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Heavy Metal Poisoning, Nervous System - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Heavy Metal Poisoning, Nervous System
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Accession:DOID:9001363 term browser browse the term
Definition:Conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.
Synonyms:exact_synonym: Poisoning, Heavy Metals, Nervous System
 primary_id: MESH:D020260;   RDO:0007319
 xref: EFO:1001815

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Heavy Metal Poisoning, Nervous System term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL16 interleukin 16 ISO protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861 		JBrowse link
Arsenic Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP9 A-kinase anchoring protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608 		JBrowse link
G ALAD aminolevulinate dehydratase ISO protein:decreased activity:blood (rat) RGD PMID:19022878 RGD:4144202 NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784 		JBrowse link
G AQP9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19805235 NCBI chr15:37,107,061...37,154,887
Ensembl chr15:55,418,767...55,466,541 		JBrowse link
G AS3MT arsenite methyltransferase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21447609 PMID:26366667 PMID:35226250 NCBI chr10:99,470,026...99,502,829
Ensembl chr10:102,933,671...102,964,692 		JBrowse link
G ATXN7 ataxin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:63,766,480...63,906,913
Ensembl chr 3:65,194,703...65,280,879 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CCRL2 C-C motif chemokine receptor like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:46,296,556...46,311,246
Ensembl chr 3:47,414,124...47,415,562 		JBrowse link
G CD44 CD44 molecule (IN blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009 		JBrowse link
G CD83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:13,961,342...13,980,686
Ensembl chr 6:14,330,752...14,349,946 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO protein:increased expression:skin: RGD PMID:11860939 RGD:8662429 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:22521605 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:50,152,730...50,154,974
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430 		JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr2B:32,983,492...33,020,492
Ensembl chr2B:127,922,483...127,959,372 		JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr19:1,489,263...1,491,391
Ensembl chr19:2,451,837...2,453,992 		JBrowse link
G GOLGA4 golgin A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:37,149,793...37,269,709
Ensembl chr 3:37,442,669...37,545,634 		JBrowse link
G GSR glutathione-disulfide reductase ISO RGD PMID:25209654 RGD:10401880 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G ID2 inhibitor of DNA binding 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G IER3 immediate early response 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:30,488,162...30,489,784 JBrowse link
G IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 3:182,667,557...182,848,528
Ensembl chr 3:191,142,063...191,320,221 		JBrowse link
G IL1A interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G INPP5A inositol polyphosphate-5-phosphatase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25759212 Ensembl chr10:133,437,718...133,681,116 JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129 		JBrowse link
G KRT10 keratin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19953893 NCBI chr17:16,461,624...16,466,136
Ensembl chr17:16,686,898...16,690,415 		JBrowse link
G LOC100974886 uncharacterized LOC100974886 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G LOC100992309 C-C motif chemokine 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:20,704,738...20,706,641
Ensembl chr17:21,000,709...21,002,610 		JBrowse link
G METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 4:110,879,137...110,905,131
Ensembl chr 4:121,431,026...121,458,392 		JBrowse link
G MINPP1 multiple inositol-polyphosphate phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:84,230,676...84,280,042
Ensembl chr10:87,737,649...87,787,130 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24384392 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G N4BP2L2 NEDD4 binding protein 2 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr13:13,691,326...13,803,162
Ensembl chr13:32,133,603...32,231,003 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:97,123,826...97,129,919
Ensembl chr10:100,604,914...100,611,016 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G PDE4B phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:65,038,120...65,620,764
Ensembl chr 1:67,045,911...67,506,291 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2A:64,160,362...64,213,200
Ensembl chr2A:65,284,480...65,336,339 		JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:6,185,415...6,294,641
Ensembl chr10:6,167,841...6,275,940 		JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr15:47,006,718...47,141,035
Ensembl chr15:65,276,530...65,410,105 		JBrowse link
G PNP purine nucleoside phosphorylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414634 NCBI chr14:1,343,921...1,351,670
Ensembl chr14:19,396,114...19,403,907 		JBrowse link
G PTX3 pentraxin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:154,485,470...154,492,293
Ensembl chr 3:162,537,577...162,543,652 		JBrowse link
G RFX3 regulatory factor X3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:3,024,016...3,332,266
Ensembl chr 9:3,223,405...3,398,839 		JBrowse link
G RGS1 regulator of G protein signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:168,039,235...168,043,516
Ensembl chr 1:172,333,866...172,337,401 		JBrowse link
G RNF20 ring finger protein 20 ISO protein:increased expression:urine (human) RGD PMID:21136906 RGD:9831407 NCBI chr 9:72,738,132...72,767,868
Ensembl chr 9:100,732,342...100,761,258 		JBrowse link
G RUFY3 RUN and FYVE domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:53,415,742...53,516,600
Ensembl chr 4:59,762,053...59,846,574 		JBrowse link
