DSP (desmoplakin) - Rat Genome Database

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Gene: DSP (desmoplakin) Sus scrofa
Analyze
Symbol: DSP
Name: desmoplakin
RGD ID: 13975954
Description: ENCODES a protein that exhibits metal ion binding (inferred); protein kinase C binding (inferred); scaffold protein binding (inferred); INVOLVED IN adherens junction organization (ortholog); cell-cell adhesion (ortholog); desmosome organization (ortholog); ASSOCIATED WITH amyloidosis (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); FOUND IN desmosome (ortholog); fascia adherens (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl74,862,649 - 4,915,623 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.174,862,649 - 4,915,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.274,968,344 - 5,021,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amyloidosis  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 8  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2J  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
cardiomyopathy  (ISO)
Carvajal syndrome  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
chronic obstructive pulmonary disease  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dilated Cardiomyopathy with Woolly Hair, Keratoderma, and Tooth Agenesis  (ISO)
Ectodermal Dysplasia-Skin Fragility Syndrome  (ISO)
Epidermolysis Bullosa, Lethal Acantholytic  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hemiplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
idiopathic pulmonary fibrosis  (ISO)
keratosis palmoplantaris striata 2  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
lung disease  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
migraine  (ISO)
myocarditis  (ISO)
PALMOPLANTAR KERATODERMA AND WOOLLY HAIR  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
progressive familial heart block  (ISO)
pulmonary fibrosis  (ISO)
restrictive cardiomyopathy  (ISO)
subvalvular aortic stenosis  (ISO)
Subvalvular Aortic Stenosis, Eisenberg Type  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Syncope  (ISO)
systolic heart failure  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl74,862,649 - 4,915,623 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.174,862,649 - 4,915,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.274,968,344 - 5,021,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3867,541,671 - 7,586,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,541,338 - 7,586,714 (+)EnsemblGRCh38hg38GRCh38
GRCh3767,541,904 - 7,586,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,486,869 - 7,531,945 (+)NCBINCBI36Build 36hg18NCBI36
Build 3467,486,868 - 7,531,945NCBI
Celera68,771,623 - 8,816,711 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,419,476 - 7,464,417 (+)NCBIHuRef
CHM1_167,544,023 - 7,589,106 (+)NCBICHM1_1
T2T-CHM13v2.067,410,711 - 7,455,759 (+)NCBIT2T-CHM13v2.0
Dsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,335,357 - 38,382,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,335,270 - 38,382,553 (+)EnsemblGRCm39 Ensembl
GRCm381338,151,294 - 38,198,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,151,294 - 38,198,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,243,163 - 38,290,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361338,158,760 - 38,206,043 (+)NCBIMGSCv36mm8
Celera1339,265,897 - 39,313,259 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.0NCBI
Dsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,829,153 - 26,877,419 (-)NCBIGRCr8
mRatBN7.21726,623,602 - 26,671,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01727,286,811 - 27,334,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01729,201,872 - 29,249,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,848,313 - 32,896,044 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,851,800 - 32,898,885 (-)NCBI
Celera1726,257,726 - 26,305,766 (-)NCBICelera
Cytogenetic Map17p12NCBI
Dsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,356,863 - 6,392,207 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,356,970 - 6,391,206 (-)NCBIChiLan1.0ChiLan1.0
DSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2522,183,206 - 22,228,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,180,000 - 18,225,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,381,046 - 7,426,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,664,399 - 7,709,391 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,664,211 - 7,709,391 (+)Ensemblpanpan1.1panPan2
DSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,479,628 - 7,524,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,479,643 - 7,524,044 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,483,107 - 7,528,345 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,562,265 - 7,607,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,562,020 - 7,607,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,415,316 - 7,460,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,441,523 - 7,486,395 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,773,585 - 8,819,012 (+)NCBIUU_Cfam_GSD_1.0
Dsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,760,022 - 16,807,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365345,028,911 - 5,077,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365345,029,008 - 5,076,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,611,243 - 64,656,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,611,103 - 64,656,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660447,495,774 - 7,541,054 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475618,035,892 - 18,083,336 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475618,036,103 - 18,083,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DSP
2976 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 2 1 3 1
Low 3 2 3 4 2 23 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001118   ⟹   ENSSSCP00000001096
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl74,862,994 - 4,915,623 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000063188   ⟹   ENSSSCP00000040779
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl74,862,649 - 4,915,126 (+)Ensembl
RefSeq Acc Id: XM_003128168   ⟹   XP_003128216
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.174,862,901 - 4,915,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100158   ⟹   XP_020955817
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.174,862,649 - 4,915,626 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020955817   ⟸   XM_021100158
- Peptide Label: isoform X2
- UniProtKB: A0A8D0STU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003128216   ⟸   XM_003128168
- Peptide Label: isoform X1
- UniProtKB: F1RW75 (UniProtKB/TrEMBL),   A0A8D1A3U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001096   ⟸   ENSSSCT00000001118
RefSeq Acc Id: ENSSSCP00000040779   ⟸   ENSSSCT00000063188
Protein Domains
CHHC U11-48K-type   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001025 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025061458 UniProtKB/TrEMBL
  ENSSSCG00035052288 UniProtKB/TrEMBL
  ENSSSCG00045018107 UniProtKB/TrEMBL
  ENSSSCG00055023638 UniProtKB/TrEMBL
  ENSSSCG00070001158 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001118 ENTREZGENE
  ENSSSCT00000001118.5 UniProtKB/TrEMBL
  ENSSSCT00000063188 ENTREZGENE
  ENSSSCT00000063188.2 UniProtKB/TrEMBL
  ENSSSCT00025084542.1 UniProtKB/TrEMBL
  ENSSSCT00035069686.1 UniProtKB/TrEMBL
  ENSSSCT00035069708.1 UniProtKB/TrEMBL
  ENSSSCT00045030878.1 UniProtKB/TrEMBL
  ENSSSCT00055046552.1 UniProtKB/TrEMBL
  ENSSSCT00055046778.1 UniProtKB/TrEMBL
  ENSSSCT00070002203.1 UniProtKB/TrEMBL
  ENSSSCT00070002310.1 UniProtKB/TrEMBL
  ENSSSCT00070002317.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1060 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  3.30.160.780 UniProtKB/TrEMBL
  3.90.1290.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Desmoplakin_SH3 UniProtKB/TrEMBL
  Desmoplakin_Spectrin-like UniProtKB/TrEMBL
  Plakin UniProtKB/TrEMBL
  Plakin_repeat_sf UniProtKB/TrEMBL
  Plectin_repeat UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  TRM13/UPF0224_CHHC_Znf_dom UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene DSP ENTREZGENE
PANTHER PTHR21402:SF10 UniProtKB/TrEMBL
  PTHR23169 UniProtKB/TrEMBL
  PTHR23169:SF26 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam Plectin UniProtKB/TrEMBL
  SH3_10 UniProtKB/TrEMBL
  Spectrin_3 UniProtKB/TrEMBL
  Spectrin_like UniProtKB/TrEMBL
  zf-U11-48K UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
  ZF_CHHC_U11_48K UniProtKB/TrEMBL
SMART PLEC UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
  SSF75399 UniProtKB/TrEMBL
UniProt A0A287AA14_PIG UniProtKB/TrEMBL
  A0A4X1SHQ7_PIG UniProtKB/TrEMBL
  A0A4X1SI11_PIG UniProtKB/TrEMBL
  A0A4X1SJ90_PIG UniProtKB/TrEMBL
  A0A8D0STU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1A3U5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HQB9_PIG UniProtKB/TrEMBL
  A0A8D1RJ05_PIG UniProtKB/TrEMBL
  F1RW75 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87459 ENTREZGENE