TREM2 (triggering receptor expressed on myeloid cells 2)

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Gene: TREM2 (triggering receptor expressed on myeloid cells 2) Sus scrofa

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Symbol:

TREM2

Name:

triggering receptor expressed on myeloid cells 2

RGD ID:

13920360

Description:

ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); lipoteichoic acid binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); astrocyte activation (ortholog); cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 17 (ortholog); dementia (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH zearalenone

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	36,465,324 - 36,471,516 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	36,465,921 - 36,471,509 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	41,763,412 - 41,767,191 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Alzheimer's disease 17 (ISO)

dementia (ISO)

frontotemporal dementia (ISO)

genetic disease (ISO)

infantile Refsum disease (ISO)

Nasu-Hakola disease (ISO)

Neurosyphilis (ISO)

Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy 2 (ISO)

syphilis (ISO)

Zellweger syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

zearalenone (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid-beta clearance (IEA)

amyloid-beta clearance by cellular catabolic process (IEA)

apoptotic cell clearance (ISO)

astrocyte activation (ISO)

cellular response to amyloid-beta (IEA)

cellular response to glucose stimulus (ISO)

cellular response to hypoxia (ISO)

cellular response to lipid (IEA)

cellular response to lipoprotein particle stimulus (IEA)

cellular response to lipoteichoic acid (ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (IEA)

cellular response to peptidoglycan (ISO)

complement-mediated synapse pruning (ISO)

CXCL12-activated CXCR4 signaling pathway (IEA,ISO)

defense response to bacterium (ISO)

defense response to Gram-negative bacterium (ISO)

dendritic cell differentiation (IEA)

dendritic spine maintenance (ISO)

detection of lipopolysaccharide (ISO)

detection of lipoteichoic acid (ISO)

detection of peptidoglycan (ISO)

excitatory synapse pruning (ISO)

import into cell (ISO)

lipid homeostasis (ISO)

memory (IEA,ISO)

microglial cell activation (ISO)

microglial cell activation involved in immune response (ISO)

microglial cell proliferation (ISO)

negative regulation of amyloid fibril formation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of astrocyte activation (ISO)

negative regulation of autophagic cell death (ISO)

negative regulation of autophagy (ISO)

negative regulation of canonical NF-kappaB signal transduction (ISO)

negative regulation of cell activation (ISO)

negative regulation of cholesterol storage (ISO)

negative regulation of cytokine production involved in inflammatory response (ISO)

negative regulation of fat cell proliferation (ISO)

negative regulation of glial cell apoptotic process (ISO)

negative regulation of inflammatory response to antigenic stimulus (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of macrophage colony-stimulating factor signaling pathway (IEA)

negative regulation of neuroinflammatory response (IEA)

negative regulation of NLRP3 inflammasome complex assembly (IEA,ISO)

negative regulation of p38MAPK cascade (ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

negative regulation of sequestering of triglyceride (ISO)

negative regulation of toll-like receptor 2 signaling pathway (ISO)

negative regulation of toll-like receptor 4 signaling pathway (ISO)

negative regulation of tumor necrosis factor production (ISO)

neuroinflammatory response (ISO)

osteoclast differentiation (IEA,ISO)

phagocytosis, engulfment (ISO)

phagocytosis, recognition (IEA)

positive regulation of amyloid-beta clearance (IEA)

positive regulation of antigen processing and presentation of peptide antigen via MHC class II (IEA)

positive regulation of ATP biosynthetic process (ISO)

positive regulation of C-C chemokine receptor CCR7 signaling pathway (IEA)

positive regulation of calcium-mediated signaling (IEA)

positive regulation of CAMKK-AMPK signaling cascade (ISO)

positive regulation of CD40 signaling pathway (IEA)

positive regulation of chemotaxis (ISO)

positive regulation of cholesterol efflux (ISO)

positive regulation of complement activation, classical pathway (ISO)

positive regulation of engulfment of apoptotic cell (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of establishment of protein localization (ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of high-density lipoprotein particle clearance (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of inward rectifier potassium channel activity (ISO)

positive regulation of kinase activity (ISO)

