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ONTOLOGY REPORT - ANNOTATIONS


Term:C21-steroid hormone metabolic process
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Accession:GO:0008207 term browser browse the term
Definition:The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
Synonyms:exact_synonym: C21-steroid hormone metabolism


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C21-steroid hormone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in ISO
IEA
(PMID:7508385)
GO_REF:0000107
RGD
Ensembl
PMID:7508385 GO_REF:0000107 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IDA 7-dehydropregnenolone RGD PMID:19190754 RGD:4889515 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IMP RGD PMID:14563706 RGD:1599722 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12917011)
UniProt
Ensembl
RGD
PMID:12917011 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 involved_in IDA
IBA
7-dehydropregnenolone
PMID:21873635
RGD
GO_Central
PMID:19190754, PMID:21873635 RGD:4889515, RGD:13792537
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:200,615,910...200,633,317
Ensembl chr 2:200,584,986...200,692,335
JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO
PMID:19342457
GO_REF:0000107
(PMID:19342457)
Ensembl
RGD
PMID:19342457, PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP
IBA
PMID:19342457
PMID:21873635
UniProt
GO_Central
PMID:19342457, PMID:21873635 RGD:4891166, RGD:13792537 NCBI chr 7:116,195,976...116,201,829 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
ISO
IBA
(PMID:19342457), (PMID:2256920)
PMID:21873635
RGD PMID:2256920 PMID:19342457, PMID:11832364, PMID:21873635 RGD:727991, RGD:13792537 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in ISO (PMID:1741400), (PMID:19342457), (PMID:2256920), (PMID:23322723) RGD PMID:1741400 PMID:2256920 PMID:19342457 PMID:23322723 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scnn1b sodium channel epithelial 1 subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6478095|PMID:28567665)
Ensembl
RGD
PMID:28567665 GO_REF:0000107 MGI:6478095 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
IEA
pregnenolone
(MGI:68080|PMID:7527351)
PMID:21873635
GO_REF:0000107
(PMID:11502818), (PMID:18182448), (PMID:21636783)
RGD
Ensembl
PMID:7527351 PMID:11502818 PMID:18182448 PMID:21636783, PMID:19665544, PMID:21873635 GO_REF:0000107 MGI:68080, RGD:4891164, RGD:13792537 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:116,195,976...116,201,829 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
IBA
ISO
PMID:21873635
(PMID:2256920)
RGD PMID:2256920, PMID:11832364, PMID:21873635 RGD:727991, RGD:13792537 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in ISO (PMID:2256920) RGD PMID:2256920 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 IMP RGD PMID:9408081 RGD:1298842 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 IDA RGD PMID:1985917 RGD:632871 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:19584291)
Ensembl
RGD
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP
(PMID:19342457)
GO_REF:0000107
RGD
Ensembl
PMID:19342457, PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:16527843) RGD PMID:16527843 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA
(PMID:16981135)
GO_REF:0000107
RGD
Ensembl
PMID:16981135 GO_REF:0000107 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha IMP RGD PMID:20133449 RGD:10059648 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IDA RGD PMID:1955079 RGD:1625116
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:1703300) RGD PMID:1703300 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 acts_upstream_of_or_within ISO MGI:3042568 (MGI:3039987|PMID:14963026) RGD PMID:14963026 MGI:3039987 NCBI chr10:86,313,430...86,335,868
Ensembl chr10:86,313,383...86,335,923
JBrowse link
progesterone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 acts_upstream_of_or_within ISO MGI:3527218 (MGI:3526508|PMID:15471942) RGD PMID:15471942 MGI:3526508 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
progesterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2388722 (MGI:2388413|PMID:12297623)
Ensembl
RGD
PMID:12297623 GO_REF:0000107 MGI:2388413 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,806,095...69,827,125
Ensembl chr17:69,806,065...69,827,112
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 involved_in IBA
ISO
PMID:21873635
(PMID:21232532)
RGD PMID:21232532, PMID:21873635 RGD:13792537 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 acts_upstream_of_or_within
involved_in
IDA
IBA
ISO
PMID:8172618
PMID:21873635
(PMID:21232532)
RGD PMID:21232532, PMID:4392955, PMID:8172618, PMID:21873635 RGD:2303525, RGD:1299435, RGD:13792537 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000107
PMID:21873635
(PMID:22266943)
UniProt
Ensembl
RGD
PMID:22266943, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 IDA RGD PMID:19665544 RGD:4891164 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 involved_in ISO (PMID:10620362) RGD PMID:10620362 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 involved_in ISO (PMID:14640697) RGD PMID:14640697 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO (PMID:11294878) RGD PMID:11294878 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 IDA RGD PMID:4392955 RGD:2303525 NCBI chr 2:200,615,910...200,633,317
Ensembl chr 2:200,584,986...200,692,335
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IDA RGD PMID:9202401 RGD:4892033 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (MGI:3526508|PMID:15471942)
Ensembl
RGD
PMID:15471942 GO_REF:0000107 MGI:3526508 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO
ISS
(PMID:29403011)
GO_REF:0000024
RGD
UniProt
PMID:29403011 GO_REF:0000024 NCBI chr11:82,862,664...82,876,165
Ensembl chr11:83,883,879...83,897,394
JBrowse link
regulation of aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 acts_upstream_of_or_within ISO MGI:3050114 (MGI:3693138|PMID:17122062) RGD PMID:17122062 MGI:3693138 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:2,069,409...2,083,370
Ensembl chr14:2,069,409...2,083,370
JBrowse link
G Egr1 early growth response 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:82584|PMID:8703054)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:8703054 GO_REF:0000024 GO_REF:0000107 MGI:82584 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:23045399 RGD:26884342 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir455 microRNA 455 IDA RGD PMID:23045399 RGD:26884342 NCBI chr 5:79,097,208...79,097,285
Ensembl chr 5:79,097,208...79,097,285
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      hormone metabolic process 232
        cellular hormone metabolic process 142
          C21-steroid hormone metabolic process 44
            C21-steroid hormone biosynthetic process + 24
            C21-steroid hormone catabolic process + 1
            aldosterone metabolic process + 14
            progesterone metabolic process + 22
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13514
      regulation of biological quality 4175
        regulation of hormone levels 608
          hormone metabolic process 232
            cellular hormone metabolic process 142
              C21-steroid hormone metabolic process 44
                C21-steroid hormone biosynthetic process + 24
                C21-steroid hormone catabolic process + 1
                aldosterone metabolic process + 14
                progesterone metabolic process + 22
paths to the root