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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nt5c1a
Name: 5'-nucleotidase, cytosolic IA
Acc ID: CHEBI:567361
Term: cladribine
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Chemical ID: MESH:D017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nt5c1adecreases response to substanceISONt5c1a (Mus musculus)6480464CTDNT5C1A protein results in decreased susceptibility to CladribinePMID:16362297
Nt5c1amultiple interactionsISONt5c1a (Mus musculus)6480464CTDNT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]PMID:16362297
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