LRP4 (LDL receptor related protein 4) - Rat Genome Database

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Gene: LRP4 (LDL receptor related protein 4) Sus scrofa
Analyze
Symbol: LRP4
Name: LDL receptor related protein 4
RGD ID: 14281862
Description: ENCODES a protein that exhibits apolipoprotein binding (ortholog); scaffold protein binding (ortholog); INVOLVED IN dendrite morphogenesis (ortholog); dorsal/ventral pattern formation (ortholog); embryonic digit morphogenesis (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH Cenani-Lenz syndactyly syndrome (ortholog); congenital disorder of glycosylation type IIc (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); plasma membrane raft (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,979,254 - 17,017,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,979,254 - 17,017,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,856,717 - 46,918,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,856,717 - 46,918,642 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,878,268 - 46,940,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,834,994 - 46,896,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,834,994 - 46,874,397NCBI
Celera1147,024,050 - 47,085,802 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,584,196 - 46,645,441 (-)NCBIHuRef
CHM1_11146,876,690 - 46,938,585 (-)NCBICHM1_1
T2T-CHM13v2.01147,013,618 - 47,075,418 (-)NCBIT2T-CHM13v2.0
Lrp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,287,794 - 91,344,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,287,856 - 91,344,124 (+)EnsemblGRCm39 Ensembl
GRCm38291,457,456 - 91,513,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,297,688 - 91,354,058 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,258,540 - 91,314,618 (+)NCBIMGSCv36mm8
Celera292,845,990 - 92,902,350 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Lrp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
Lrp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,191,338 - 1,238,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,191,338 - 1,238,227 (+)NCBIChiLan1.0ChiLan1.0
LRP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,062,785 - 49,123,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,082,564 - 49,143,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,808,090 - 46,868,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,364,195 - 47,409,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,366,321 - 47,411,105 (-)Ensemblpanpan1.1panPan2
LRP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,616,683 - 42,667,297 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,616,426 - 42,665,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,344,660 - 41,396,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,271,285 - 43,323,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,271,155 - 43,323,246 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,756,909 - 42,808,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,312,112 - 42,364,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,041,646 - 43,093,851 (+)NCBIUU_Cfam_GSD_1.0
Lrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,100,527 - 20,153,707 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,211,514 - 2,263,937 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,211,519 - 2,262,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,393,489 - 18,474,514 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,413,513 - 18,471,444 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,697,194 - 115,757,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,708,866 - 1,757,629 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRP4
1505 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 5
Low 9 4 3 5 2 18 2 3 1
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014468   ⟹   ENSSSCP00000014076
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057167   ⟹   ENSSSCP00000042633
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)Ensembl
RefSeq Acc Id: XM_021085230   ⟹   XP_020940889
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020940889   ⟸   XM_021085230
- UniProtKB: A0A8D2CBH7 (UniProtKB/TrEMBL),   A0A480JH13 (UniProtKB/TrEMBL),   A0A8D0N9X6 (UniProtKB/TrEMBL),   A0A8D1T6G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014076   ⟸   ENSSSCT00000014468
RefSeq Acc Id: ENSSSCP00000042633   ⟸   ENSSSCT00000057167
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013248 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045838 UniProtKB/TrEMBL
  ENSSSCG00015029828 UniProtKB/TrEMBL
  ENSSSCG00025050237 UniProtKB/TrEMBL
  ENSSSCG00030017868 UniProtKB/TrEMBL
  ENSSSCG00035068302 UniProtKB/TrEMBL
  ENSSSCG00040075748 UniProtKB/TrEMBL
  ENSSSCG00045039496 UniProtKB/TrEMBL
  ENSSSCG00050016308 UniProtKB/TrEMBL
  ENSSSCG00055029647 UniProtKB/TrEMBL
  ENSSSCG00060023859 UniProtKB/TrEMBL
  ENSSSCG00065055413 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014468 ENTREZGENE
  ENSSSCT00000014468.4 UniProtKB/TrEMBL
  ENSSSCT00005074152.1 UniProtKB/TrEMBL
  ENSSSCT00015039618.1 UniProtKB/TrEMBL
  ENSSSCT00025068784.1 UniProtKB/TrEMBL
  ENSSSCT00030024696.1 UniProtKB/TrEMBL
  ENSSSCT00035092177.1 UniProtKB/TrEMBL
  ENSSSCT00040105221.1 UniProtKB/TrEMBL
  ENSSSCT00040105224.1 UniProtKB/TrEMBL
  ENSSSCT00045068818.1 UniProtKB/TrEMBL
  ENSSSCT00045068819.1 UniProtKB/TrEMBL
  ENSSSCT00050022222.1 UniProtKB/TrEMBL
  ENSSSCT00055058922.1 UniProtKB/TrEMBL
  ENSSSCT00055058949.1 UniProtKB/TrEMBL
  ENSSSCT00060032392.1 UniProtKB/TrEMBL
  ENSSSCT00065075895.1 UniProtKB/TrEMBL
  ENSSSCT00065075902.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene LRP4 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1 UniProtKB/TrEMBL
  MEGALIN, ISOFORM A UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A480JH13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0M7U1_PIG UniProtKB/TrEMBL
  A0A8D0N9X6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1G4T1_PIG UniProtKB/TrEMBL
  A0A8D1JLD3_PIG UniProtKB/TrEMBL
  A0A8D1T6G7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2CBH7 ENTREZGENE, UniProtKB/TrEMBL
  F1SIB6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89820 ENTREZGENE