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ONTOLOGY REPORT - ANNOTATIONS


Term:C21-steroid hormone metabolic process
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Accession:GO:0008207 term browser browse the term
Definition:The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
Synonyms:exact_synonym: C21-steroid hormone metabolism


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C21-steroid hormone metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:13792537
G Akr1c14 aldo-keto reductase family 1, member C14 JBrowse link 17 69,806,095 69,827,125 RGD:13792537
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:13792537
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:13792537
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:1600115
RGD:1624291
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:4889515
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:1599722
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889515
RGD:13792537
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:13792537
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 JBrowse link 2 200,756,557 200,762,492 RGD:13792537
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 JBrowse link 2 200,615,910 200,633,317 RGD:13792537
G LOC108348086 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 JBrowse link 2 202,341,415 202,350,893 RGD:13792537
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase JBrowse link 17 69,468,427 69,497,132 RGD:13792537
aldosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:4891166
RGD:1600115
RGD:1624291
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4891166
RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
RGD:13792537
RGD:1624291
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1624291
C21-steroid hormone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4891164
RGD:13792537
RGD:1624291
RGD:1600115
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
RGD:13792537
RGD:1624291
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1624291
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:1298842
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:1600115
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:632871
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:4891166
RGD:1624291
RGD:1600115
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:7243836
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:10059648
progesterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:1625116
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:1624291
G Stard3 StAR-related lipid transfer domain containing 3 JBrowse link 10 86,313,430 86,335,868 RGD:1624291
progesterone catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:1624291
progesterone metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:1624291
RGD:1600115
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:13792537
G Akr1c14 aldo-keto reductase family 1, member C14 JBrowse link 17 69,806,095 69,827,125 RGD:13792537
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:1624291
RGD:13792537
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:2303525
RGD:13792537
RGD:1624291
RGD:1299435
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:1600115
RGD:13792537
RGD:1624291
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4891164
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 6 132,242,328 132,273,788 RGD:1624291
G Dhrs9 dehydrogenase/reductase 9 JBrowse link 3 55,623,671 55,645,883 RGD:1624291
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 JBrowse link 2 200,615,910 200,633,317 RGD:2303525
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase JBrowse link 17 69,468,427 69,497,132 RGD:13792537
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:4892033
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
regulation of aldosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcn2 chloride voltage-gated channel 2 JBrowse link 11 82,862,664 82,876,165 RGD:1600115
RGD:1624291
G LOC108348101 chloride channel protein 2 JBrowse link 11 83,883,428 83,897,396 RGD:1600115
regulation of aldosterone metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 JBrowse link 15 344,204 1,048,849 RGD:1624291
regulation of progesterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:1624291
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:1600115
RGD:1624291
G Mir125a microRNA 125a JBrowse link 1 59,704,827 59,704,911 RGD:26884342
G Mir455 microRNA 455 JBrowse link 5 79,097,208 79,097,285 RGD:26884342

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      hormone metabolic process 213
        cellular hormone metabolic process 126
          C21-steroid hormone metabolic process 43
            C21-steroid hormone biosynthetic process + 25
            C21-steroid hormone catabolic process + 1
            aldosterone metabolic process + 14
            progesterone metabolic process + 21
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological quality 4252
        regulation of hormone levels 584
          hormone metabolic process 213
            cellular hormone metabolic process 126
              C21-steroid hormone metabolic process 43
                C21-steroid hormone biosynthetic process + 25
                C21-steroid hormone catabolic process + 1
                aldosterone metabolic process + 14
                progesterone metabolic process + 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.