FGF21 (fibroblast growth factor 21) - Rat Genome Database

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Gene: FGF21 (fibroblast growth factor 21) Canis lupus familiaris
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Symbol: FGF21
Name: fibroblast growth factor 21
RGD ID: 12187446
Description: ENCODES a protein that exhibits fibroblast growth factor receptor binding (inferred); growth factor activity (inferred); INVOLVED IN cellular response to glucagon stimulus (ortholog); cellular response to glucose stimulus (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); Cardiomegaly (ortholog); Carotid Atherosclerosis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,571,449 - 107,576,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,571,446 - 107,573,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,093,881 - 107,096,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,096,091 - 108,098,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,096,198 - 108,097,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,762,951 - 107,765,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,409,841 - 107,412,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,245,446 - 108,247,884 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
extracellular region  (IEA)
extracellular space  (IBA,IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,571,449 - 107,576,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,571,446 - 107,573,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,093,881 - 107,096,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,096,091 - 108,098,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,096,198 - 108,097,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,762,951 - 107,765,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,409,841 - 107,412,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,245,446 - 108,247,884 (-)NCBIUU_Cfam_GSD_1.0
FGF21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,755,524 - 48,758,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,755,524 - 48,758,333 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,258,781 - 49,261,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,951,156 - 53,953,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,951,305 - 53,953,289NCBI
Celera1946,125,436 - 46,127,638 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,638,191 - 45,640,357 (+)NCBIHuRef
CHM1_11949,261,115 - 49,263,353 (+)NCBICHM1_1
T2T-CHM13v2.01951,749,989 - 51,752,722 (+)NCBIT2T-CHM13v2.0
Fgf21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,263,314 - 45,264,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,263,310 - 45,264,914 (-)EnsemblGRCm39 Ensembl
GRCm38745,613,890 - 45,615,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,613,886 - 45,615,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,869,260 - 52,870,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36735,187,750 - 35,189,350 (-)NCBIMGSCv36mm8
MGSCv36745,481,932 - 45,483,532 (-)NCBIMGSCv36mm8
Celera741,070,177 - 41,081,186 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.38NCBI
Fgf21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,219,825 - 105,221,376 (-)NCBIGRCr8
mRatBN7.2196,083,360 - 96,084,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,083,441 - 96,090,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,468,930 - 101,470,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,941,627 - 109,942,870 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,232,004 - 103,233,247 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,595,579 - 101,596,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,595,579 - 101,596,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,674,359 - 102,675,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,082,475 - 96,083,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,160,585 - 96,161,829 (-)NCBI
Celera190,337,152 - 90,338,395 (-)NCBICelera
Cytogenetic Map1q22NCBI
Fgf21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,817,110 - 1,820,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,818,400 - 1,821,423 (-)NCBIChiLan1.0ChiLan1.0
FGF21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,858,680 - 54,863,094 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,785,023 - 56,789,078 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,755,466 - 45,758,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,345,966 - 54,347,712 (+)NCBIpanpan1.1PanPan1.1panPan2
Fgf21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,208,545 - 21,210,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,826,823 - 2,828,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,826,823 - 2,828,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,080,739 - 54,084,601 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,082,653 - 54,084,532 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,828,972 - 49,831,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,006,125 - 42,008,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,006,064 - 42,008,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,876,517 - 21,879,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,164,856 - 5,167,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,165,195 - 5,166,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF21
51 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 1 8 3
Below cutoff 1 13 5 6 3 10 7 2

Sequence


RefSeq Acc Id: ENSCAFT00000006274   ⟹   ENSCAFP00000005813
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1107,571,446 - 107,573,281 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001302   ⟹   ENSCAFP00845001002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1108,096,198 - 108,097,768 (-)Ensembl
RefSeq Acc Id: XM_022424196   ⟹   XP_022279904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11107,571,449 - 107,576,630 (-)NCBI
Dog10K_Boxer_Tasha1107,093,881 - 107,095,832 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465051   ⟹   XP_038320979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,762,951 - 107,764,902 (-)NCBI
RefSeq Acc Id: XM_038465052   ⟹   XP_038320980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,762,951 - 107,765,389 (-)NCBI
RefSeq Acc Id: XM_038525646   ⟹   XP_038381574
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01108,245,446 - 108,247,397 (-)NCBI
RefSeq Acc Id: XM_038525647   ⟹   XP_038381575
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01108,245,446 - 108,247,884 (-)NCBI
RefSeq Acc Id: XM_038589850   ⟹   XP_038445778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01107,409,841 - 107,411,792 (-)NCBI
RefSeq Acc Id: XM_038589851   ⟹   XP_038445779
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01107,409,841 - 107,412,279 (-)NCBI
RefSeq Acc Id: XM_038653775   ⟹   XP_038509703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01108,096,091 - 108,098,042 (-)NCBI
RefSeq Acc Id: XM_038653776   ⟹   XP_038509704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01108,096,091 - 108,098,529 (-)NCBI
RefSeq Acc Id: XM_541510   ⟹   XP_541510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11107,571,449 - 107,574,670 (-)NCBI
Dog10K_Boxer_Tasha1107,093,881 - 107,096,319 (-)NCBI
Sequence:
RefSeq Acc Id: XP_541510   ⟸   XM_541510
- UniProtKB: E2RRP8 (UniProtKB/TrEMBL),   A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279904   ⟸   XM_022424196
- UniProtKB: A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL),   E2RRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005813   ⟸   ENSCAFT00000006274
RefSeq Acc Id: XP_038320980   ⟸   XM_038465052
RefSeq Acc Id: XP_038320979   ⟸   XM_038465051
RefSeq Acc Id: XP_038445779   ⟸   XM_038589851
RefSeq Acc Id: XP_038445778   ⟸   XM_038589850
RefSeq Acc Id: XP_038509704   ⟸   XM_038653776
- UniProtKB: A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL),   E2RRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509703   ⟸   XM_038653775
- UniProtKB: A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL),   E2RRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381575   ⟸   XM_038525647
- UniProtKB: A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL),   E2RRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381574   ⟸   XM_038525646
- UniProtKB: A0A8C0LL57 (UniProtKB/TrEMBL),   A0A8C0N592 (UniProtKB/TrEMBL),   E2RRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001002   ⟸   ENSCAFT00845001302


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003904 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013355 UniProtKB/TrEMBL
  ENSCAFG00040000928 UniProtKB/TrEMBL
  ENSCAFG00845000788 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006274.3 UniProtKB/TrEMBL
  ENSCAFT00030024709.1 UniProtKB/TrEMBL
  ENSCAFT00040001677.1 UniProtKB/TrEMBL
  ENSCAFT00845001302 ENTREZGENE
  ENSCAFT00845001302.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF21 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF81 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A8C0LL57 ENTREZGENE
  A0A8C0N592 ENTREZGENE, UniProtKB/TrEMBL
  E2RRP8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40848 ENTREZGENE