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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloroethanol
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Accession:CHEBI:23141 term browser browse the term
Definition:An organochlorine compound that is ethanol substituted by at least one chloro group.
Synonyms:related_synonym: chloroethanols

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2,2,2-trichloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding ISO 2,2,2-trichloroethanol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 2,2,2-trichloroethanol results in increased expression of IL1A protein CTD PMID:23041168 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO 2,2,2-trichloroethanol results in increased expression of IL6 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein]		 CTD PMID:23041168 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity		 ISO 2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein
2,2,2-trichloroethanol results in increased activity of MMP9 protein		 CTD PMID:21741468 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein CTD PMID:21741468 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
2-chloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO Ethylene Chlorohydrin results in increased expression of ACLY mRNA CTD PMID:26962056 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of AKT1 protein
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein]		 CTD PMID:26962056 PMID:31499194 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Ethylene Chlorohydrin results in increased expression of BAX protein CTD PMID:31585129 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Ethylene Chlorohydrin results in decreased expression of BCL2 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in decreased expression of BCL2 protein]		 CTD PMID:31585129 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA] CTD PMID:31499194 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Ethylene Chlorohydrin results in increased expression of CPT1A mRNA CTD PMID:26962056 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]
Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA; Ethylene Chlorohydrin results in increased expression of CYP2E1 protein		 CTD PMID:31585129 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 EXP allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein]
Ethylene Chlorohydrin results in increased expression of GCLC mRNA; Ethylene Chlorohydrin results in increased expression of GCLC protein		 CTD PMID:31585129 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression
multiple interactions		 EXP Ethylene Chlorohydrin results in decreased expression of GLUL mRNA
Ethylene Chlorohydrin results in decreased expression of and results in decreased activity of GLUL protein		 CTD PMID:27596522 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]] CTD PMID:31499194 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO Ethylene Chlorohydrin results in increased expression of GSK3B mRNA CTD PMID:26962056 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA; Ethylene Chlorohydrin results in increased expression of HMOX1 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]		 CTD PMID:31585129 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:26962056 PMID:31499194 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:31585129 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein] CTD PMID:31585129 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 ISO Ethylene Chlorohydrin results in increased phosphorylation of MTOR protein
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein]		 CTD PMID:26962056 PMID:31499194 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression		 EXP allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein]
Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA; Ethylene Chlorohydrin results in increased expression of NFE2L2 protein		 CTD PMID:31585129 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:26962056 PMID:31499194 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Ethylene Chlorohydrin results in increased expression of PCK1 mRNA CTD PMID:26962056 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA] CTD PMID:31499194 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]] CTD PMID:31499194 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA] CTD PMID:26962056 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression EXP Ethylene Chlorohydrin results in decreased expression of SLC1A2 protein CTD PMID:27596522 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 decreases expression EXP Ethylene Chlorohydrin results in decreased expression of SLC1A3 mRNA; Ethylene Chlorohydrin results in decreased expression of SLC1A3 protein CTD PMID:27596522 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Ethylene Chlorohydrin results in increased expression of SLC2A4 mRNA CTD PMID:26962056 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression		 EXP Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA] CTD PMID:31585129 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein] CTD PMID:31499194 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA CTD PMID:31499194 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Ethylene Chlorohydrin inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] CTD PMID:26962056 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        polyatomic entity 19740
          heteroatomic molecular entity 19682
            halide 18142
              organohalogen compound 17920
                organochlorine compound 17731
                  chloroethanol 36
                    2,2,2-trichloroethanol 5
                    2-chloroethanol 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              organic hydroxy compound 18672
                                alcohol 15086
                                  primary alcohol 14007
                                    ethanols 8182
                                      chloroethanol 36
                                        2,2,2-trichloroethanol 5
                                        2-chloroethanol 32
paths to the root