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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-chloroethanol
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Accession:CHEBI:28200 term browser browse the term
Definition:A chloroethanol carrying a chloro substituent at position 2.
Synonyms:related_synonym: 2-chloroethyl alcohol;   Ethylene chlorohydrin;   Formula=C2H5ClO;   Glycol chlorohydrin;   InChI=1S/C2H5ClO/c3-1-2-4/h4H,1-2H2;   InChIKey=SZIFAVKTNFCBPC-UHFFFAOYSA-N;   SMILES=OCCCl;   beta-chloroethanol;   beta-chloroethyl alcohol
 alt_id: CHEBI:1044;   CHEBI:19507
 xref: Beilstein:878139;   CAS:107-07-3;   Gmelin:25389;   KEGG:C06753
 xref_mesh: MESH:D005023
 xref: PMID:20056735;   PMID:21266185;   PMID:767010;   PMID:7766127;   PMID:8462123;   Reaxys:878139;   UM-BBD_compID:c0005;   Wikipedia:2-Chloroethanol


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2-chloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase increases expression ISO Ethylene Chlorohydrin results in increased expression of ACLY mRNA CTD PMID:26962056 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of AKT1 protein
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein]		 CTD PMID:26962056 PMID:31499194 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Ethylene Chlorohydrin results in increased expression of BAX protein CTD PMID:31585129 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 ISO allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in decreased expression of BCL2 protein] CTD PMID:31585129 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CIDEC cell death inducing DFFA like effector c multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA] CTD PMID:31499194 NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Ethylene Chlorohydrin results in increased expression of CPT1A mRNA CTD PMID:26962056 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression
multiple interactions		 ISO Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA; Ethylene Chlorohydrin results in increased expression of CYP2E1 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]		 CTD PMID:31585129 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G FGF21 fibroblast growth factor 21 multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression		 ISO allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein]
Ethylene Chlorohydrin results in increased expression of GCLC mRNA; Ethylene Chlorohydrin results in increased expression of GCLC protein		 CTD PMID:31585129 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GLUL glutamate-ammonia ligase decreases expression
multiple interactions		 ISO Ethylene Chlorohydrin results in decreased expression of GLUL mRNA
Ethylene Chlorohydrin results in decreased expression of and results in decreased activity of GLUL protein		 CTD PMID:27596522 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]] CTD PMID:31499194 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases expression ISO Ethylene Chlorohydrin results in increased expression of GSK3B mRNA CTD PMID:26962056 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 ISO Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA; Ethylene Chlorohydrin results in increased expression of HMOX1 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]		 CTD PMID:31585129 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:26962056 PMID:31499194 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:31585129 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:31585129 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MTOR mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of MTOR protein
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein]		 CTD PMID:26962056 PMID:31499194 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein]
Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA; Ethylene Chlorohydrin results in increased expression of NFE2L2 protein		 CTD PMID:31585129 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Ethylene Chlorohydrin results in increased expression of PCK1 mRNA CTD PMID:26962056 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA] CTD PMID:31499194 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]] CTD PMID:31499194 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPINE2 serpin family E member 2 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA] CTD PMID:26962056 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 decreases expression ISO Ethylene Chlorohydrin results in decreased expression of SLC1A2 protein CTD PMID:27596522 NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063 		JBrowse link
G SLC1A3 solute carrier family 1 member 3 decreases expression ISO Ethylene Chlorohydrin results in decreased expression of SLC1A3 mRNA; Ethylene Chlorohydrin results in decreased expression of SLC1A3 protein CTD PMID:27596522 NCBI chr 5:36,606,606...36,688,334
Ensembl chr 5:36,596,588...36,688,334 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression ISO Ethylene Chlorohydrin results in increased expression of SLC2A4 mRNA CTD PMID:26962056 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SP1 Sp1 transcription factor increases expression
multiple interactions		 ISO Ethylene Chlorohydrin results in increased expression of SP1 mRNA
Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA]		 CTD PMID:31585129 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein] CTD PMID:31499194 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA CTD PMID:31499194 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO Ethylene Chlorohydrin inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] CTD PMID:26962056 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          metabolite 25098
            xenobiotic metabolite 16958
              2-chloroethanol 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      chalcogen 24922
                        oxygen atom 24811
                          oxygen molecular entity 24811
                            hydroxides 24053
                              organic hydroxy compound 22062
                                alcohol 16629
                                  primary alcohol 15339
                                    ethanols 9065
                                      chloroethanol 45
                                        2-chloroethanol 32
paths to the root