FGF21 (fibroblast growth factor 21) - Rat Genome Database

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Gene: FGF21 (fibroblast growth factor 21) Homo sapiens
Analyze
Symbol: FGF21
Name: fibroblast growth factor 21
RGD ID: 1344631
HGNC Page HGNC:3678
Description: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of D-glucose import and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of atherosclerosis; chronic kidney disease; and steatotic liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FGF-21
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,755,524 - 48,758,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,755,524 - 48,758,333 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,258,781 - 49,261,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,951,156 - 53,953,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,951,305 - 53,953,289NCBI
Celera1946,125,436 - 46,127,638 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,638,191 - 45,640,357 (+)NCBIHuRef
CHM1_11949,261,115 - 49,263,353 (+)NCBICHM1_1
T2T-CHM13v2.01951,749,989 - 51,752,722 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,4-dithiothreitol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-chloroethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bromobenzene  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP,ISO)
cobalt dichloride  (EXP)
corn oil  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
dioxygen  (EXP)
diquat  (ISO)
endosulfan  (ISO)
epalrestat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
famotidine  (EXP)
fenofibrate  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
GSK2656157  (ISO)
GW 4064  (ISO)
GW 7647  (EXP)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (EXP)
imidazopyrazole  (EXP)
indole-3-methanol  (ISO)
inulin  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamine  (ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
Octicizer  (ISO)
oleic acid  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
vanillic acid  (EXP)
very-low-density lipoprotein triglyceride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk. Al-Aqil FA, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2927-2937. doi: 10.1016/j.bbadis.2018.06.003. Epub 2018 Jun 6.
2. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? Arafat AM, etal., Diabetologia. 2013 Mar;56(3):588-97. doi: 10.1007/s00125-012-2803-y. Epub 2012 Dec 22.
3. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Chow WS, etal., Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2454-9. doi: 10.1161/ATVBAHA.113.301599. Epub 2013 Jul 25.
4. Serum fibroblast growth factor 21 is associated with renal function and chronic kidney disease in community-dwelling adults. Crasto C, etal., J Am Geriatr Soc. 2012 Apr;60(4):792-3. doi: 10.1111/j.1532-5415.2011.03879.x.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. Hu Y, etal., JHEP Rep. 2020 Feb 18;2(2):100093. doi: 10.1016/j.jhepr.2020.100093. eCollection 2020 Apr.
7. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Johnson CL, etal., Gastroenterology. 2009 Nov;137(5):1795-804. doi: 10.1053/j.gastro.2009.07.064. Epub 2009 Aug 5.
8. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Kamimura N, etal., Obesity (Silver Spring). 2011 Jul;19(7):1396-403. doi: 10.1038/oby.2011.6. Epub 2011 Feb 3.
9. Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function. Kim JH, etal., Diabetes Obes Metab. 2015 Feb;17(2):161-9. doi: 10.1111/dom.12408. Epub 2014 Nov 28.
10. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. Lee CH, etal., J Clin Endocrinol Metab. 2015 Apr;100(4):1368-75. doi: 10.1210/jc.2014-3465. Epub 2015 Jan 27.
11. FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. Leng Y, etal., Mol Psychiatry. 2015 Feb;20(2):215-23. doi: 10.1038/mp.2013.192. Epub 2014 Jan 28.
12. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Nishimura T, etal., Biochim Biophys Acta 2000 Jun 21;1492(1):203-6.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Planavila A, etal., Nat Commun. 2013;4:2019. doi: 10.1038/ncomms3019.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats. Wang WF, etal., Endocrine. 2015 May;49(1):119-29. doi: 10.1007/s12020-014-0433-5. Epub 2014 Oct 12.
17. Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Xiao Y, etal., Cardiovasc Diabetol. 2015 Jun 6;14:72. doi: 10.1186/s12933-015-0229-9.
