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ONTOLOGY REPORT - ANNOTATIONS


Term:cladribine
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Accession:CHEBI:567361 term browser browse the term
Definition:2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Synonyms:exact_synonym: 2-chloro-2'-deoxyadenosine
 related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;   2-CdA;   2-chloro-2'-deoxy-beta-adenosine;   2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine;   2-chloro-deoxyadenosine;   2-chlorodeoxyadenosine;   2ClAdo;   CldAdo;   Formula=C10H12ClN5O3;   InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1;   InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N;   SMILES=Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1;   cladribina;   cladribinum
 alt_id: CHEBI:31407;   CHEBI:568373
 xref: Beilstein:624220 "Beilstein";   CAS:4291-63-8 "ChemIDplus";   CAS:4291-63-8 "KEGG DRUG";   DrugBank:DB00242;   Drug_Central:667 "DrugCentral";   KEGG:D01370;   LINCS:LSM-5976
 xref_mesh: MESH:D017338
 xref: PMID:17526755 "ChEMBL";   PMID:18570408 "ChEMBL";   PMID:26024233 "Europe PMC";   Patent:EP173059;   Patent:US4760137;   Wikipedia:Cladribine


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cladribine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:6480464
G Lmnb1 lamin B1 JBrowse link 18 51,785,111 51,822,264 RGD:6480464
G Nt5c1a 5'-nucleotidase, cytosolic IA JBrowse link 5 140,888,862 140,909,322 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        immunomodulator 12650
          immunosuppressive agent 11918
            cladribine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            heteroorganic entity 19003
                              organochalcogen compound 18718
                                organooxygen compound 18629
                                  carbohydrates and carbohydrate derivatives 11703
                                    carbohydrate 11703
                                      carbohydrate derivative 11314
                                        glycosyl compound 10294
                                          N-glycosyl compound 4200
                                            nucleoside 4023
                                              deoxyribonucleoside 982
                                                2'-deoxyribonucleoside 310
                                                  purine 2'-deoxyribonucleoside 32
                                                    cladribine 21
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