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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cladribine
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Accession:CHEBI:567361 term browser browse the term
Definition:2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Synonyms:exact_synonym: 2-chloro-2'-deoxyadenosine
 related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;   2-CdA;   2-chloro-2'-deoxy-beta-adenosine;   2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine;   2-chloro-deoxyadenosine;   2-chlorodeoxyadenosine;   2ClAdo;   CldAdo;   Formula=C10H12ClN5O3;   InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1;   InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N;   SMILES=Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1;   cladribina;   cladribinum
 alt_id: CHEBI:31407;   CHEBI:568373
 xref: Beilstein:624220;   CAS:4291-63-8;   DrugBank:DB00242;   Drug_Central:667;   KEGG:D01370;   LINCS:LSM-5976
 xref_mesh: MESH:D017338
 xref: PMID:17526755;   PMID:18570408;   PMID:26024233;   Patent:EP173059;   Patent:US4760137;   Wikipedia:Cladribine


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cladribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]
Cladribine results in decreased expression of BCL2 protein
CTD PMID:15516989, PMID:15582267 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of BIRC3 protein] CTD PMID:12948851 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP3 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP3 protein
Cladribine results in increased activity of CASP3 protein
CTD PMID:11672427, PMID:12948851, PMID:15516989, PMID:21679466 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP6 protein]
Cladribine results in increased activity of CASP6 protein
CTD PMID:11672427, PMID:12948851 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP7 protein]
Cladribine results in increased activity of CASP7 protein
CTD PMID:12948851 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage
ISO [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]
Cladribine results in increased activity of CASP8 protein
CTD PMID:11672427, PMID:12948851, PMID:15516989, PMID:19006566, PMID:21679466 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP9 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP9 protein
Cladribine results in increased activity of CASP9 protein
CTD PMID:11672427, PMID:12948851, PMID:15516989 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Cladribine results in increased expression of CDKN1A mRNA
Cladribine promotes the reaction [resveratrol results in increased expression of CDKN1A mRNA]; resveratrol promotes the reaction [Cladribine results in increased expression of CDKN1A mRNA]
CTD PMID:21801466 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of DAXX protein] CTD PMID:12948851 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein] CTD PMID:12948851 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]; Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA] CTD PMID:21801466 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Il4 interleukin 4 increases expression ISO Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kmt2a lysine methyltransferase 2A increases response to substance ISO KMT2A gene mutant form results in increased susceptibility to Cladribine CTD PMID:14712291 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Lmnb1 lamin B1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein
Cladribine results in increased cleavage of LMNB1 protein
CTD PMID:15582267 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Nt5c1a 5'-nucleotidase, cytosolic IA decreases response to substance
multiple interactions
ISO NT5C1A protein results in decreased susceptibility to Cladribine
NT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]
CTD PMID:16362297 NCBI chr 5:140,888,862...140,909,322
Ensembl chr 5:140,888,973...140,904,207
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cladribine results in increased cleavage of PARP1 protein
CTD PMID:15582267, PMID:21679466 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of PAWR protein] CTD PMID:12948851 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases methylation
increases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA]; Cholecalciferol promotes the reaction [Cladribine results in increased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in decreased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in increased expression of PTEN mRNA]; resveratrol promotes the reaction [Cladribine results in decreased methylation of PTEN promoter] CTD PMID:21801466 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cladribine results in increased phosphorylation of STAT3 protein CTD PMID:21679466 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cladribine results in increased expression of TNF protein CTD PMID:10540334 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein] CTD PMID:12948851 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          immunosuppressive agent 11936
            cladribine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      carbohydrate derivative 11802
                                        glycosyl compound 10846
                                          N-glycosyl compound 5334
                                            nucleoside 5194
                                              deoxyribonucleoside 2723
                                                2'-deoxyribonucleoside 2207
                                                  purine 2'-deoxyribonucleoside 32
                                                    cladribine 21
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