Additional References at PubMed
PMID:12477932   PMID:12975309   PMID:15199049   PMID:15340161   PMID:15902306   PMID:17068132   PMID:17452648   PMID:17623664   PMID:17926232   PMID:18252893   PMID:18559909   PMID:18680716  
PMID:18722685   PMID:18829467   PMID:18840768   PMID:19059246   PMID:19117008   PMID:19318452   PMID:19322201   PMID:19401423   PMID:19487637   PMID:19528204   PMID:19531592   PMID:19681655  
PMID:19699495   PMID:19702724   PMID:19720803   PMID:19926712   PMID:19953087   PMID:20332535   PMID:20362303   PMID:20451522   PMID:20452080   PMID:20566462   PMID:20566587   PMID:20629328  
PMID:20675007   PMID:20682689   PMID:20717167   PMID:21060863   PMID:21123446   PMID:21206918   PMID:21309058   PMID:21373720   PMID:21502324   PMID:21505329   PMID:21521346   PMID:21521350  
PMID:21525989   PMID:21596453   PMID:21664250   PMID:21691104   PMID:21696361   PMID:21712364   PMID:21750278   PMID:21767451   PMID:21812521   PMID:21820356   PMID:21849508   PMID:21873635  
PMID:21889884   PMID:21926274   PMID:21926972   PMID:21949781   PMID:21988350   PMID:21988832   PMID:22013098   PMID:22046277   PMID:22136913   PMID:22152380   PMID:22190000   PMID:22233381  
PMID:22248288   PMID:22293928   PMID:22302939   PMID:22344195   PMID:22378787   PMID:22398021   PMID:22438225   PMID:22442730   PMID:22523080   PMID:22529197   PMID:22539584   PMID:22701542  
PMID:22740503   PMID:22881230   PMID:23123503   PMID:23129782   PMID:23270727   PMID:23278761   PMID:23283977   PMID:23372041   PMID:23533568   PMID:23545215   PMID:23626003   PMID:23636237  
PMID:23667629   PMID:23736373   PMID:23759753   PMID:23768789   PMID:23782039   PMID:23824729   PMID:23840612   PMID:23912560   PMID:23943793   PMID:23981342   PMID:24078096   PMID:24142477  
PMID:24184811   PMID:24205333   PMID:24260557   PMID:24369918   PMID:24397811   PMID:24432989   PMID:24506871   PMID:24612017   PMID:24700140   PMID:24724557   PMID:24733293   PMID:24735204  
PMID:24769090   PMID:24813368   PMID:24841294   PMID:24848261   PMID:24895044   PMID:24895642   PMID:24907231   PMID:25013999   PMID:25039824   PMID:25055037   PMID:25137423   PMID:25170079  
PMID:25170746   PMID:25194937   PMID:25300595   PMID:25359230   PMID:25365322   PMID:25411238   PMID:25495872   PMID:25538153   PMID:25549692   PMID:25604041   PMID:25659979   PMID:25664662  
PMID:25675147   PMID:25722462   PMID:25766411   PMID:25781694   PMID:25814554   PMID:25843656   PMID:25850006   PMID:25868802   PMID:25929297   PMID:25985218   PMID:26055067   PMID:26068142  
PMID:26091256   PMID:26092866   PMID:26241324   PMID:26274346   PMID:26294388   PMID:26329882   PMID:26338887   PMID:26456333   PMID:26529252   PMID:26567701   PMID:26797127   PMID:26823820  
PMID:26867126   PMID:26872317   PMID:26884286   PMID:26887040   PMID:26915669   PMID:26950284   PMID:26962859   PMID:26982498   PMID:27003131   PMID:27010621   PMID:27061435   PMID:27106505  
PMID:27118870   PMID:27164684   PMID:27179139   PMID:27179781   PMID:27184848   PMID:27226639   PMID:27285327   PMID:27305706   PMID:27318658   PMID:27453549   PMID:27482056   PMID:27505721  
PMID:27548521   PMID:27581055   PMID:27583468   PMID:27593966   PMID:27611701   PMID:27650781   PMID:27794108   PMID:27794110   PMID:27832059   PMID:27916484   PMID:28005535   PMID:28039838  
PMID:28078804   PMID:28106545   PMID:28123933   PMID:28123934   PMID:28139438   PMID:28225059   PMID:28326329   PMID:28359360   PMID:28422956   PMID:28467924   PMID:28582462   PMID:28588089  
PMID:28588304   PMID:28591702   PMID:28698650   PMID:28735064   PMID:28759185   PMID:28820393   PMID:28821258   PMID:28825598   PMID:28887067   PMID:28938434   PMID:28965199   PMID:29031905  
PMID:29077838   PMID:29107287   PMID:29107295   PMID:29299795   PMID:29342135   PMID:29351855   PMID:29367522   PMID:29410351   PMID:29427162   PMID:29436198   PMID:29462798   PMID:29476704  
PMID:29528583   PMID:29581470   PMID:29608670   PMID:29657029   PMID:29754168   PMID:29768065   PMID:29771383   PMID:29953859   PMID:30019838   PMID:30043445   PMID:30089729   PMID:30185439  
