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ONTOLOGY REPORT - ANNOTATIONS

Term:C21-steroid hormone biosynthetic process
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Accession:GO:0006700 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
Synonyms:exact_synonym: C21-steroid hormone anabolism;   C21-steroid hormone biosynthesis;   C21-steroid hormone formation;   C21-steroid hormone synthesis


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C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA
IEA		 pregnenolone
(PMID:7527351)
GO_REF:0000033
GO_REF:0000107
(PMID:11502818), (PMID:18182448), (PMID:21636783)		 RGD
GO_Central
Ensembl		 PMID:7527351 PMID:11502818 PMID:18182448 PMID:21636783 PMID:19665544 GO_REF:0000033 GO_REF:0000107, RGD:4891164 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
ISO		 (PMID:2256920) RGD PMID:2256920 PMID:11832364 RGD:727991 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in ISO (PMID:2256920) RGD PMID:2256920 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 IMP RGD PMID:9408081 RGD:1298842 NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 IDA RGD PMID:1985917 RGD:632871 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO		 PMID:19342457
GO_REF:0000107
(PMID:19342457)		 Ensembl
RGD		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP
IBA		 PMID:19342457
GO_REF:0000033		 GO_Central PMID:19342457 GO_REF:0000033, RGD:4891166 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
IBA
ISO		 GO_REF:0000033
(PMID:19342457), (PMID:2256920)		 GO_Central
RGD		 PMID:2256920 PMID:19342457 PMID:11832364 GO_REF:0000033, RGD:727991 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:1741400), (PMID:19342457), (PMID:2256920), (PMID:23322723)
(PMID:1686470), (PMID:8645611)		 RGD PMID:1686470 PMID:1741400 PMID:2256920 PMID:8645611 PMID:19342457 More... NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19584291)		 Ensembl
RGD		 PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:16527843) RGD PMID:16527843 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha IMP RGD PMID:20133449 RGD:10059648 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IDA RGD PMID:1955079 RGD:1625116 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:1703300) RGD PMID:1703300 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287 		JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 acts_upstream_of_or_within ISO MGI:3042568 (PMID:14963026) RGD PMID:14963026 NCBI chr10:83,357,329...83,379,873
Ensembl chr10:83,357,359...83,550,976 		JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO
ISS		 (PMID:29403011)
GO_REF:0000024		 RGD
UniProt		 PMID:29403011 GO_REF:0000024 NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657 		JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G Egr1 early growth response 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:82584|PMID:8703054)		 UniProt
Ensembl
RGD		 PMID:8703054 GO_REF:0000024 GO_REF:0000107 MGI:82584 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:23045399 RGD:26884342 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir455 microRNA 455 IDA RGD PMID:23045399 RGD:26884342 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18168
      C21-steroid hormone metabolic process 45
        C21-steroid hormone biosynthetic process 25
          aldosterone biosynthetic process + 12
          progesterone biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11455
      primary metabolic process 10131
        lipid metabolic process 1463
          lipid biosynthetic process 716
            steroid biosynthetic process 184
              steroid hormone biosynthetic process 45
                C21-steroid hormone biosynthetic process 25
                  aldosterone biosynthetic process + 12
                  progesterone biosynthetic process + 9
paths to the root