ID2 (inhibitor of DNA binding 2) - Rat Genome Database

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Gene: ID2 (inhibitor of DNA binding 2) Pan paniscus
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Symbol: ID2
Name: inhibitor of DNA binding 2
RGD ID: 11983278
Description: ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); adult locomotory behavior (ortholog); astrocyte differentiation (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN chromatin (ortholog); euchromatin (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-binding protein inhibitor ID-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212117,832,530 - 117,834,913 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A117,836,503 - 117,838,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A8,847,776 - 8,850,720 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
astrocyte differentiation  (ISO)
B cell differentiation  (ISO)
bundle of His development  (ISO)
cell development  (ISO)
cell differentiation  (IEA)
cell maturation  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular senescence  (ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic digestive tract morphogenesis  (ISO)
endodermal digestive tract morphogenesis  (ISO)
entrainment of circadian clock  (ISO)
entrainment of circadian clock by photoperiod  (ISO)
enucleate erythrocyte differentiation  (ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (ISO)
erythrocyte differentiation  (ISO)
heart development  (ISO)
leukocyte differentiation  (ISO)
locomotor rhythm  (ISO)
mammary gland alveolus development  (ISO)
mammary gland epithelial cell proliferation  (ISO)
membranous septum morphogenesis  (ISO)
metanephros development  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of B cell differentiation  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
Peyer's patch development  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
regulation of circadian rhythm  (ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of macromolecule metabolic process  (IEA)
regulation of neural precursor cell proliferation  (ISO)
regulation of neuron differentiation  (ISO)
regulation of nucleobase-containing compound metabolic process  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
rhythmic process  (IEA)
thigmotaxis  (ISO)
white fat cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212117,832,530 - 117,834,913 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A117,836,503 - 117,838,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A8,847,776 - 8,850,720 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensemblpanpan1.1panPan2
ID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3828,682,056 - 8,684,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl28,678,845 - 8,684,461 (+)EnsemblGRCh38hg38GRCh38
GRCh3728,822,186 - 8,824,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3628,739,564 - 8,742,034 (+)NCBINCBI36Build 36hg18NCBI36
Build 3428,772,710 - 8,775,179NCBI
Celera28,735,903 - 8,738,373 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef28,668,297 - 8,670,767 (+)NCBIHuRef
CHM1_128,751,514 - 8,753,984 (+)NCBICHM1_1
T2T-CHM13v2.028,705,779 - 8,708,184 (+)NCBIT2T-CHM13v2.0
Id2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391225,143,798 - 25,146,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1225,143,798 - 25,147,139 (-)EnsemblGRCm39 Ensembl
GRCm381225,093,799 - 25,096,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1225,093,799 - 25,097,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371225,778,664 - 25,780,957 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361225,682,879 - 25,685,148 (-)NCBIMGSCv36mm8
Celera1226,550,909 - 26,553,204 (-)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.57NCBI
Id2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,469,162 - 47,470,995 (-)NCBIGRCr8
mRatBN7.2641,740,556 - 41,742,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,728,946 - 41,744,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx642,055,220 - 42,057,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0642,370,032 - 42,371,841 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,803,153 - 41,804,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
RH 3.4 Map6240.21RGD
Cytogenetic Map6q16NCBI
Id2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487878,326 - 880,783 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487878,326 - 880,783 (-)NCBIChiLan1.0ChiLan1.0
LOC102151783
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,954,852 - 54,957,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,908,126 - 54,908,533 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,955,571 - 55,955,978 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11055,647,787 - 55,648,194 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,934,604 - 55,935,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,221,310 - 56,221,717 (+)NCBIUU_Cfam_GSD_1.0
Id2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629250,481,184 - 50,483,643 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,236,037 - 5,238,881 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,236,175 - 5,238,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3127,500,763 - 127,503,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,801,813 - 135,804,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,962,001 - 98,964,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604513,366,676 - 13,369,585 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248462,277,961 - 2,283,571 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248462,281,292 - 2,283,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034952557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000045250   ⟹   ENSPPAP00000022440
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensembl
RefSeq Acc Id: XM_034952557   ⟹   XP_034808448
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212117,832,530 - 117,834,913 (-)NCBI
NHGRI_mPanPan12A117,836,503 - 117,838,791 (-)NCBI
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034808448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000022440.1
RefSeq Acc Id: XP_034808448   ⟸   XM_034952557
- UniProtKB: A0A2R9AYZ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000022440   ⟸   ENSPPAT00000045250
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034410 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045250.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  DNA-bd_prot-inh UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene ID2 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-2 UniProtKB/TrEMBL
  PTHR11723 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A2R9AYZ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-26 ID2  inhibitor of DNA binding 2    inhibitor of DNA binding 2, HLH protein  Symbol and/or name change 5135510 APPROVED