PMID:30198244   PMID:30228048   PMID:30298107   PMID:30307155   PMID:30317562   PMID:30334297   PMID:30346647   PMID:30446181   PMID:30484680   PMID:30578395   PMID:30641825   PMID:30688648  
PMID:30888221   PMID:30926667   PMID:31152776   PMID:31178962   PMID:31205953   PMID:31241504   PMID:31255518   PMID:31289229   PMID:31323006   PMID:31372821   PMID:31413360   PMID:31455871  
PMID:31523008   PMID:31672443   PMID:31686543   PMID:31798902   PMID:31817052   PMID:31915301   PMID:31977105   PMID:31997152   PMID:32066255   PMID:32101022   PMID:32167928   PMID:32188054  
PMID:32210348   PMID:32220662   PMID:32267096   PMID:32267352   PMID:32296183   PMID:32431189   PMID:32469231   PMID:32504279   PMID:32513031   PMID:32546231   PMID:32602078   PMID:32684151  
PMID:32756564   PMID:32814053   PMID:32857451   PMID:32911033   PMID:32929325   PMID:32979381   PMID:33071964   PMID:33097385   PMID:33125701   PMID:33131010   PMID:33132219   PMID:33162410  
PMID:33264784   PMID:33310036   PMID:33330965   PMID:33353469   PMID:33373666   PMID:33383173   PMID:33387664   PMID:33436812   PMID:33571698   PMID:33588820   PMID:33617873   PMID:33670024  
PMID:33713667   PMID:33753729   PMID:33770382   PMID:33789910   PMID:33810243   PMID:33849110   PMID:33907846   PMID:33924457   PMID:33946944   PMID:33995273   PMID:34019585   PMID:34086518  
PMID:34167789   PMID:34203775   PMID:34321008   PMID:34360670   PMID:34379890   PMID:34405516   PMID:34419687   PMID:34476847   PMID:34572118   PMID:34591968   PMID:34592531   PMID:34690353  
PMID:34812573   PMID:34836209   PMID:34865514   PMID:34907727   PMID:34912302   PMID:34918690   PMID:34939977   PMID:34972147   PMID:34989130   PMID:35017468   PMID:35069790   PMID:35111398  
PMID:35172300   PMID:35183545   PMID:35242298   PMID:35277004   PMID:35282437   PMID:35334074   PMID:35380342   PMID:35385705   PMID:35410857   PMID:35491674   PMID:35620925   PMID:35630668  
PMID:35745238   PMID:35883694   PMID:35909513   PMID:35993214   PMID:36075510   PMID:36134579   PMID:36174877   PMID:36180826   PMID:36208799   PMID:36213282   PMID:36220813   PMID:36263162  
PMID:36270508   PMID:36372296   PMID:36474191   PMID:36501091   PMID:36602629   PMID:36629821   PMID:36808549   PMID:36931558   PMID:37108444   PMID:37242268   PMID:37246726   PMID:37251684  
PMID:37374349   PMID:37386374   PMID:37549445   PMID:37576954   PMID:37649397   PMID:37660729   PMID:37728457   PMID:37739649   PMID:37746951   PMID:37864659   PMID:37910178   PMID:38057786  
PMID:38180987   PMID:38216702   PMID:38247441   PMID:38271099   PMID:38309558   PMID:38312833   PMID:38390325   PMID:38459267   PMID:38508095   PMID:38554044   PMID:38732501   PMID:38789571  
PMID:38851619   PMID:38894596   PMID:38910123   PMID:38959886   PMID:38991938   PMID:39226764   PMID:39341924  


Genomics

Comparative Map Data
FGF21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,755,524 - 48,758,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,755,524 - 48,758,333 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,258,781 - 49,261,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,951,156 - 53,953,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,951,305 - 53,953,289NCBI
Celera1946,125,436 - 46,127,638 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,638,191 - 45,640,357 (+)NCBIHuRef
CHM1_11949,261,115 - 49,263,353 (+)NCBICHM1_1
T2T-CHM13v2.01951,749,989 - 51,752,722 (+)NCBIT2T-CHM13v2.0
Fgf21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,263,314 - 45,264,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,263,310 - 45,264,914 (-)EnsemblGRCm39 Ensembl
GRCm38745,613,890 - 45,615,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,613,886 - 45,615,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,869,260 - 52,870,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36735,187,750 - 35,189,350 (-)NCBIMGSCv36mm8
MGSCv36745,481,932 - 45,483,532 (-)NCBIMGSCv36mm8
