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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ubiquinone-0
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Accession:CHEBI:27906 term browser browse the term
Definition:A derivative of benzoquinone carrying a 5-methyl substituent; and methoxy substituents at positions 2 and 3. The core structure of the ubiquinone group of compounds.
Synonyms:exact_synonym: 2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione
 related_synonym: 2,3-dimethoxy-5-methyl-1,4-benzoquinone;   2,3-dimethoxy-5-methyl-p-benzoquinone;   2,3-dimethoxy-5-methylbenzo-1,4-quinone;   2,3-dimethoxy-5-methylbenzoquinone;   2-methyl-4,5-dimethoxy-p-quinone;   2-methyl-5,6-dimethoxybenzoquinone;   CoQ0;   Formula=C9H10O4;   InChI=1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3;   InChIKey=UIXPTCZPFCVOQF-UHFFFAOYSA-N;   Q0;   SMILES=COC1=C(OC)C(=O)C(C)=CC1=O;   coenzyme Q0
 alt_id: CHEBI:27184;   CHEBI:9853
 xref: Beilstein:1640422;   CAS:605-94-7;   Gmelin:281282;   KEGG:C05251
 xref_mesh: MESH:C109863
 xref: MetaCyc:CPD0-1464;   PMID:11748217;   PMID:18830129;   PMID:9413934


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ubiquinone-0 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO ubiquinone-O results in decreased expression of ALDH1 protein CTD PMID:36847822 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Casp1 caspase 1 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of CASP1 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]		 CTD PMID:36847822 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cd24 CD24 molecule increases expression ISO ubiquinone-O results in increased expression of CD24 protein CTD PMID:36847822 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO ubiquinone-O results in decreased expression of CD44 protein CTD PMID:36847822 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO ubiquinone-O results in increased expression of CDH1 mRNA; ubiquinone-O results in increased expression of CDH1 protein CTD PMID:36847822 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO ubiquinone-O results in decreased expression of CDH2 mRNA; ubiquinone-O results in decreased expression of CDH2 protein CTD PMID:36847822 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO ubiquinone-O results in decreased expression of HIF1A protein CTD PMID:36847822 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 decreases expression ISO ubiquinone-O results in decreased expression of HK2 protein CTD PMID:36847822 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Il18 interleukin 18 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of IL18 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]		 CTD PMID:36847822 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of IL1B protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]		 CTD PMID:36847822 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO ubiquinone-O results in decreased expression of LDHA protein CTD PMID:36847822 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA] CTD PMID:36847822 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA] CTD PMID:36847822 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of NLRP3 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]		 CTD PMID:36847822 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein]
ubiquinone-O results in decreased expression of NOS2 protein		 CTD PMID:36847822 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO ubiquinone-O results in decreased expression of PDK1 protein CTD PMID:36847822 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO ubiquinone-O results in decreased expression of PKM protein CTD PMID:36847822 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO ubiquinone-O results in decreased expression of PYCARD protein CTD PMID:36847822 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO ubiquinone-O results in decreased expression of SLC2A1 mRNA; ubiquinone-O results in decreased expression of SLC2A1 protein CTD PMID:36847822 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO ubiquinone-O results in decreased expression of TLR4 protein CTD PMID:36847822 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            prokaryotic metabolite 18561
              bacterial metabolite 18561
                Escherichia coli metabolite 18473
                  ubiquinone-0 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      cyclic ketone 15685
                                        quinone 8644
                                          benzoquinones 785
                                            1,4-benzoquinones 782
                                              monohydroxy-1,4-benzoquinones 110
                                                2-hydroxy-5-methylquinone 104
                                                  2,3-dihydroxy-5-methyl-1,4-benzoquinone 104
                                                    ubiquinones 104
                                                      ubiquinone-0 20
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