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ONTOLOGY REPORT - ANNOTATIONS

Term:scaffold protein binding
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Accession:GO:0097110 term browser browse the term
Definition:Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.


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scaffold protein binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY5 adenylate cyclase 5 enables IEA Ensembl GO_REF:0000107 NCBI chr13:136,965,746...137,133,795
Ensembl chr13:136,972,801...137,135,347 		JBrowse link
G ADCY6 adenylate cyclase 6 enables ISO (PMID:20164376) MGI PMID:20164376 NCBI chr 5:14,834,420...14,855,309
Ensembl chr 5:14,834,426...14,850,728 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:88,538,938...88,544,330
Ensembl chr 7:88,538,984...88,547,392 		JBrowse link
G ATG4B autophagy related 4B cysteine peptidase enables IEA Ensembl GO_REF:0000107 NCBI chr15:140,223,903...140,245,590
Ensembl chr15:140,223,904...140,246,321 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 enables ISO (MGI:5499724|PMID:18591664) BHF-UCL PMID:18591664 MGI:5499724 NCBI chr 9:64,336,354...64,445,669
Ensembl chr 9:64,336,499...64,445,663 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:12421375 PMID:15673667 PMID:15758177 RGD:11576289 RGD:9684984 RGD:9684988 NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase enables IEA Ensembl GO_REF:0000107 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G enables IEA Ensembl GO_REF:0000107 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H enables IEA Ensembl GO_REF:0000107 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177 		JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO RGD PMID:19416975 RGD:5491011 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CASP8 caspase 8 enables IEA Ensembl GO_REF:0000107 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CAV2 caveolin 2 enables ISO (MGI:5613482|PMID:12091389) BHF-UCL PMID:12091389 MGI:5613482 NCBI chr18:29,699,012...29,707,277
Ensembl chr18:29,699,020...29,707,277 		JBrowse link
G CD163 CD163 molecule enables IEA Ensembl GO_REF:0000107 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498 		JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone enables IEA Ensembl GO_REF:0000107 NCBI chr 2:69,202,695...69,212,909
Ensembl chr 2:69,201,579...69,225,994 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:22593058 RGD:7205692 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex enables IEA Ensembl GO_REF:0000107 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G CIT citron rho-interacting serine/threonine kinase enables IEA
ISO		 Ensembl
RGD		 PMID:9870942 GO_REF:0000107 RGD:70684 NCBI chr14:33,009,828...33,195,985
Ensembl chr14:33,009,877...33,196,286 		JBrowse link
G CRIPT CXXC repeat containing interactor of PDZ3 domain enables ISO (PMID:17474715) BHF-UCL PMID:17474715 NCBI chr 3:93,911,425...93,925,916 JBrowse link
G CRK CRK proto-oncogene, adaptor protein ISO RGD PMID:20623582 RGD:11568073 NCBI chr12:47,656,805...47,685,641
Ensembl chr12:47,657,865...47,685,908 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 enables IEA Ensembl GO_REF:0000107 NCBI chr12:52,550,138...52,574,021
Ensembl chr12:52,550,141...52,575,143 		JBrowse link
G DLGAP3 DLG associated protein 3 enables ISO PMID:10433269 BHF-UCL PMID:10433269 RGD:8554380 NCBI chr 6:91,120,406...91,184,146
Ensembl chr 6:91,120,412...91,160,214 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:198,815...211,346
Ensembl chr 1:199,358...211,346 		JBrowse link
G DSP desmoplakin enables IEA Ensembl GO_REF:0000107 NCBI chr 7:4,862,649...4,915,626
Ensembl chr 7:4,862,649...4,915,623 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO RGD PMID:12097491 RGD:628355 NCBI chr14:40,455,954...40,458,352
Ensembl chr14:40,455,985...40,459,104 		JBrowse link
G DYNLL2 dynein light chain LC8-type 2 ISO RGD PMID:12097491 RGD:628355 NCBI chr12:34,348,336...34,356,478
Ensembl chr12:34,349,294...34,356,472 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase enables ISO (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581 		JBrowse link
G GIT1 GIT ArfGAP 1 ISO RGD PMID:12629171 RGD:152995492 NCBI chr12:45,768,172...45,783,652
Ensembl chr12:45,768,176...45,783,658 		JBrowse link