Celera741,070,177 - 41,081,186 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.38NCBI
Fgf21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,219,825 - 105,221,376 (-)NCBIGRCr8
mRatBN7.2196,083,360 - 96,084,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,083,441 - 96,090,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,468,930 - 101,470,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,941,627 - 109,942,870 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,232,004 - 103,233,247 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,595,579 - 101,596,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,595,579 - 101,596,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,674,359 - 102,675,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,082,475 - 96,083,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,160,585 - 96,161,829 (-)NCBI
Celera190,337,152 - 90,338,395 (-)NCBICelera
Cytogenetic Map1q22NCBI
Fgf21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,817,110 - 1,820,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,818,400 - 1,821,423 (-)NCBIChiLan1.0ChiLan1.0
FGF21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,858,680 - 54,863,094 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,785,023 - 56,789,078 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,755,466 - 45,758,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,345,966 - 54,347,712 (+)NCBIpanpan1.1PanPan1.1panPan2
FGF21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,571,449 - 107,576,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,571,446 - 107,573,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,093,881 - 107,096,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,096,091 - 108,098,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,096,198 - 108,097,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,762,951 - 107,765,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,409,841 - 107,412,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,245,446 - 108,247,884 (-)NCBIUU_Cfam_GSD_1.0
Fgf21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,208,545 - 21,210,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,826,823 - 2,828,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,826,823 - 2,828,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,080,739 - 54,084,601 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,082,653 - 54,084,532 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,828,972 - 49,831,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,006,125 - 42,008,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,006,064 - 42,008,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,876,517 - 21,879,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,164,856 - 5,167,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,165,195 - 5,166,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF21
30 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33(chr19:48577651-48839042)x3 copy number gain See cases [RCV000135686] Chr19:48577651..48839042 [GRCh38]
Chr19:49080908..49342299 [GRCh37]
Chr19:53772720..54034111 [NCBI36]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19q13.33(chr19:49169554-49388064)x3 copy number gain not provided [RCV000684074] Chr19:49169554..49388064 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.33(chr19:49260273-49334248)x3 copy number gain not provided [RCV000740201] Chr19:49260273..49334248 [GRCh37]
Chr19:19q13.33
benign
NM_019113.4(FGF21):c.12C>T (p.Asp4=) single nucleotide variant not provided [RCV000903622] Chr19:48756248 [GRCh38]
Chr19:49259505 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
NM_019113.4(FGF21):c.444G>T (p.Gly148=) single nucleotide variant not provided [RCV000920734] Chr19:48758034 [GRCh38]
Chr19:49261291 [GRCh37]
Chr19:19q13.33
likely benign
NM_019113.4(FGF21):c.9G>A (p.Ser3=) single nucleotide variant not provided [RCV000918437] Chr19:48756245 [GRCh38]
Chr19:49259502 [GRCh37]
