WNT10A (Wnt family member 10A) - Rat Genome Database

Name: WNT10A
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: WNT10A (Wnt family member 10A) Chlorocebus sabaeus

Analyze

Symbol:

WNT10A

Name:

Wnt family member 10A

RGD ID:

18731860

Description:

ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN neural crest cell differentiation (ortholog); positive regulation of gene expression (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); Arthralgia (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein Wnt-10a

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,781,705 - 104,795,500 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,782,191 - 104,794,854 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	94,605,980 - 94,620,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alacrima, achalasia, and impaired intellectual development syndrome (ISO)

Arthralgia (ISO)

bladder exstrophy-epispadias-cloacal exstrophy complex (ISO)

cerebrotendinous xanthomatosis (ISO)

ectodermal dysplasia (ISO)

genetic disease (ISO)

hypohidrotic ectodermal dysplasia (ISO)

mantle cell lymphoma (ISO)

myofibrillar myopathy 1 (ISO)

Neurodevelopmental Disorders (ISO)

Odontoonychodermal Dysplasia (ISO)

palmoplantar keratosis (ISO)

paroxysmal nonkinesigenic dyskinesia 1 (ISO)

Schopf-Schulz-Passarge syndrome (ISO)

Selective Tooth Agenesis 2 (ISO)

Selective Tooth Agenesis 4 (ISO)

tooth agenesis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IEA)

cell fate commitment (IEA)

cellular response to transforming growth factor beta stimulus (IEA)

epidermis morphogenesis (IEA)

hair follicle development (IEA)

hair follicle morphogenesis (IEA)

neural crest cell differentiation (IEA,ISO)

neuron differentiation (IEA)

odontogenesis (IEA)

positive regulation of gene expression (IEA,ISO)

regulation of odontogenesis of dentin-containing tooth (IEA,ISO)

sebaceous gland development (IEA)

skin development (IEA)

tongue development (IEA)

Wnt signaling pathway (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

cytokine activity (IEA)

frizzled binding (IEA)

receptor ligand activity (IEA)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

WNT10A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,781,705 - 104,795,500 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,782,191 - 104,794,854 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	94,605,980 - 94,620,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

WNT10A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,874,116 - 218,893,928 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,880,852 - 218,899,581 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	219,745,574 - 219,758,650 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	219,453,499 - 219,466,895 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	219,570,759 - 219,584,156	NCBI
Celera	2	213,515,015 - 213,528,391 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	211,599,762 - 211,613,219 (+)	NCBI		HuRef
CHM1_1	2	219,752,633 - 219,766,029 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	219,362,519 - 219,382,296 (+)	NCBI		T2T-CHM13v2.0

Wnt10a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,831,178 - 74,843,335 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,830,675 - 74,843,338 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	74,792,019 - 74,804,176 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,791,516 - 74,804,179 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	74,838,593 - 74,850,750 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,724,723 - 74,737,383 (+)	NCBI		MGSCv36	mm8
Celera	1	75,347,091 - 75,359,286 (+)	NCBI		Celera
Cytogenetic Map	1	C4	NCBI
cM Map	1	38.54	NCBI

Wnt10a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,798,594 - 83,811,060 (+)	NCBI		GRCr8
mRatBN7.2	9	76,349,931 - 76,362,400 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,349,931 - 76,362,400 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	84,795,104 - 84,807,594 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,924,044 - 89,936,533 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	88,310,219 - 88,322,718 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	82,053,581 - 82,066,047 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	82,053,581 - 82,066,047 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	81,816,108 - 81,829,217 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	74,124,403 - 74,137,508 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	74,271,590 - 74,284,435 (+)	NCBI
Celera	9	73,922,407 - 73,934,776 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

Wnt10a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	14,528,153 - 14,540,818 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	14,528,373 - 14,540,801 (-)	NCBI	ChiLan1.0	ChiLan1.0

WNT10A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	121,513,053 - 121,527,016 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	121,528,018 - 121,542,012 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	106,140,859 - 106,154,301 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	224,735,800 - 224,748,567 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	224,736,598 - 224,747,912 (+)	Ensembl	panpan1.1		panPan2