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 enables ISO PMID:10939335 SynGO-UCL
RGD		 PMID:10939335 PMID:14597197 PMID:23460828 RGD:152975667 RGD:152995495 RGD:2313285 NCBI chr16:69,332,786...69,654,366
Ensembl chr16:69,332,587...69,655,380 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO RGD PMID:10414981 RGD:632958 NCBI chr 8:46,078,122...46,247,144
Ensembl chr 8:46,078,276...46,241,914 		JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:125,821,195...127,130,617
Ensembl chr 8:125,819,951...127,129,763 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO Dlg4 species unclear; MMO:0000683 RGD PMID:12597860 RGD:152995391 NCBI chr13:192,877,707...193,296,954
Ensembl chr13:192,877,606...193,294,952 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 ISO Dlg4 species unclear;MMO:0000683 RGD PMID:12597860 RGD:152995391 NCBI chr 1:68,052,086...68,680,448
Ensembl chr 1:68,057,538...68,679,256 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A enables ISO PMID:20847060 BHF-UCL
RGD		 PMID:20847060 PMID:22375001 RGD:401950481 RGD:8554370 NCBI chr 3:32,749,329...33,149,350
Ensembl chr 3:32,750,700...33,143,499 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:17270176 RGD:13432036 NCBI chr 5:58,477,862...58,948,735
Ensembl chr 5:58,480,528...58,927,558 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:28162981 RGD:13513989 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 enables ISO PMID:28392297 ARUK-UCL PMID:28392297 RGD:21201273 NCBI chr13:33,924,303...33,938,279
Ensembl chr13:33,926,804...33,938,269 		JBrowse link
G GRM3 glutamate metabotropic receptor 3 enables ISO PMID:28392297 ARUK-UCL PMID:28392297 RGD:21201273 NCBI chr 9:93,731,210...93,974,718
Ensembl chr 9:93,731,217...93,973,543 		JBrowse link
G HOMER1 homer scaffold protein 1 enables ISO PMID:10433269 BHF-UCL PMID:10433269 RGD:8554380 NCBI chr 2:88,116,664...88,253,843
Ensembl chr 2:88,122,882...88,255,281 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 enables IEA Ensembl GO_REF:0000107
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta enables IEA Ensembl GO_REF:0000107 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer enables IEA Ensembl GO_REF:0000107 NCBI chr16:35,101,304...35,151,832
Ensembl chr16:35,101,306...35,192,220 		JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:46,935,923...47,465,681
Ensembl chr 5:46,935,932...47,464,125 		JBrowse link
G KARS1 lysyl-tRNA synthetase 1 enables ISO (MGI:3055639|PMID:12060739) CAFA PMID:12060739 MGI:3055639 NCBI chr 6:12,057,475...12,073,749
Ensembl chr 6:12,056,571...12,073,748 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:65,439,336...65,442,207
Ensembl chr 5:65,439,336...65,442,207 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 enables IEA Ensembl GO_REF:0000107 NCBI chr18:6,242,826...6,279,154
Ensembl chr18:6,243,524...6,279,111 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:1,675,323...1,989,110
Ensembl chr 2:1,675,360...1,989,111 		JBrowse link
G KIF1B kinesin family member 1B ISO RGD PMID:12097473 RGD:8553481 NCBI chr 6:70,495,143...70,663,464
Ensembl chr 6:70,495,144...70,661,798 		JBrowse link
G KIF5A kinesin family member 5A ISO Disc1 RGD PMID:17202468 RGD:4107038 NCBI chr 5:22,813,617...22,851,976
Ensembl chr 5:22,816,854...22,851,973 		JBrowse link
G KRT15 keratin 15 enables IEA Ensembl GO_REF:0000107 NCBI chr12:21,124,605...21,130,247
Ensembl chr12:21,124,705...21,130,241 		JBrowse link
G KRT18 keratin 18 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429 		JBrowse link
G KRT5 keratin 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:17,862,047...17,868,397
Ensembl chr 5:17,862,051...17,868,402 		JBrowse link
G KRT8 keratin 8 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404 		JBrowse link
G LOC100522887 caspase-13 ISO RGD PMID:19416975 RGD:5491011 NCBI chr 9:35,167,567...35,185,791 JBrowse link
G LOC100624109 neuroligin-4, X-linked enables ISO (PMID:17292328)
(PMID:11368788)		 BHF-UCL PMID:11368788 PMID:17292328 NCBI chr  X:2,701,397...3,103,824
NCBI chr  Y:1,645,491...1,946,441 		JBrowse link
G LRP4 LDL receptor related protein 4 enables ISO PMID:16819975 UniProt PMID:16819975 RGD:8554698 NCBI chr 2:15,616,137...15,672,876
Ensembl chr 2:15,616,131...15,672,874 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase enables IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:74,626,739...74,651,352