Chr19:19q13.33
likely benign
NM_019113.4(FGF21):c.303C>G (p.Phe101Leu) single nucleotide variant not specified [RCV004287847] Chr19:48756993 [GRCh38]
Chr19:49260250 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.621C>T (p.Tyr207=) single nucleotide variant not provided [RCV000961666] Chr19:48758211 [GRCh38]
Chr19:49261468 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic
GRCh37/hg19 19q13.33(chr19:48854319-49430535)x3 copy number gain not provided [RCV001259943] Chr19:48854319..49430535 [GRCh37]
Chr19:19q13.33
likely pathogenic
NC_000019.9:g.(?_48618906)_(50921204_?)dup duplication Developmental and epileptic encephalopathy, 12 [RCV001939968]|not provided [RCV001916178] Chr19:48618906..50921204 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.584G>A (p.Ser195Asn) single nucleotide variant not specified [RCV004142169] Chr19:48758174 [GRCh38]
Chr19:49261431 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.545C>T (p.Ala182Val) single nucleotide variant not specified [RCV004142765] Chr19:48758135 [GRCh38]
Chr19:49261392 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.508C>G (p.Leu170Val) single nucleotide variant not specified [RCV004193308] Chr19:48758098 [GRCh38]
Chr19:49261355 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.487C>T (p.Arg163Cys) single nucleotide variant not specified [RCV004116143] Chr19:48758077 [GRCh38]
Chr19:49261334 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.263C>T (p.Pro88Leu) single nucleotide variant not specified [RCV004238302] Chr19:48756953 [GRCh38]
Chr19:49260210 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.371G>A (p.Arg124Gln) single nucleotide variant not specified [RCV004193003] Chr19:48757961 [GRCh38]
Chr19:49261218 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.196G>A (p.Asp66Asn) single nucleotide variant not specified [RCV004162776] Chr19:48756432 [GRCh38]
Chr19:49259689 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.517G>C (p.Ala173Pro) single nucleotide variant not specified [RCV004138285] Chr19:48758107 [GRCh38]
Chr19:49261364 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.214G>A (p.Ala72Thr) single nucleotide variant not specified [RCV004072189] Chr19:48756450 [GRCh38]
Chr19:49259707 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.424C>G (p.Leu142Val) single nucleotide variant not specified [RCV004198186] Chr19:48758014 [GRCh38]
Chr19:49261271 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.464A>T (p.Asp155Val) single nucleotide variant not specified [RCV004157745] Chr19:48758054 [GRCh38]
Chr19:49261311 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.277A>G (p.Ile93Val) single nucleotide variant not specified [RCV004167606] Chr19:48756967 [GRCh38]
Chr19:49260224 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.338C>G (p.Ser113Trp) single nucleotide variant not specified [RCV004081097] Chr19:48757028 [GRCh38]
Chr19:49260285 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.185A>C (p.Glu62Ala) single nucleotide variant not specified [RCV004340047] Chr19:48756421 [GRCh38]
Chr19:49259678 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.512C>A (p.Pro171His) single nucleotide variant not specified [RCV004353596] Chr19:48758102 [GRCh38]
Chr19:49261359 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.608G>A (p.Arg203Gln) single nucleotide variant not specified [RCV004339819] Chr19:48758198 [GRCh38]
Chr19:49261455 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.133C>T (p.Arg45Trp) single nucleotide variant Congenital fibrosis of extraocular muscles [RCV003883432] Chr19:48756369 [GRCh38]
Chr19:49259626 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q13.33-13.41(chr19:48905537-51614930)x3 copy number gain not specified [RCV003986127] Chr19:48905537..51614930 [GRCh37]
Chr19:19q13.33-13.41
likely pathogenic
NM_019113.4(FGF21):c.139C>T (p.Arg47Trp) single nucleotide variant not specified [RCV004394056] Chr19:48756375 [GRCh38]