WNT10A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,463,064 - 25,475,407 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,462,748 - 25,474,764 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	26,283,474 - 26,295,608 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,478,692 - 25,490,806 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,478,251 - 25,538,779 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	25,383,325 - 25,395,473 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	25,318,096 - 25,330,240 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	25,339,120 - 25,351,266 (+)	NCBI		UU_Cfam_GSD_1.0

Wnt10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	174,966,359 - 174,979,148 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	1,309,106 - 1,321,931 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	1,309,140 - 1,321,923 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WNT10A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,925,499 - 120,938,430 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	120,925,204 - 120,939,032 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	134,032,841 - 134,033,943 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Wnt10a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	6,128,256 - 6,140,235 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624823	6,126,238 - 6,140,764 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	19	18	36
Below cutoff	6	2	10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007966316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000006657 ⟹ ENSCSAP00000004859

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	10	104,782,191 - 104,794,854 (+)	Ensembl

RefSeq Acc Id:

XM_007966316 ⟹ XP_007964507

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	10	104,781,705 - 104,795,500 (+)	NCBI
Vero_WHO_p1.0	NW_023666040	94,605,980 - 94,620,038 (-)	NCBI

Sequence:

show sequence

GCGGCAGAGCTCCCCGAGCCGGGACAGTCACTTACTCTCCAGGCAGTGGGGCCCGACACAGACA
GCGCCGCCCCTGCCAGCCCGCCTCGCACGCCCTCGGAAGCACAGGCTCCCGGCGCTGCGCTGGA
GGGCTCCCCGGCACCCCAGCCTCCCGTCCCCAGCCCGCTGCACCTCCAGGCCCCCCTTACCCTT
GAGAGGCACCGGGAGTTGTCGCGGGGGGGCCTCGGGAAATTCCCCGGACCCCTGTGCCAGGAGG
TGCCCGGTTCGCCCGCTCTTCACCCCCCGCCCCCCCCGAGGGCGGTGCCCGGGGGTGCTGCCCC
ATGGAGCGGGGAGGCGGGCGCCGTCTGCTCCGGGAGCCCTGACCCGAGTCGGAGTTGTGTGTCG
CAGCCGCCCCGACCCCCCGCCGATCATGCGCCGGCGCCCCTGGCTCTCCAGTCCCACCGGGCTG
TGAGCCCCCCATTCCCAGCCCGTCAGGGCCTGCGCGCCATGGGCAGCGCCCACCCTCGCCCCTG
GCTTCGGCTCCGACCCCAGCCCCAGCCGCGGCCAGCGCTCTGGGTGCTCCTGTTCTTCCTACTG
CTGCTGGCTGCTGCCATGCCCAGGTCAGCACCCAATGACATTCTGGACCTCCGCCTCCCCCCGG
AGCCTGTGCTCAATGCCAACACAGTGTGCCTAACATTGCCAGGCCTGAGCCGGCGGCAGATGGA
