RGD Reference Report - Annexin expressions are temporally and spatially regulated during rat hepatocyte differentiation. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Annexin expressions are temporally and spatially regulated during rat hepatocyte differentiation.

Authors: Della Gaspera, B  Braut-Boucher, F  Bomsel, M  Chatelet, F  Guguen-Guillouzo, C  Font, J  Weinman, J  Weinman, S 
Citation: Della Gaspera B, etal., Dev Dyn. 2001 Oct;222(2):206-17.
RGD ID: 2306909
Pubmed: (View Article at PubMed) PMID:11668598
DOI: Full-text: DOI:10.1002/dvdy.1183

Annexin (Anx) 1, 2, 5, and 6 expressions were determined at the transcriptional and translational levels in the rat hepatocytes from gestational day 15 to postnatal day 17. Dramatic shifts were observed in Anx 1 and 2 levels, which peaked at day 1 and gestational day 20, respectively, and reached low levels thereafter. However, Anx 5 and 6 rates were more constant. Prenatal administration of dexamethasone (dex) resulted in a decrease of Anx 1 mRNA levels, and a strong increase in Anx 2 mRNA contents. In adult hepatocytes cultured in the presence of EGF or HGF, Anx 1 and 2 expressions resumed. By immunohistochemistry, Anx 1 was detected only in the cytoplasm of hepatocytes of 1- to 3-day-old rats, Anx 2 and 6 both exhibited a redistribution from the cytoplasm toward the plasma membrane, and Anx 5 was present in the nucleus, cytoplasm, and plasma membrane. Thus, Anx 1, 2, 5, and 6 have individual modes of expression and localization in the differentiating hepatocytes, where they might play unique roles at well defined phases of liver ontogeny.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Anxa1  (annexin A1)


Additional Information