Chr19:49259632 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.472C>G (p.Pro158Ala) single nucleotide variant not specified [RCV004394060] Chr19:48758062 [GRCh38]
Chr19:49261319 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.145C>A (p.Leu49Ile) single nucleotide variant not specified [RCV004394057] Chr19:48756381 [GRCh38]
Chr19:49259638 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.394T>C (p.Tyr132His) single nucleotide variant not specified [RCV004394059] Chr19:48757984 [GRCh38]
Chr19:49261241 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.314G>A (p.Arg105Gln) single nucleotide variant not specified [RCV004394058] Chr19:48757004 [GRCh38]
Chr19:49260261 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.460C>T (p.Arg154Trp) single nucleotide variant not specified [RCV004623268] Chr19:48758050 [GRCh38]
Chr19:49261307 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_019113.4(FGF21):c.572C>T (p.Ser191Leu) single nucleotide variant not specified [RCV004623269] Chr19:48758162 [GRCh38]
Chr19:49261419 [GRCh37]
Chr19:19q13.33
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:102
Interacting mature miRNAs:106
Transcripts:ENST00000222157, ENST00000593756
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407009862GWAS658838_Hprotein intake measurement QTL GWAS658838 (human)4e-26eating behavior trait (VT:0001431)194875627248756273Human
406946889GWAS595865_Henergy intake QTL GWAS595865 (human)8e-09energy intake194875627248756273Human
407117900GWAS766876_Htriglycerides in very large HDL measurement QTL GWAS766876 (human)4e-14triglycerides in very large HDL measurement 194875811148758112Human
407009867GWAS658843_Hcarbohydrate intake measurement QTL GWAS658843 (human)7e-15eating behavior trait (VT:0001431)194875627248756273Human
407129039GWAS778015_Htriglyceride:HDL cholesterol ratio QTL GWAS778015 (human)5e-15triglyceride:HDL cholesterol ratio194875627248756273Human
407010124GWAS659100_Htriglyceride measurement QTL GWAS659100 (human)8e-13taste liking measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407036237GWAS685213_Hfatty acid measurement QTL GWAS685213 (human)1e-16fatty acid measurement194875627248756273Human
406934481GWAS583457_Henergy intake QTL GWAS583457 (human)9e-23energy intake194875627248756273Human
406934483GWAS583459_Henergy intake QTL GWAS583459 (human)5e-28energy intake194875627248756273Human
407023185GWAS672161_Hhomocysteine measurement QTL GWAS672161 (human)7e-09homocysteine measurement194875627248756273Human
407280213GWAS929189_Htaste liking measurement QTL GWAS929189 (human)2e-11taste liking measurement194875627248756273Human
406934482GWAS583458_Henergy intake QTL GWAS583458 (human)1e-19energy intake194875627248756273Human
407064534GWAS713510_Hcathepsin D measurement QTL GWAS713510 (human)9e-12cathepsin D measurement194875627248756273Human
407238992GWAS887968_Htriglyceride measurement, intermediate density lipoprotein measurement QTL GWAS887968 (human)5e-15triglyceride measurement, intermediate density lipoprotein measurementblood intermediate density lipoprotein cholesterol level (CMO:0001562)194875811148758112Human
407108186GWAS757162_Halcohol consumption measurement QTL GWAS757162 (human)8e-48alcohol consumption measurementethanol drink intake rate (CMO:0001407)194875627248756273Human
406919389GWAS568365_Htriglyceride measurement QTL GWAS568365 (human)9e-18triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407381352GWAS1030328_Hdiet measurement QTL GWAS1030328 (human)5e-09diet measurementfood intake measurement (CMO:0000772)194875606448756065Human
406921963GWAS570939_Htriglyceride measurement QTL GWAS570939 (human)2e-33triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407280748GWAS929724_Htaste liking measurement QTL GWAS929724 (human)3e-10taste liking measurement194875659748756598Human
407187817GWAS836793_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS836793 (human)2e-12fatty acid measurementblood low density lipoprotein cholesterol level (CMO:0000053)194875811148758112Human