positive regulation of low-density lipoprotein particle clearance (ISO)

positive regulation of macrophage fusion (ISO)

positive regulation of microglial cell activation (IEA)

positive regulation of microglial cell migration (IEA)

positive regulation of neuroinflammatory response (ISO)

positive regulation of non-canonical NF-kappaB signal transduction (ISO)

positive regulation of osteoclast differentiation (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (IEA,ISO)

positive regulation of phagocytosis (IEA)

positive regulation of phagocytosis, engulfment (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of proteasomal protein catabolic process (ISO)

positive regulation of protein localization to plasma membrane (IEA)

positive regulation of protein phosphorylation (ISO)

positive regulation of protein secretion (IEA)

positive regulation of synapse pruning (IEA)

positive regulation of TOR signaling (ISO)

pyroptotic inflammatory response (ISO)

regulation of cytokine production involved in inflammatory response (ISO)

regulation of gene expression (ISO)

regulation of hippocampal neuron apoptotic process (ISO)

regulation of innate immune response (ISO)

regulation of interleukin-6 production (ISO)

regulation of intracellular signal transduction (ISO)

regulation of lipid metabolic process (IEA,ISO)

regulation of macrophage inflammatory protein 1 alpha production (ISO)

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (ISO)

regulation of peptidyl-tyrosine phosphorylation (ISO)

regulation of plasma membrane bounded cell projection organization (IEA)

regulation of resting membrane potential (ISO)

regulation of toll-like receptor 6 signaling pathway (ISO)

regulation of TOR signaling (ISO)

respiratory burst after phagocytosis (ISO)

response to axon injury (IEA)

response to ischemia (ISO)

semaphorin-plexin signaling pathway (ISO)

social behavior (IEA,ISO)

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

plasma membrane raft (IEA)

Molecular Function

amyloid-beta binding (IEA)

apolipoprotein A-I binding (IEA)

apolipoprotein binding (IEA)

beta-catenin binding (IEA)

high-density lipoprotein particle binding (IEA)

kinase activator activity (IEA)

lipopolysaccharide binding (ISO)

lipoprotein particle binding (IEA)

lipoteichoic acid binding (ISO)

low-density lipoprotein particle binding (IEA)

peptidoglycan binding (ISO)

phosphatidylethanolamine binding (IEA)

phosphatidylserine binding (IEA)

phospholipid binding (IEA)

protein binding (ISO)

protein tyrosine kinase binding (ISO)

protein-containing complex binding (IEA)

scaffold protein binding (IEA)

semaphorin receptor activity (ISO)

semaphorin receptor binding (ISO)

signaling receptor activity (IEA)

sulfatide binding (IEA)

transmembrane signaling receptor activity (IEA)

very-low-density lipoprotein particle binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TREM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	36,465,324 - 36,471,516 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	36,465,921 - 36,471,509 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	41,763,412 - 41,767,191 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TREM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	41,158,508 - 41,163,116 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	41,158,506 - 41,163,186 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	41,126,246 - 41,130,854 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	41,234,230 - 41,238,892 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	41,234,230 - 41,238,892	NCBI
Celera	6	42,678,948 - 42,683,624 (-)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	40,844,044 - 40,848,724 (-)	NCBI		HuRef
CHM1_1	6	41,129,139 - 41,133,819 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	40,987,077 - 40,991,685 (-)	NCBI		T2T-CHM13v2.0

Trem2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	48,653,429 - 48,659,304 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	48,653,429 - 48,661,175 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	48,346,401 - 48,352,276 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	48,346,401 - 48,354,147 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	48,485,726 - 48,491,598 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	47,811,968 - 47,817,840 (+)	NCBI		MGSCv36	mm8
Celera	17	51,775,275 - 51,781,147 (+)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	23.99	NCBI

