 - 767,126 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl178,005,847 - 78,019,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1178,005,442 - 78,020,595 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,626,572 - 87,687,187 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11361,786,246 - 61,806,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1361,786,312 - 61,803,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,121,867 - 34,138,513 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462500748,593 - 50,771 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCN6
228 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006416   ⟹   ENSCAFP00000005940
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1268,478,905 - 68,498,049 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000049461   ⟹   ENSCAFP00000040633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1268,479,198 - 68,498,049 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032327   ⟹   ENSCAFP00845025269
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1269,361,014 - 69,380,055 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032381   ⟹   ENSCAFP00845025313
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1269,362,626 - 69,380,055 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032432   ⟹   ENSCAFP00845025357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1269,362,626 - 69,380,055 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032471   ⟹   ENSCAFP00845025389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1269,362,626 - 69,380,055 (+)Ensembl
RefSeq Acc Id: XM_038492808   ⟹   XP_038348736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11268,722,395 - 68,740,609 (+)NCBI
RefSeq Acc Id: XM_038555060   ⟹   XP_038410988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01268,886,687 - 68,905,127 (+)NCBI
RefSeq Acc Id: XM_038618929   ⟹   XP_038474857
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01268,560,032 - 68,578,123 (+)NCBI
RefSeq Acc Id: XM_038684494   ⟹   XP_038540422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01269,362,873 - 69,381,112 (+)NCBI
RefSeq Acc Id: XM_038686355   ⟹   XP_038542283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1268,299,647 - 68,317,878 (+)NCBI
Ensembl Acc Id: ENSCAFP00000040633   ⟸   ENSCAFT00000049461
Ensembl Acc Id: ENSCAFP00000005940   ⟸   ENSCAFT00000006416
RefSeq Acc Id: XP_038348736   ⟸   XM_038492808
RefSeq Acc Id: XP_038474857   ⟸   XM_038618929
RefSeq Acc Id: XP_038540422   ⟸   XM_038684494
- UniProtKB: A0A8I3NZY6 (UniProtKB/TrEMBL),   A0A8P0NRR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038542283   ⟸   XM_038686355
- UniProtKB: A0A8I3NZY6 (UniProtKB/TrEMBL),   A0A8P0NRR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410988   ⟸   XM_038555060
- UniProtKB: A0A8I3NZY6 (UniProtKB/TrEMBL),   A0A8P0NRR5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845025357   ⟸   ENSCAFT00845032432
Ensembl Acc Id: ENSCAFP00845025269   ⟸   ENSCAFT00845032327
Ensembl Acc Id: ENSCAFP00845025389   ⟸   ENSCAFT00845032471
Ensembl Acc Id: ENSCAFP00845025313   ⟸   ENSCAFT00845032381
Protein Domains
CTCK   IGFBP N-terminal

Promoters
RGD ID:13685536
Promoter ID:EPDNEW_C3605
Type:single initiation site
Name:WISP3_1
Description:WNT1 inducible signaling pathway protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11268,488,842 - 68,488,902EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004005 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845018276 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006416.5 UniProtKB/TrEMBL
  ENSCAFT00000049461.4 UniProtKB/TrEMBL
  ENSCAFT00000108977.1 UniProtKB/TrEMBL
  ENSCAFT00845032327.1 UniProtKB/TrEMBL
  ENSCAFT00845032381 ENTREZGENE
  ENSCAFT00845032381.1 UniProtKB/TrEMBL
  ENSCAFT00845032432.1 UniProtKB/TrEMBL
  ENSCAFT00845032471.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro CCN UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  IGFBP-like UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene WISP3 ENTREZGENE
PANTHER CELLULAR COMMUNICATION NETWORK FACTOR 6 UniProtKB/TrEMBL
  CONNECTIVE TISSUE GROWTH FACTOR-RELATED UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
  IGFBP UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/TrEMBL
PIRSF IGFBP_rP_CNN UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
  IGFBP_N_1 UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00121 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A8I3NZY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P5V4_CANLF UniProtKB/TrEMBL
  A0A8I3PB25_CANLF UniProtKB/TrEMBL
  A0A8I3PD27_CANLF UniProtKB/TrEMBL
  A0A8P0N6U0_CANLF UniProtKB/TrEMBL
  A0A8P0NRR5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TMR2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48416 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-23 CCN6  cellular communication network factor 6  WISP3  WNT1 inducible signaling pathway protein 3  Symbol and/or name change 5135510 APPROVED