407280115GWAS929091_Htaste liking measurement QTL GWAS929091 (human)3e-09taste liking measurement194875627248756273Human
407282943GWAS931919_Htaste liking measurement QTL GWAS931919 (human)1e-10taste liking measurement194875627248756273Human
407282431GWAS931407_Htaste liking measurement QTL GWAS931407 (human)9e-11taste liking measurement194875627248756273Human
407284348GWAS933324_Htaste liking measurement QTL GWAS933324 (human)7e-10taste liking measurement194875627248756273Human
407313285GWAS962261_Hfat intake measurement QTL GWAS962261 (human)6e-23eating behavior trait (VT:0001431)194875627248756273Human
407346180GWAS995156_Htriglyceride measurement QTL GWAS995156 (human)4e-21triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407132800GWAS781776_Htriglyceride:HDL cholesterol ratio QTL GWAS781776 (human)1e-11taste liking measurement194875627248756273Human
407260291GWAS909267_Htaste liking measurement QTL GWAS909267 (human)1e-36taste liking measurement194875627248756273Human
407008772GWAS657748_Hsugar consumption measurement QTL GWAS657748 (human)3e-20sugar consumption measurementsucrose drink intake volume (CMO:0002200)194875627248756273Human
407256577GWAS905553_Hfatty acid measurement QTL GWAS905553 (human)6e-11triglyceride measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)194875811148758112Human
407258113GWAS907089_Htriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS907089 (human)5e-08triglycerides:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)194875811148758112Human
406895241GWAS544217_Herythronate measurement QTL GWAS544217 (human)0.0000003erythronate measurement194875659948756600Human
407165325GWAS814301_Halkaline phosphatase measurement QTL GWAS814301 (human)9e-46alkaline phosphatase measurementblood alkaline phosphatase activity level (CMO:0000576)194875737148757372Human
407255052GWAS904028_Htaste liking measurement QTL GWAS904028 (human)2e-35taste liking measurement194875627248756273Human
407336076GWAS985052_Htriglyceride measurement QTL GWAS985052 (human)1e-23triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407279752GWAS928728_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS928728 (human)3e-10fatty acid measurementblood high density lipoprotein cholesterol level (CMO:0000052)194875811148758112Human
407368215GWAS1017191_Hblood protein measurement QTL GWAS1017191 (human)1e-15blood protein measurementblood protein measurement (CMO:0000028)194875606448756065Human
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
407313297GWAS962273_Hprotein intake measurement QTL GWAS962273 (human)6e-28eating behavior trait (VT:0001431)194875627248756273Human
407325339GWAS974315_Hdiet measurement QTL GWAS974315 (human)9e-29diet measurementfood intake measurement (CMO:0000772)194875627248756273Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human
406913313GWAS562289_Hdiet measurement QTL GWAS562289 (human)8e-10diet measurementfood intake measurement (CMO:0000772)194875627248756273Human
407079971GWAS728947_Hsodium measurement QTL GWAS728947 (human)2e-25sodium measurementblood sodium level (CMO:0000499)194875627248756273Human
407130785GWAS779761_Htriglyceride:HDL cholesterol ratio QTL GWAS779761 (human)0.000002triglyceride:HDL cholesterol ratio194875627248756273Human
407313068GWAS962044_Hcarbohydrate intake measurement QTL GWAS962044 (human)3e-17eating behavior trait (VT:0001431)194875627248756273Human
407279786GWAS928762_Htaste liking measurement QTL GWAS928762 (human)1e-24taste liking measurement194875627248756273Human
407329579GWAS978555_Hfatty acid measurement QTL GWAS978555 (human)2e-11fatty acid measurement194875659948756600Human
407311018GWAS959994_Htriglyceride measurement QTL GWAS959994 (human)4e-27triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407333672GWAS982648_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS982648 (human)3e-15triglyceride measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)194875811148758112Human
