CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) - Rat Genome Database

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Gene: CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Sus scrofa
Analyze
Symbol: CHRNA7
Name: cholinergic receptor nicotinic alpha 7 subunit
RGD ID: 14264013
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); associative learning (ortholog); B cell activation (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH Alzheimer's disease (ortholog); Auditory Perceptual Disorders (ortholog); autism spectrum disorder (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); asymmetric synapse (ortholog); axon (ortholog); INTERACTS WITH (S)-nicotine; carbon dioxide; dioxygen
Type: protein-coding
RefSeq Status: MODEL
Also known as: cholinergic receptor nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); neuronal acetylcholine receptor subunit alpha-7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,698 - 142,937,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
associative learning  (IEA,ISO)
B cell activation  (IEA,ISO)
behavioral response to ethanol  (IEA,ISO)
behavioral response to nicotine  (IEA,ISO)
calcium ion transport  (ISO)
cellular calcium ion homeostasis  (ISO)
chemical synaptic transmission  (IBA)
cognition  (ISO)
dendrite arborization  (IEA)
dendritic spine organization  (IEA)
dopamine biosynthetic process  (ISO)
endocytosis  (IEA,ISO)
excitatory postsynaptic potential  (IEA)
flagellated sperm motility  (IEA,ISO)
generation of ovulation cycle rhythm  (IEA,ISO)
ion transmembrane transport  (IBA,IEA,ISO)
ion transport  (ISO)
learning or memory  (ISO)
memory  (IEA,ISO)
modulation of chemical synaptic transmission  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of protein phosphorylation  (IEA)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nervous system process  (IBA)
neuronal action potential  (ISO)
ovulation cycle  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (IEA)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of amyloid fibril formation  (IEA)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (ISO)
regulation of membrane potential  (IBA,ISO)
regulation of neuron death  (IEA)
regulation of norepinephrine secretion  (IEA,ISO)
regulation of response to drug  (ISO)
regulation of synaptic transmission, dopaminergic  (IEA,ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to acetylcholine  (ISO)
response to amyloid-beta  (IEA)
response to cold  (IEA)
response to ethanol  (ISO)
response to food  (IEA,ISO)
response to hypoxia  (ISO)
response to nicotine  (ISO)
sensory processing  (IEA)
signal transduction  (IBA)
synapse organization  (ISO)
synaptic transmission, cholinergic  (IBA,IEA,ISO)
T cell activation  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20857232  


Genomics

Comparative Map Data
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,698 - 142,937,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,030,462 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371532,322,686 - 32,465,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)Ensembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21116,715,286 - 116,837,223 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)Ensembl
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Celera1108,976,664 - 109,097,764 (-)NCBICelera
Cytogenetic Map1q22NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
CHRNA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11529,565,885 - 29,705,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0panPan3
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha339,517,659 - 39,644,156 (-)NCBI
ROS_Cfam_1.0337,232,973 - 37,359,572 (-)NCBI
UMICH_Zoey_3.1336,756,424 - 36,882,829 (-)NCBI
UNSW_CanFamBas_1.0337,011,929 - 37,138,401 (-)NCBI
UU_Cfam_GSD_1.0337,222,873 - 37,349,426 (-)NCBI
Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBI
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0
Chrna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system
High
Medium
Low 2 1 19
Below cutoff 5 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005341   ⟹   ENSSSCP00000005209
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1142,803,698 - 142,937,123 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062842   ⟹   ENSSSCP00000049873
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1142,807,768 - 142,937,123 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084783   ⟹   ENSSSCP00000069248
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1142,803,698 - 142,937,788 (-)Ensembl
RefSeq Acc Id: XM_021098695   ⟹   XP_020954354
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020954354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADE28530 (Get FASTA)   NCBI Sequence Viewer  
  AEW68338 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020954354   ⟸   XM_021098695
- Sequence:
RefSeq Acc Id: ENSSSCP00000005209   ⟸   ENSSSCT00000005341
RefSeq Acc Id: ENSSSCP00000069248   ⟸   ENSSSCT00000084783
RefSeq Acc Id: ENSSSCP00000049873   ⟸   ENSSSCT00000062842
Protein Domains
Neur_chan_LBD   Neur_chan_memb


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004839 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070015888 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000005209 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049873 UniProtKB/TrEMBL
  ENSSSCP00000069248 UniProtKB/TrEMBL
  ENSSSCP00070026002 UniProtKB/TrEMBL
  ENSSSCP00070026016 UniProtKB/TrEMBL
  ENSSSCP00070026019 UniProtKB/TrEMBL
  ENSSSCP00070026032 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005341 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000062842 UniProtKB/TrEMBL
  ENSSSCT00000084783 UniProtKB/TrEMBL
  ENSSSCT00070031198 UniProtKB/TrEMBL
  ENSSSCT00070031211 UniProtKB/TrEMBL
  ENSSSCT00070031216 UniProtKB/TrEMBL
  ENSSSCT00070031229 UniProtKB/TrEMBL
Gene3D-CATH 2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA7 ENTREZGENE
PANTHER PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/TrEMBL
UniProt A0A287B0C8_PIG UniProtKB/TrEMBL
  A0A4X1U8B8_PIG UniProtKB/TrEMBL
  A0A4X1UAQ8_PIG UniProtKB/TrEMBL
  A0A4X1UCK5_PIG UniProtKB/TrEMBL
  A0A4X1UDP2_PIG UniProtKB/TrEMBL
  A0A5G2QYM8_PIG UniProtKB/TrEMBL
  D5K892_PIG UniProtKB/TrEMBL
  F1SNR6_PIG UniProtKB/TrEMBL
  G9JX30_PIG UniProtKB/TrEMBL