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ONTOLOGY REPORT - ANNOTATIONS

Term:hepatocyte differentiation
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Accession:GO:0070365 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
Synonyms:exact_synonym: liver cell differentiation


show annotations for term's descendants           Sort by:
hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 IEP RGD PMID:11668598 RGD:2306909 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEP RGD PMID:12939595 RGD:4144098 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP RGD PMID:17574236 RGD:2306655 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G E2f7 E2F transcription factor 7 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23064266)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23064266 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734 		JBrowse link
G E2f8 E2F transcription factor 8 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23064264), (PMID:23064266)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23064264 PMID:23064266 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Foxh1 forkhead box H1 IEP RGD PMID:22715131 RGD:155791677 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049 		JBrowse link
G Frzb frizzled-related protein acts_upstream_of ISO (PMID:19562671) RGD PMID:19562671 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IEP RGD PMID:10934156 RGD:14701049 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO MGI:2448661 (PMID:11027604) RGD PMID:11027604 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Hnf1b HNF1 homeobox B IEP RGD PMID:18286537 RGD:2312718 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IEP RGD PMID:19621519 RGD:12904750 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Itga2 integrin subunit alpha 2 IEP RGD PMID:16458388 RGD:2307397 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Krt18 keratin 18 IEP RGD PMID:24340101 PMID:28941653 RGD:27226712, RGD:27226713 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:15232737) RGD PMID:15232737 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 acts_upstream_of_or_within ISO MGI:2387974 (PMID:16138077) RGD PMID:16138077 NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,741,477...12,763,620 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 acts_upstream_of_or_within ISO MGI:2176946|MGI:3606185 (PMID:18722179) RGD PMID:18722179 NCBI chr 1:169,506,940...169,508,234
Ensembl chr 1:160,095,108...160,096,376 		JBrowse link
G Wnt1 Wnt family member 1 IMP RGD PMID:20413689 RGD:2326223 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled-related protein acts_upstream_of_or_within ISO (PMID:19562671) RGD PMID:19562671 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
positive regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:19229878 RGD:8885195 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Foxa3 forkhead box A3 IMP RGD PMID:9878541 RGD:2315086 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18593560) RGD PMID:18593560 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      cellular developmental process 4831
        cell differentiation 4830
          epithelial cell differentiation 858
            hepatocyte differentiation 22
              negative regulation of hepatocyte differentiation 1
              positive regulation of hepatocyte differentiation 3
              regulation of hepatocyte differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 20553
    developmental process 7140
      anatomical structure development 6638
        multicellular organism development 5350
          system development 4630
            hepaticobiliary system development 294
              liver development 291
                hepatocyte differentiation 22
                  negative regulation of hepatocyte differentiation 1
                  positive regulation of hepatocyte differentiation 3
                  regulation of hepatocyte differentiation + 4
paths to the root