G SFPQ splicing factor proline and glutamine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:34,444,105...34,461,012
Ensembl chr 1:35,632,917...35,641,551 		JBrowse link
G SKIL SKI like proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:167,372,104...167,411,287
Ensembl chr 3:175,562,007...175,600,181 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G SOX18 SRY-box transcription factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338
G SRP68 signal recognition particle 68 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:69,985,207...70,019,313
Ensembl chr17:75,539,484...75,573,436 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 7:133,670,085...133,682,228
Ensembl chr 7:146,139,837...146,151,495 		JBrowse link
G TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:88,752,779...88,763,136
Ensembl chr11:92,241,126...92,250,416 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382 		JBrowse link
G TNIK TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:168,067,839...168,466,290
Ensembl chr 3:176,255,547...176,650,795 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18621066 PMID:19203779 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TRA2A transformer 2 alpha homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 7:24,184,844...24,213,889
Ensembl chr 7:23,791,479...23,820,124 		JBrowse link
G TRAPPC10 trafficking protein particle complex subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr21:30,269,085...30,363,396
Ensembl chr21:43,581,617...43,656,740 		JBrowse link
G UBE2E1 ubiquitin conjugating enzyme E2 E1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:23,719,632...23,803,302
Ensembl chr 3:24,045,747...24,127,820 		JBrowse link
G USO1 USO1 vesicle transport factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:48,391,293...48,480,909
Ensembl chr 4:54,229,601...54,317,158 		JBrowse link
G USP13 ubiquitin specific peptidase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:176,685,541...176,818,360
Ensembl chr 3:184,855,388...184,983,158 		JBrowse link
G ZFAND6 zinc finger AN1-type containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr15:59,023,678...59,107,270
Ensembl chr15:78,048,571...78,115,098 		JBrowse link
G ZNF267 zinc finger protein 267 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr16:22,924,355...22,968,670
Ensembl chr16:32,336,675...32,380,262 		JBrowse link
G ZNF331 zinc finger protein 331 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr19:50,465,659...50,524,594
Ensembl chr19:59,315,619...59,374,805 		JBrowse link
Manganese Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase ISO protein:decreased activity:striatum (rat) RGD PMID:18778733 RGD:4144152 NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22285144 NCBI chr 1:15,929,613...15,955,631
Ensembl chr 1:16,986,385...17,006,033
Ensembl chr 1:16,986,385...17,006,033 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19442826 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634 		JBrowse link
G HTT huntingtin ISO CTD Direct Evidence: therapeutic CTD PMID:19845833 NCBI chr 4:3,215,081...3,388,587
Ensembl chr 4:3,128,718...3,283,730 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:12171760 NCBI chr22:23,022,449...23,031,627 JBrowse link
G MFN2 mitofusin 2 ISO protein:decreased expression:striatum (rat) RGD PMID:28232070 RGD:12910738 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15010209 PMID:22174044 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO CTD Direct Evidence: therapeutic CTD PMID:20089134 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G SLC30A10 solute carrier family 30 member 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28860195 PMID:29429640 NCBI chr 1:195,480,707...195,528,243
Ensembl chr 1:200,522,554...200,566,228 		JBrowse link
G SLC31A1 solute carrier family 31 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22465424 NCBI chr 9:84,319,304...84,362,288
Ensembl chr 9:112,691,503...112,734,352 		JBrowse link
G SLC39A14 solute carrier family 39 member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28860195 NCBI chr 8:21,617,529...21,672,726
Ensembl chr 8:18,555,895...18,621,510 		JBrowse link
G SLC39A8 solute carrier family 39 member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29429640 NCBI chr 4:94,675,458...94,770,380
Ensembl chr 4:105,339,488...105,433,568 		JBrowse link
G SNCA synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:23934647 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Mercury Poisoning, Nervous System term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSB cathepsin B ISO RGD PMID:18638529 RGD:2315510 NCBI chr 8:7,333,498...7,359,264 JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:15515958 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G S100B S100 calcium binding protein B ISO CTD Direct Evidence: marker/mechanism CTD PMID:30076900 NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953 		JBrowse link
Nervous System Lead Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21439310 NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784 		JBrowse link
G EP300 E1A binding protein p300 ISO mRNA:increased expression:hippocampus RGD PMID:24291742 RGD:9588309 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
Nervous System Lead Poisoning, Adult term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A1 solute carrier family 6 member 1 ISO protein:increased expression:brain, synaptosome RGD PMID:15149801 RGD:1643208 NCBI chr 3:10,930,455...10,976,968
Ensembl chr 3:11,296,023...11,323,624 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15830
    syndrome 10726
      toxic encephalopathy 205
        Heavy Metal Poisoning, Nervous System 85
          Arsenic Poisoning 66
          Manganese Poisoning 16
          Mercury Poisoning, Nervous System + 3
          Nervous System Lead Poisoning + 3
Path 2
Term Annotations click to browse term
  disease 15830
    disease of anatomical entity 15487
      nervous system disease 13581
        toxic encephalopathy 205
          Heavy Metal Poisoning, Nervous System 85
            Arsenic Poisoning 66
            Manganese Poisoning 16
            Mercury Poisoning, Nervous System + 3
            Nervous System Lead Poisoning + 3
paths to the root