407275830GWAS924806_Htaste liking measurement QTL GWAS924806 (human)1e-29taste liking measurement194875627248756273Human
407269556GWAS918532_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS918532 (human)6e-12triglyceride measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)194875811148758112Human
407315892GWAS964868_Hblood urea nitrogen measurement QTL GWAS964868 (human)2e-66blood urea nitrogen measurementblood urea nitrogen level (CMO:0000049)194875627248756273Human
407281205GWAS930181_Htaste liking measurement QTL GWAS930181 (human)8e-21taste liking measurement194875627248756273Human
407338292GWAS987268_Htriglyceride measurement QTL GWAS987268 (human)1e-37triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407275825GWAS924801_Htaste liking measurement QTL GWAS924801 (human)3e-13taste liking measurement194875627248756273Human
407279409GWAS928385_Htriglyceride measurement, low density lipoprotein cholesterol measurement QTL GWAS928385 (human)2e-13triglyceride measurement, very low density lipoprotein cholesterol measurementblood very low density lipoprotein cholesterol level (CMO:0000648)194875811148758112Human
406900027GWAS549003_Htriglyceride measurement QTL GWAS549003 (human)8e-29triglyceride measurementblood triglyceride level (CMO:0000118)194875627248756273Human
407280058GWAS929034_Htaste liking measurement QTL GWAS929034 (human)6e-13taste liking measurement194875627248756273Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
622 824 1394 778 2122 1031 1290 2 492 761 432 970 3191 2525 28 1587 215 864 779 67

Sequence


Ensembl Acc Id: ENST00000222157   ⟹   ENSP00000222157
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,756,087 - 48,758,333 (+)Ensembl
Ensembl Acc Id: ENST00000593756   ⟹   ENSP00000471477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,755,524 - 48,758,330 (+)Ensembl
RefSeq Acc Id: NM_019113   ⟹   NP_061986
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,755,524 - 48,758,330 (+)NCBI
GRCh371949,258,816 - 49,261,587 (+)NCBI
Build 361953,951,156 - 53,953,394 (+)NCBI Archive
HuRef1945,638,191 - 45,640,357 (+)ENTREZGENE
CHM1_11949,260,587 - 49,263,358 (+)NCBI
T2T-CHM13v2.01951,749,989 - 51,752,722 (+)NCBI
Sequence:
RefSeq Acc Id: NP_061986   ⟸   NM_019113
- Peptide Label: precursor
- UniProtKB: Q8N683 (UniProtKB/Swiss-Prot),   Q9NSA1 (UniProtKB/Swiss-Prot),   A0A7U3L5M7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000222157   ⟸   ENST00000222157
Ensembl Acc Id: ENSP00000471477   ⟸   ENST00000593756

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NSA1-F1-model_v2 AlphaFold Q9NSA1 1-209 view protein structure

Promoters
RGD ID:13205015
Promoter ID:EPDNEW_H26088
Type:initiation region
Name:FGF21_2
Description:fibroblast growth factor 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26089  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,755,524 - 48,755,584EPDNEW
RGD ID:13205017
Promoter ID:EPDNEW_H26089
Type:multiple initiation site
Name:FGF21_1
Description:fibroblast growth factor 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26088  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,756,071 - 48,756,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3678 AgrOrtholog
COSMIC FGF21 COSMIC
Ensembl Genes ENSG00000105550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000222157.5 UniProtKB/Swiss-Prot
  ENST00000593756 ENTREZGENE
  ENST00000593756.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105550 GTEx
HGNC ID HGNC:3678 ENTREZGENE
Human Proteome Map FGF21 Human Proteome Map
InterPro FGF15/19/21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26291 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26291 ENTREZGENE
OMIM 609436 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF81 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28117 PharmGKB
PIRSF FGF-19_FGF-21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7U3L5M7 ENTREZGENE, UniProtKB/TrEMBL
  FGF21_HUMAN UniProtKB/Swiss-Prot
  Q8N683 ENTREZGENE
  Q9NSA1 ENTREZGENE
UniProt Secondary Q8N683 UniProtKB/Swiss-Prot