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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cladribine
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Accession:CHEBI:567361 term browser browse the term
Definition:2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Synonyms:exact_synonym: 2-chloro-2'-deoxyadenosine
 related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;   2-CdA;   2-chloro-2'-deoxy-beta-adenosine;   2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine;   2-chloro-deoxyadenosine;   2-chlorodeoxyadenosine;   2ClAdo;   CldAdo;   Formula=C10H12ClN5O3;   InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1;   InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N;   SMILES=Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1;   cladribina;   cladribinum
 alt_id: CHEBI:31407;   CHEBI:568373
 xref: Beilstein:624220;   CAS:4291-63-8;   DrugBank:DB00242;   Drug_Central:667;   KEGG:D01370;   LINCS:LSM-5976
 xref_mesh: MESH:D017338
 xref: PMID:17526755;   PMID:18570408;   PMID:26024233;   Patent:EP173059;   Patent:US4760137;   Wikipedia:Cladribine


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cladribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]
Cladribine results in decreased expression of BCL2 protein
CTD PMID:15516989 PMID:15582267 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of BIRC3 protein] CTD PMID:12948851 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP3 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP3 protein
Cladribine results in increased activity of CASP3 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:21679466 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP6 protein]
Cladribine results in increased activity of CASP6 protein
CTD PMID:11672427 PMID:12948851 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP7 protein]
Cladribine results in increased activity of CASP7 protein
CTD PMID:12948851 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage
ISO [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]
Cladribine results in increased activity of CASP8 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:19006566 PMID:21679466 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP9 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP9 protein
Cladribine results in increased activity of CASP9 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Cladribine results in increased expression of CDKN1A mRNA
Cladribine promotes the reaction [resveratrol results in increased expression of CDKN1A mRNA]; resveratrol promotes the reaction [Cladribine results in increased expression of CDKN1A mRNA]
CTD PMID:21801466 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of DAXX protein] CTD PMID:12948851 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein] CTD PMID:12948851 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]; Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA] CTD PMID:21801466 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Il4 interleukin 4 increases expression ISO Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kmt2a lysine methyltransferase 2A increases response to substance ISO KMT2A gene mutant form results in increased susceptibility to Cladribine CTD PMID:14712291 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Lmnb1 lamin B1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein
Cladribine results in increased cleavage of LMNB1 protein
CTD PMID:15582267 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Nt5c1a 5'-nucleotidase, cytosolic IA decreases response to substance
multiple interactions
ISO NT5C1A protein results in decreased susceptibility to Cladribine
NT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]
CTD PMID:16362297 NCBI chr 5:135,473,107...135,494,400
Ensembl chr 5:135,473,231...135,499,338
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cladribine results in increased cleavage of PARP1 protein
CTD PMID:15582267 PMID:21679466 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of PAWR protein] CTD PMID:12948851 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases methylation
increases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA]; Cholecalciferol promotes the reaction [Cladribine results in increased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in decreased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in increased expression of PTEN mRNA]; resveratrol promotes the reaction [Cladribine results in decreased methylation of PTEN promoter] CTD PMID:21801466 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cladribine results in increased phosphorylation of STAT3 protein CTD PMID:21679466 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cladribine results in increased expression of TNF protein CTD PMID:10540334 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein] CTD PMID:12948851 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        immunomodulator 14893
          immunosuppressive agent 13713
            cladribine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          N-glycosyl compound 5514
                                            nucleoside 5375
                                              deoxyribonucleoside 2736
                                                2'-deoxyribonucleoside 2218
                                                  purine 2'-deoxyribonucleoside 33
                                                    cladribine 21
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