Ensembl chr 2:74,626,783...74,651,348 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 enables ISO PMID:20455999 BHF-UCL PMID:20455999 RGD:10047313 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MYH9 myosin heavy chain 9 ISO RGD PMID:21598299 RGD:12798522 NCBI chr 5:11,365,603...11,456,475
Ensembl chr 5:11,360,660...11,456,472 		JBrowse link
G NCK2 NCK adaptor protein 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664 		JBrowse link
G NLGN1 neuroligin 1 enables ISO (PMID:17474715) BHF-UCL PMID:17474715 NCBI chr13:111,851,007...112,727,202
Ensembl chr13:112,035,854...112,725,618 		JBrowse link
G NLGN3 neuroligin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:57,174,506...57,204,770
Ensembl chr  X:57,176,103...57,201,461 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 ISO RGD PMID:19416975 RGD:5491011 NCBI chr12:51,479,968...51,495,540 JBrowse link
G NOS1 nitric oxide synthase 1 enables ISO PMID:18591664 BHF-UCL PMID:18591664 RGD:8554165 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944 		JBrowse link
G NOS3 nitric oxide synthase 3 enables ISO
IEA		 RGD
Ensembl		 PMID:12566108 PMID:15007069 GO_REF:0000107 RGD:1599542 RGD:7794688 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G P2RX7 purinergic receptor P2X 7 ISO RGD PMID:19416975 RGD:5491011 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G P2RY1 purinergic receptor P2Y1 enables ISO PMID:20847060 BHF-UCL PMID:20847060 RGD:8554370 NCBI chr13:92,991,150...92,997,702
Ensembl chr13:92,991,152...92,997,700 		JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:19416975 RGD:5491011 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PARK7 Parkinsonism associated deglycase enables IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PDE4D phosphodiesterase 4D enables IEA Ensembl GO_REF:0000107 NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,302...39,306,364 		JBrowse link
G PHF6 PHD finger protein 6 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:110,249,010...110,311,503
Ensembl chr  X:110,249,010...110,303,017 		JBrowse link
G PLCG2 phospholipase C gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G PSAP prosaposin enables IEA Ensembl GO_REF:0000107 NCBI chr14:74,734,185...74,820,645
Ensembl chr14:74,734,189...74,887,763 		JBrowse link
G RYR2 ryanodine receptor 2 enables ISO PMID:11590243 BHF-UCL PMID:11590243 RGD:1599255 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 enables IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 enables ISO PMID:10433269 BHF-UCL PMID:10433269 RGD:8554380 NCBI chr 6:55,452,095...55,496,304
Ensembl chr 6:55,451,094...55,499,031 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 enables ISO PMID:10433269
(MGI:3624607|PMID:16606358)		 BHF-UCL PMID:10433269 PMID:16606358 MGI:3624607 RGD:8554380 NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase enables IEA Ensembl GO_REF:0000107 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G SYK spleen associated tyrosine kinase enables IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TCOF1 treacle ribosome biogenesis factor 1 enables IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:151,368,264...151,401,029
Ensembl chr 2:151,368,289...151,401,027 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 enables ISO (PMID:11602640) BHF-UCL PMID:11602640 NCBI chr 7:36,510,253...36,531,796
Ensembl chr 7:36,510,253...36,531,796 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G UBTF upstream binding transcription factor enables IEA Ensembl GO_REF:0000107 NCBI chr12:18,989,833...19,006,145
Ensembl chr12:18,989,836...19,006,129 		JBrowse link
G VIM vimentin enables IEA Ensembl GO_REF:0000107 NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170 		JBrowse link
G XIAP X-linked inhibitor of apoptosis ISO RGD PMID:19416975 RGD:5491011 NCBI chr  X:101,399,374...101,440,021
Ensembl chr  X:101,399,812...101,440,013 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,495...6,929,052 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon enables IEA Ensembl GO_REF:0000107 NCBI chr12:47,601,133...47,645,327
Ensembl chr12:47,600,745...47,645,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18690
    binding 16249
      protein binding 14178
        scaffold protein binding 90
paths to the root