DLG4 (discs large MAGUK scaffold protein 4) - Rat Genome Database

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Gene: DLG4 (discs large MAGUK scaffold protein 4) Sus scrofa
Analyze
Symbol: DLG4
Name: discs large MAGUK scaffold protein 4
RGD ID: 14016624
Description: ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); beta-1 adrenergic receptor binding (ortholog); beta-2 adrenergic receptor binding (ortholog); INVOLVED IN dendritic spine organization (ortholog); negative regulation of receptor internalization (ortholog); positive regulation of AMPA glutamate receptor clustering (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); Autosomal Dominant Mental Retardation 62 (ortholog); FOUND IN anchored component of postsynaptic density membrane (ortholog); cell junction (ortholog); cell periphery (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: disks large homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,550,141 - 52,575,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,550,138 - 52,574,021 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,824,633 - 139,849,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
DLG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,550,141 - 52,575,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,550,138 - 52,574,021 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,824,633 - 139,849,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl177,187,187 - 7,219,841 (-)EnsemblGRCh38hg38GRCh38
GRCh38177,187,187 - 7,220,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,090,506 - 7,123,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,033,933 - 7,063,781 (-)NCBINCBI36hg18NCBI36
Build 34177,033,935 - 7,063,745NCBI
Celera177,117,875 - 7,148,003 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef176,984,911 - 7,015,359 (-)NCBIHuRef
CHM1_1177,102,006 - 7,132,134 (-)NCBICHM1_1
Dlg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,908,029 - 69,938,107 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,907,768 - 69,938,348 (+)Ensembl
GRCm381170,017,203 - 70,045,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,016,942 - 70,047,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,832,107 - 69,859,034 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,835,059 - 69,860,963 (+)NCBImm8
Celera1177,566,529 - 77,594,216 (+)NCBICelera
Cytogenetic Map11B3NCBI
Dlg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,740,700 - 54,769,097 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1056,627,411 - 56,653,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01056,625,845 - 56,655,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,369,703 - 56,400,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,864,459 - 56,890,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,878,081 - 56,904,246 (+)NCBI
Celera1053,894,685 - 53,920,691 (+)NCBICelera
Cytogenetic Map10q24NCBI
Dlg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,690,469 - 9,715,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,691,733 - 9,715,872 (+)NCBIChiLan1.0ChiLan1.0
DLG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,207,483 - 7,236,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,207,483 - 7,235,985 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,219,911 - 7,247,509 (-)NCBIMhudiblu_PPA_v0panPan3
DLG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,165,399 - 32,175,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,163,594 - 32,188,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,303,501 - 32,327,281 (-)NCBI
ROS_Cfam_1.0532,271,402 - 32,294,586 (-)NCBI
UMICH_Zoey_3.1532,236,680 - 32,259,896 (-)NCBI
UNSW_CanFamBas_1.0532,195,151 - 32,218,943 (-)NCBI
UU_Cfam_GSD_1.0532,372,643 - 32,395,864 (-)NCBI
Dlg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,013,899 - 47,039,640 (-)NCBI
SpeTri2.0NW_004936595487,918 - 513,843 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,562,953 - 6,592,247 (-)NCBI
ChlSab1.1 Ensembl166,562,691 - 6,590,867 (-)Ensembl
Vero_WHO_p1.0NW_02366605914,818,727 - 14,848,070 (+)NCBI
Dlg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247869,811,201 - 9,835,660 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 18
Low 7 2 3 5 2 5 3 2
Below cutoff 3 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000022437   ⟹   ENSSSCP00000026725
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,143 - 52,573,623 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000031364   ⟹   ENSSSCP00000025399
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,141 - 52,568,951 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000057407   ⟹   ENSSSCP00000049514
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,141 - 52,570,235 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000063962   ⟹   ENSSSCP00000035160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,143 - 52,573,625 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000066654   ⟹   ENSSSCP00000071614
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,142 - 52,564,583 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000068331   ⟹   ENSSSCP00000071524
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,551,975 - 52,562,383 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075042   ⟹   ENSSSCP00000073446
