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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:raspberry ketone
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Accession:CHEBI:68656 term browser browse the term
Definition:A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics.
Synonyms:exact_synonym: 4-(4-hydroxyphenyl)butan-2-one
 related_synonym: 1-(4-Hydroxyphenyl)-3-butanone;   1-(p-Hydroxyphenyl)-3-butanone;   4-(3-Oxobutyl)phenol;   4-(4-Hydroxyphenyl)-2-butanone;   4-(p-Hydroxyphenyl)-2-butanone;   4-Hydroxybenzylacetone;   Formula=C10H12O2;   InChI=1S/C10H12O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-7,12H,2-3H2,1H3;   InChIKey=NJGBTKGETPDVIK-UHFFFAOYSA-N;   SMILES=CC(=O)CCc1ccc(O)cc1;   p-Hydroxybenzyl acetone;   p-hydroxyphenylbutan-2-one
 xref: Beilstein:776080;   CAS:5471-51-2;   HMDB:HMDB0033723
 xref_mesh: MESH:C035522
 xref: MetaCyc:CPD-8647;   PMID:18321745;   PMID:18473468;   PMID:18833746;   PMID:20077243;   PMID:20226658;   PMID:20425690;   PMID:20429456;   PMID:20831962;   PMID:21702480;   PMID:21802408;   PMID:21954327;   PMID:22551412;   PMID:22890807;   PMID:5489397;   Patent:GB2470338;   Patent:US2009221694;   Patent:US2011257439;   Patent:US2012052137;   Patent:US6222062;   Patent:WO2008113495;   Patent:WO2009118755;   Patent:WO2012085287;   Reaxys:776080;   Wikipedia:Raspberry_ketone


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raspberry ketone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO raspberry ketone results in decreased expression of ACACA mRNA CTD PMID:36460224 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Apln apelin increases expression
multiple interactions		 ISO raspberry ketone results in increased expression of APLN mRNA
raspberry ketone inhibits the reaction [Dietary Fats results in increased expression of APLN mRNA]		 CTD PMID:36460224 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Ar androgen receptor multiple interactions ISO raspberry ketone binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression ISO raspberry ketone results in increased expression of CPT1C mRNA CTD PMID:36460224 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO raspberry ketone results in increased expression of DDIT3 mRNA
Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of DDIT3 mRNA]		 CTD PMID:26867644 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
multiple interactions		 ISO raspberry ketone results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]		 CTD PMID:26867644 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:37009719 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein] CTD PMID:26867644 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO raspberry ketone affects the expression of HMOX1 mRNA CTD PMID:36460224 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA] CTD PMID:37009719 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA] CTD PMID:37009719 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 raspberry ketone results in increased expression of IL6 mRNA
[Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]		 CTD PMID:36460224 PMID:37009719 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnc3 potassium voltage-gated channel subfamily C member 3 multiple interactions
increases expression		 ISO raspberry ketone inhibits the reaction [Dietary Fats results in increased expression of KCNC3 mRNA]
raspberry ketone results in increased expression of KCNC3 mRNA		 CTD PMID:36460224 NCBI chr 1:95,080,960...95,095,165
Ensembl chr 1:95,080,960...95,095,160 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]; [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein] CTD PMID:37009719 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression ISO raspberry ketone affects the expression of NFE2L2 mRNA CTD PMID:36460224 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO raspberry ketone affects the expression of NQO1 mRNA CTD PMID:36460224 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO raspberry ketone binds to and results in increased activity of OR5D18 protein CTD PMID:21142015 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO raspberry ketone results in increased expression of PNPLA2 mRNA CTD PMID:36460224 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO raspberry ketone results in increased expression of PPARA mRNA CTD PMID:36460224 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO raspberry ketone results in increased expression of PPARG mRNA CTD PMID:36460224 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:37009719 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:37009719 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 raspberry ketone results in increased expression of TNF mRNA
[Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]		 CTD PMID:36460224 PMID:37009719 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        fragrance 998
          raspberry ketone 23
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  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
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              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      methyl ketone 815
                                        raspberry ketone 23
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