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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Spinal Cord Compression
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Accession:DOID:9001553 term browser browse the term
Definition:Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Synonyms:exact_synonym: Compressive Myelopathy;   Conus Medullaris Syndrome;   Conus Medullaris Syndromes;   Extramedullary Spinal Cord Compression;   Spinal Cord Compressions
 primary_id: MESH:D013117
 xref: EFO:1001845


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Spinal Cord Compression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 IEP mRNA, protein:increased expression, increased activity:spinal cord (rat) RGD PMID:22425718 RGD:10449098 NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687 		JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP mRNA, protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO		 mRNA, protein:increased expression:liver, serum (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15135227 PMID:15855648 RGD:11526154 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd163 CD163 molecule disease_progression IEP protein:increased expression:gray matter of spinal cord, white matter of spinal cord (rat) RGD PMID:23775900 RGD:149735576 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Chst14 carbohydrate sulfotransferase 14 exacerbates ISO RGD PMID:26586562 RGD:155663489 NCBI chr 3:105,916,481...105,918,538
Ensembl chr 3:105,916,466...105,918,548 		JBrowse link
G Egr1 early growth response 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20675054 RGD:5131876 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:9675307 RGD:10450552 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Epo erythropoietin IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO human protein in a rat model
protein:increased expression:spinal cord:		 RGD PMID:16689665 PMID:21490053 PMID:16202410 RGD:1582444, RGD:12904017, RGD:8663485 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand treatment ISO protein:increased expression:spinal cord: RGD PMID:21490053 PMID:21490053 RGD:12904017, RGD:12904017 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf2 fibroblast growth factor 2 IEP protein:increased expression:spinal cord RGD PMID:17244329 RGD:8655633 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IEP protein:increased expression:spinal cord (rat) RGD PMID:28981091 RGD:155782905 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:25595990 RGD:12437079 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 IEP protein:decreased expression:spinal cord, thoracic vertebrae (rat) RGD PMID:20399821 RGD:2326108 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:spinal cord (mouse) RGD PMID:21787762 RGD:6218959 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:cerebrospinal fluid, serum RGD PMID:30327453 RGD:14975119 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M treatment IEP RGD PMID:19457130 RGD:329902059 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:21671795 RGD:6483029 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857 		JBrowse link
G Mir17 microRNA 17 treatment IMP RGD PMID:31115018 RGD:329403058 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mt2A metallothionein 2A ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:15592854 RGD:6483848 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29323048 RGD:13504709 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135227 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:spinal cord (rat) RGD PMID:21224756 RGD:5130917 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP
ISO		 protein:increased expression:spinal cord (rat)
human protein in rat model		 RGD PMID:21224756 PMID:21224756 RGD:5130917, RGD:5130917 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    Wounds and Injuries 980
      Spinal Cord Injuries 287
        Spinal Cord Compression 26
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        central nervous system disease 12429
          spinal cord disease 1920
            Spinal Cord Injuries 287
              Spinal Cord Compression 26
paths to the root