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,560,560 - 52,575,156 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087897   ⟹   ENSSSCP00000072612
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,550,143 - 52,575,143 (-)Ensembl
RefSeq Acc Id: XM_003481294   ⟹   XP_003481342
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,574,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005655280   ⟹   XP_005655337
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,573,940 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987943   ⟹   XP_013843397
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,573,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987944   ⟹   XP_013843398
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,568,865 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987945   ⟹   XP_013843399
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,568,865 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987946   ⟹   XP_013843400
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,573,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987947   ⟹   XP_013843401
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,573,940 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013987948   ⟹   XP_013843402
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,566,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067810   ⟹   XP_020923469
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,550,138 - 52,565,739 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003481342   ⟸   XM_003481294
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_013843397   ⟸   XM_013987943
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005655337   ⟸   XM_005655280
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_013843401   ⟸   XM_013987947
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013843400   ⟸   XM_013987946
- Peptide Label: isoform X5
- UniProtKB: A0A287B083 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013843399   ⟸   XM_013987945
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013843398   ⟸   XM_013987944
- Peptide Label: isoform X3
- UniProtKB: I3LMS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013843402   ⟸   XM_013987948
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020923469   ⟸   XM_021067810
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000071524   ⟸   ENSSSCT00000068331
RefSeq Acc Id: ENSSSCP00000073446   ⟸   ENSSSCT00000075042
RefSeq Acc Id: ENSSSCP00000025399   ⟸   ENSSSCT00000031364
RefSeq Acc Id: ENSSSCP00000071614   ⟸   ENSSSCT00000066654
RefSeq Acc Id: ENSSSCP00000026725   ⟸   ENSSSCT00000022437
RefSeq Acc Id: ENSSSCP00000072612   ⟸   ENSSSCT00000087897
RefSeq Acc Id: ENSSSCP00000035160   ⟸   ENSSSCT00000063962
RefSeq Acc Id: ENSSSCP00000049514   ⟸   ENSSSCT00000057407
Protein Domains
Guanylate kinase-like   PDZ   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020664 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000025399 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000026725 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000035160 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049514 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000071524 UniProtKB/TrEMBL
  ENSSSCP00000071614 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000072612 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000073446 UniProtKB/TrEMBL
  ENSSSCP00070034734 UniProtKB/TrEMBL
  ENSSSCP00070034768 UniProtKB/TrEMBL
  ENSSSCP00070034786 UniProtKB/TrEMBL
  ENSSSCP00070034796 UniProtKB/TrEMBL
  ENSSSCP00070034805 UniProtKB/TrEMBL
  ENSSSCP00070034812 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022437 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000031364 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000057407 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000063962 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066654 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000068331 UniProtKB/TrEMBL
  ENSSSCT00000075042 UniProtKB/TrEMBL
  ENSSSCT00000087897 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070041381 UniProtKB/TrEMBL
  ENSSSCT00070041416 UniProtKB/TrEMBL
  ENSSSCT00070041435 UniProtKB/TrEMBL
  ENSSSCT00070041447 UniProtKB/TrEMBL
  ENSSSCT00070041457 UniProtKB/TrEMBL
  ENSSSCT00070041467 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/TrEMBL
  DLG1_PEST_dom UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report ssc:100626077 UniProtKB/TrEMBL
NCBI Gene DLG4 ENTREZGENE
Pfam Guanylate_kin UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PIRSF MAGUK_DLGH UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A286ZUM2_PIG UniProtKB/TrEMBL
  A0A287B083 ENTREZGENE, UniProtKB/TrEMBL
  A0A480XRH0_PIG UniProtKB/TrEMBL
  A0A4X1UX18_PIG UniProtKB/TrEMBL
  A0A4X1UX54_PIG UniProtKB/TrEMBL
  A0A4X1UZJ9_PIG UniProtKB/TrEMBL
  A0A4X1V1A7_PIG UniProtKB/TrEMBL
  A0A4X1V294_PIG UniProtKB/TrEMBL
  A0A4X1V2A5_PIG UniProtKB/TrEMBL
  A0A5G2R5C8_PIG UniProtKB/TrEMBL
  A0A5G2R8N4_PIG UniProtKB/TrEMBL
  A0A5G2RIW1_PIG UniProtKB/TrEMBL
  A0A5G2RKH3_PIG UniProtKB/TrEMBL
  I3LMS7 ENTREZGENE, UniProtKB/TrEMBL
  I3LRJ0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87328 ENTREZGENE