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G |
Esr2 |
estrogen receptor 2 |
affects binding |
ISO |
2,2,2-trichloroethanol binds to ESR2 protein |
CTD |
PMID:12224631 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
2,2,2-trichloroethanol results in increased expression of IL1A protein |
CTD |
PMID:23041168 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
2,2,2-trichloroethanol results in increased expression of IL6 protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein] |
CTD |
PMID:23041168 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression increases activity |
ISO |
2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein 2,2,2-trichloroethanol results in increased activity of MMP9 protein |
CTD |
PMID:21741468 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein |
CTD |
PMID:21741468 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Acly |
ATP citrate lyase |
increases expression |
ISO |
Ethylene Chlorohydrin results in increased expression of ACLY mRNA |
CTD |
PMID:26962056 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Ethylene Chlorohydrin results in increased phosphorylation of AKT1 protein [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Ethylene Chlorohydrin results in increased expression of BAX protein |
CTD |
PMID:31585129 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP |
Ethylene Chlorohydrin results in decreased expression of BCL2 protein allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in decreased expression of BCL2 protein] |
CTD |
PMID:31585129 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Cidec |
cell death-inducing DFFA-like effector c |
multiple interactions |
ISO |
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA] |
CTD |
PMID:31499194 |
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NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Ethylene Chlorohydrin results in increased expression of CPT1A mRNA |
CTD |
PMID:26962056 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
EXP |
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein] Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA; Ethylene Chlorohydrin results in increased expression of CYP2E1 protein |
CTD |
PMID:31585129 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] |
CTD |
PMID:31499194 |
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NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
EXP |
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein] Ethylene Chlorohydrin results in increased expression of GCLC mRNA; Ethylene Chlorohydrin results in increased expression of GCLC protein |
CTD |
PMID:31585129 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Glul |
glutamate-ammonia ligase |
decreases expression multiple interactions |
EXP |
Ethylene Chlorohydrin results in decreased expression of GLUL mRNA Ethylene Chlorohydrin results in decreased expression of and results in decreased activity of GLUL protein |
CTD |
PMID:27596522 |
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NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]] |
CTD |
PMID:31499194 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases expression |
ISO |
Ethylene Chlorohydrin results in increased expression of GSK3B mRNA |
CTD |
PMID:26962056 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA; Ethylene Chlorohydrin results in increased expression of HMOX1 protein allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein] |
CTD |
PMID:31585129 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:31585129 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP |
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:31585129 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation multiple interactions |
ISO |
Ethylene Chlorohydrin results in increased phosphorylation of MTOR protein [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
EXP |
allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of NFE2L2 protein] Ethylene Chlorohydrin results in increased expression of NFE2L2 mRNA; Ethylene Chlorohydrin results in increased expression of NFE2L2 protein |
CTD |
PMID:31585129 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] |
CTD |
PMID:26962056 PMID:31499194 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
ISO |
Ethylene Chlorohydrin results in increased expression of PCK1 mRNA |
CTD |
PMID:26962056 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA] |
CTD |
PMID:31499194 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]] |
CTD |
PMID:31499194 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Serpine2 |
serpin family E member 2 |
multiple interactions |
ISO |
Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA] |
CTD |
PMID:26962056 |
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NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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G |
Slc1a2 |
solute carrier family 1 member 2 |
decreases expression |
EXP |
Ethylene Chlorohydrin results in decreased expression of SLC1A2 protein |
CTD |
PMID:27596522 |
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NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc1a3 |
solute carrier family 1 member 3 |
decreases expression |
EXP |
Ethylene Chlorohydrin results in decreased expression of SLC1A3 mRNA; Ethylene Chlorohydrin results in decreased expression of SLC1A3 protein |
CTD |
PMID:27596522 |
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NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
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G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
ISO |
Ethylene Chlorohydrin results in increased expression of SLC2A4 mRNA |
CTD |
PMID:26962056 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions increases expression |
EXP |
Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA] |
CTD |
PMID:31585129 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein] |
CTD |
PMID:31499194 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA |
CTD |
PMID:31499194 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Ethylene Chlorohydrin inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] |
CTD |
PMID:26962056 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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