GGTGTGTGTGCGTCACCCTGATGTGGCTGCCTCAGCCATACAGGGCATCCAGATCGCTATCCAC
GAATGCCAACACCAATTCAGGGACCAGCGCTGGAACTGCTCAAGCCTGGAGACTCGCAACAAGA
TCCCCTATGAAAGTCCCATCTTCAGCAGAGGTTTCCGAGAGAGCGCTTTTGCCTACGCCATCGC
GGCAGCTGGTGTTGTACATGCCGTGTCCAATGCGTGTGCCCTGGGCAAACTAAAGGCCTGTGGC
TGCGACGCGTCCCGGCGAGGGGATGAGGAGGCCTTCCGTAGGAAGCTGCACCGCCTACAACTGG
ACGCACTGCAGCGTGGTAAGGGCCTGAGCCATGGGGTCCCGGAACACCCAGCCCTGCCCACAGC
CAGCCCAGGCCTGCAGGACTCCTGGGAGTGGGGCGGCTGCAGCCCCGACATGGGCTTCGGGGAG
CGCTTCTCTAAGGACTTTCTGGACTCCCGGGAGCCTCACAGAGACATCCACGCAAGAATGAGGC
TTCACAACAACCGAGTTGGGAGGCAGGCAGTGATGGAGAACATGCGGCGGAAGTGCAAGTGCCA
CGGCACGTCAGGCAGCTGCCAGCTCAAGACGTGCTGGCAGGTGACGCCCGAGTTCCGCACCGTG
GGGGCGCTGCTGCGCAGCCGCTTCCACCGCGCCACGCTCATCCGGCCACACAACCGCAACGGCG
GCCAGCTGGAGCCGGGCCCAGCGGGGGTACCCTCGCCGGCTCCCGGCGCTCCCGGGCCGCGCCG
CCGGGCCAGCCCCGCCGACCTGGTCTACTTCGAAAAGTCACCCGACTTCTGCGAGCGCGAGCCG
CGCTTGGACTCGGCGGGCACCGTGGGCCGCCTGTGCAACAAGAGCAGCGCGGGCTCGGATGGCT
GCGGCAGCATGTGCTGCGGCCGCGGCCACAACATCCTGCGCCAGACGCGCAGCGAGCGCTGCCA
CTGCCGCTTCCACTGGTGCTGCTTCGTGGTCTGCGAAGAGTGCCGCATCACCGAGTGGGTCAGC
GTCTGCAAGTGAGCGGCCCGGGGTCCCCTGGGTCCTGAACGAAGTCCCCTCCTGGAGCCTGGCC
CTCTGAGGCTTACGGCCTTGGCAAGGCAGCATAGCCTTGGCTCTTGGGAGAGGAGATTGGACCA
CATGATCTTACAGGAACCTCTCAGCTCTGAGGTCTGTGATCGCTGGACAGTCCAGGCCTGTCTG
AACCCCACCACTCACTTCTGTGGGCTCTAGGACTTACTGGGTTCTTCCTGCCTCCCCCAAGCCC
AGACAGTTCAGTTGGGCTGGGGTTTGCCCCATACACTAAAACAAGCGTCAGCCAGGCAACCCCT
CAGTCTGTCTCCATCCTTTCACCCCTTCCCTGGAGATGGGAGGTAGGGAATGAATAGAAGCTGA
TGGGCAGAGAGAGGAGGATTAAAAAAAAGAAATAGACATAACTGAGCTGAAGTAATTCCATAAA
CGACCCAGACACCCTCCCCCACCATTCCCCTCATCATTCATTTAACAAATATTTATTTTGCACT
CTCTTTGCGGCACTCTGGGGGGCGTGGGGGTGGCAGTGTGAGGCACTGGGGCCACAGACGTAAG
TCAGACACAGCACTTGTCCTCTTGGAGGTTACATTCTTGCTGGGGGGAGGCATGGGCAATAAAC
AAGTAAATATACAAACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007964507	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004859
	ENSCSAP00000004859.1

RefSeq Acc Id:	XP_007964507 ⟸ XM_007966316
- UniProtKB:	A0A0D9R8C0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000004859 ⟸ ENSCSAT00000006657

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008612	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006657.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2460.20	UniProtKB/TrEMBL
InterPro	Wnt	UniProtKB/TrEMBL
	Wnt10	UniProtKB/TrEMBL
	Wnt_C	UniProtKB/TrEMBL
	Wnt_CS	UniProtKB/TrEMBL
KEGG Report	csab:103217886	UniProtKB/TrEMBL
NCBI Gene	WNT10A	ENTREZGENE
PANTHER	PROTEIN WNT-10A	UniProtKB/TrEMBL
	PTHR12027	UniProtKB/TrEMBL
Pfam	wnt	UniProtKB/TrEMBL
PRINTS	WNT10PROTEIN	UniProtKB/TrEMBL
	WNTPROTEIN	UniProtKB/TrEMBL
PROSITE	WNT1	UniProtKB/TrEMBL
SMART	WNT1	UniProtKB/TrEMBL
UniProt	A0A0D9R8C0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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