Trem2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	20,145,215 - 20,151,797 (-)	NCBI		GRCr8
mRatBN7.2	9	12,647,605 - 12,654,190 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	12,647,259 - 12,654,170 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	21,160,724 - 21,167,248 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	26,226,948 - 26,233,472 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	24,616,230 - 24,622,771 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	14,611,541 - 14,618,076 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	14,611,561 - 14,618,013 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	8,059,023 - 8,065,585 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	8,059,020 - 8,065,484 (-)	NCBI
Celera	9	10,419,918 - 10,426,480 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Trem2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	7,780,679 - 7,785,697 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	7,780,886 - 7,785,597 (-)	NCBI	ChiLan1.0	ChiLan1.0

TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	55,643,268 - 55,647,978 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	51,513,212 - 51,517,926 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	40,735,483 - 40,740,208 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	42,043,887 - 42,048,578 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	42,043,900 - 42,048,578 (-)	Ensembl	panpan1.1		panPan2

TREML1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	9,915,692 - 9,928,322 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	9,915,677 - 9,928,174 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	9,945,665 - 9,950,515 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	10,395,282 - 10,400,132 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	10,395,285 - 10,407,772 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	9,927,392 - 9,932,242 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	10,009,135 - 10,013,985 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	10,104,147 - 10,108,997 (-)	NCBI		UU_Cfam_GSD_1.0

Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	45,295,126 - 45,300,504 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	18,659,815 - 18,663,940 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	18,659,725 - 18,665,406 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TREM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	30,965,091 - 30,999,073 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	30,994,357 - 30,999,087 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	41,158,611 - 41,163,469 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trem2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	17,643,363 - 17,648,231 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	17,643,397 - 17,649,255 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TREM2
165 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
9	2	21	1	2	1	6	5	21	3	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001256777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01011831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JQ247512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000060326 ⟹ ENSSSCP00000035270

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	36,465,324 - 36,471,516 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000063763 ⟹ ENSSSCP00000036723

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	36,464,034 - 36,471,516 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000078608 ⟹ ENSSSCP00000067931

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	36,465,324 - 36,469,999 (-)	Ensembl

RefSeq Acc Id:

NM_001256777 ⟹ NP_001243706

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	7	36,465,921 - 36,471,509 (-)	NCBI

Sequence:

show sequence

GTCAGTTCCTGTGGGCAGCGCCTGACAGGCTCGACGCTCTCCTTTCTGCAGTTCAAGGGAAAGA
CGAGATCTTGCACAAGGCGCCCCGACTCTGTCCTCCGCAAAGGAAGGAGGCCATGGAGACTCTG
GGGCTGCTCCTCCTGCTCTGGGTTGCAGAGCTGTCCCGGGCACACAACACCTCGGTGTTCCAGG
GCACGGCCGGCCAGTCCCTGCGGGTCTCCTGCTCCTACAACTCCTTGAAGCACTGGGGGAGACG
CAAAGCCTGGTGCCGCCAGCTGAGCGAAGAGGGCCTGTGCCAGCACGTGGTCAGCACCCACCCC
ACCTGGCTGTTGTCCTTCCTGAAGCGGCGCAACGGGAGCACGGCCATCACGGACGATGCCCTGG
GCGGCACACTCACCATTACGCTGCGCAATCTTCAAGCCCACGACGCTGGCCTCTACCAGTGCCA
GAGCCTCCACGGTAGCGAGGCCGACACCCTCAAGAAGGTCTTGGTGGAGGTGCTGGCTGACCCT
CTTGAATCCCAGTCCAAGAGCTTCCAGGATGTTCAGATGGAGCACAGCATCTCCAGGAACCTTT
CAGAGGAGAGCCTCTTCCCACCTACCTCCACCCTTTTCCTCCTGGCCTGCGTCTTTCTCAGCAA
GCTTCTAGTAGCCAGCGCCCTCTGGGCTGCAGCCTGGCATGGGCACAAACAGAGGACTTCCCCA
GCCGGTGGGCTGGACTGTGGCCGTGACCCAGGCGACCAGGACCAAACCCTGACAGATGAGCTTG
GCGAGAGCAGTGACCAGGACCAAACCTTGACAGAGCTAAGAGACACGTGAGAGAAGCGGAGAGG
CCAGCAGAGGTCTGCATGGACCAGCCCAGCCAGCACACTCACCCCTTGGCCACTGAGTCTCCTG
GTTCTGCTTTGGCAAAAGGCCACTCTGCCTGTACCCTGCTTCCTCTGGCCTCTGGAAGTGGAGA
TTTGTGTGTGTGTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001243706	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AEX66156	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000035270
	ENSSSCP00000035270.1
	ENSSSCP00000067931.1
	ENSSSCP00015004208.1
	ENSSSCP00025033576.1
	ENSSSCP00035011760.1
	ENSSSCP00040037291.1
	ENSSSCP00045013991.1
	ENSSSCP00050002891.1
	ENSSSCP00060031130.1
	ENSSSCP00065042375.1
	ENSSSCP00070002825.1
	ENSSSCP00070002835.1

RefSeq Acc Id:	NP_001243706 ⟸ NM_001256777
- Peptide Label:	precursor
- UniProtKB:	H2EZZ3 (UniProtKB/TrEMBL), A0A4X1SLI6 (UniProtKB/TrEMBL), A0A8D2CFX5 (UniProtKB/TrEMBL), A0A8D0Z9K4 (UniProtKB/TrEMBL)
- Sequence:	show sequence METLGLLLLLWVAELSRAHNTSVFQGTAGQSLRVSCSYNSLKHWGRRKAWCRQLSEEGLCQHVV STHPTWLLSFLKRRNGSTAITDDALGGTLTITLRNLQAHDAGLYQCQSLHGSEADTLKKVLVEV LADPLESQSKSFQDVQMEHSISRNLSEESLFPPTSTLFLLACVFLSKLLVASALWAAAWHGHKQ RTSPAGGLDCGRDPGDQDQTLTDELGESSDQDQTLTELRDT hide sequence

Ensembl Acc Id:

ENSSSCP00000067931 ⟸ ENSSSCT00000078608

Ensembl Acc Id:

ENSSSCP00000035270 ⟸ ENSSSCT00000060326

Ensembl Acc Id:

ENSSSCP00000036723 ⟸ ENSSSCT00000063763

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000039270	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015008085	UniProtKB/TrEMBL
	ENSSSCG00025056611	UniProtKB/TrEMBL
	ENSSSCG00035023089	UniProtKB/TrEMBL
	ENSSSCG00040062587	UniProtKB/TrEMBL
	ENSSSCG00045011996	UniProtKB/TrEMBL
	ENSSSCG00050004891	UniProtKB/TrEMBL
	ENSSSCG00060052999	UniProtKB/TrEMBL
	ENSSSCG00065070447	UniProtKB/TrEMBL
	ENSSSCG00070001824	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000060326	ENTREZGENE
	ENSSSCT00000060326.2	UniProtKB/TrEMBL
	ENSSSCT00000078608.1	UniProtKB/TrEMBL
	ENSSSCT00015010685.1	UniProtKB/TrEMBL
	ENSSSCT00025077469.1	UniProtKB/TrEMBL
	ENSSSCT00035030232.1	UniProtKB/TrEMBL
	ENSSSCT00040085291.1	UniProtKB/TrEMBL
	ENSSSCT00045020373.1	UniProtKB/TrEMBL
	ENSSSCT00050006717.1	UniProtKB/TrEMBL
	ENSSSCT00060072158.1	UniProtKB/TrEMBL
	ENSSSCT00065096767.1	UniProtKB/TrEMBL
	ENSSSCT00070003412.1	UniProtKB/TrEMBL
	ENSSSCT00070003425.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
	Immune_rcpt_domain	UniProtKB/TrEMBL
KEGG Report	ssc:100737974	UniProtKB/TrEMBL
NCBI Gene	TREM2	ENTREZGENE
PANTHER	IG-LIKE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	TREM-LIKE TRANSCRIPT PROTEIN	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A4X1SLH6_PIG	UniProtKB/TrEMBL
	A0A4X1SLI6	ENTREZGENE
	A0A5G2R144_PIG	UniProtKB/TrEMBL
	A0A8D0Z9K4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D2CFX5	ENTREZGENE, UniProtKB/TrEMBL
	H2EZZ3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A4X1SLI6	UniProtKB/TrEMBL
VGNC ID	VGNC:94384	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM