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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ubiquinones
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Accession:CHEBI:16389 term browser browse the term
Definition:Any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.
Synonyms:related_synonym: CoQ;   Coenzym Q;   Coenzyme Q;   Formula=C9H10O4(C5H8)n;   Koenzym Q;   Q;   Ubichinon;   Ubiquinone;   a ubiquinone;   coenzymes Q;   mitochondrial ubiquinone;   mitochondrial ubiquinones;   mitoquinones
 alt_id: CHEBI:15279;   CHEBI:27186;   CHEBI:9852
 xref: CAS:1339-63-5;   KEGG:C00399
 xref_mesh: MESH:D014451
 xref: PMID:15788391;   PMID:7599208


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ubiquinones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:20584200 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver RGD PMID:29156373 RGD:15036805 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]		 CTD PMID:12880480 PMID:24732427 PMID:35866224 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity EXP Ubiquinone results in increased activity of CAT protein CTD PMID:20034476 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Coq8a coenzyme Q8A increases chemical synthesis ISO COQ8A protein results in increased chemical synthesis of Ubiquinone CTD PMID:18319072 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431 		JBrowse link
G Dhodh dihydroorotate dehydrogenase multiple interactions
increases metabolic processing		 ISO
EXP		 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of Ubiquinone
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]		 CTD PMID:9802339 PMID:11248707 NCBI chr19:54,460,636...54,483,049
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of GPT protein] CTD PMID:35866224 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] CTD PMID:17516992 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] CTD PMID:17516992 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3] CTD PMID:20020783 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone] CTD PMID:10731415 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] CTD PMID:17516992 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases reduction
decreases oxidation		 ISO XRCC1 gene mutant form results in decreased reduction of Ubiquinone
XRCC1 results in decreased oxidation of Ubiquinone		 CTD PMID:30998386 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
coenzyme Q10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein] CTD PMID:35547012 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] CTD PMID:27087047 PMID:27345130 PMID:32383521 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein CTD PMID:33754447 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:22186599 PMID:32383521 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] CTD PMID:21370964 NCBI chr14:50,921,323...51,120,972
Ensembl chr14:46,718,760...46,917,154 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:27087047 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] CTD PMID:27087047 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]		 CTD PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; coenzyme Q10 inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein] CTD PMID:35547012 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 coenzyme Q10 results in increased expression of BCL2 mRNA
[coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]		 CTD PMID:18817789 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:27087047 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G C1qa complement C1q A chain decreases expression ISO coenzyme Q10 results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C4b complement C4B decreases expression ISO coenzyme Q10 results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]		 CTD PMID:20510337 PMID:22186599 PMID:27087047 PMID:32116774 PMID:33393703 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:27087047 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions EXP
ISO		 [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]		 CTD PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:27087047 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO coenzyme Q10 results in increased expression of CCND1 protein CTD PMID:34668565 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] CTD PMID:27087047 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein] CTD PMID:34668565 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA] CTD PMID:34186417 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSD protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSD mRNA] CTD PMID:34186417 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctss cathepsin S decreases expression ISO coenzyme Q10 results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA] CTD PMID:33856607 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] CTD PMID:21370964 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] CTD PMID:21370964 NCBI chr 2:175,263,389...175,278,217
Ensembl chr 2:172,965,588...172,980,314 		JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] CTD PMID:27087047 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Faslg Fas ligand multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] CTD PMID:27087047 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein] CTD PMID:33548410 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions		 ISO
EXP		 coenzyme Q10 results in decreased expression of GFAP mRNA
[Oxygen co-treated with coenzyme Q10] results in decreased expression of GFAP protein		 CTD PMID:19555370 PMID:35212449 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein] CTD PMID:27387968 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27387968 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]		 CTD PMID:27174133 PMID:27387968 PMID:33271250 PMID:33393703 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO
EXP		 coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA]
[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GPX1 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]		 CTD PMID:32116774 PMID:33271250 PMID:37967787 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO		 coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]		 CTD PMID:22186599 PMID:34668565 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression		 EXP [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]
coenzyme Q10 results in increased expression of GSR mRNA		 CTD PMID:19958828 PMID:32116774 PMID:33393703 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] CTD PMID:27174133 PMID:32116774 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO
EXP		 [Valproic Acid co-treated with coenzyme Q10] inhibits the reaction [Benzene results in increased expression of IL10 protein]
coenzyme Q10 results in increased expression of IL10 mRNA; coenzyme Q10 results in increased expression of IL10 protein
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein]		 CTD PMID:32116774 PMID:35090963 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein] CTD PMID:32116774 PMID:32383521 PMID:34939713 PMID:37967787 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 CTD PMID:15256069 NCBI chr11:47,531,312...47,778,348
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of LAMP2 protein] CTD PMID:34186417 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity		 EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
coenzyme Q10 results in increased activity of LDHC protein		 CTD PMID:33548410 NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:37967787 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:37967787 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:37967787 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:27087047 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:27087047 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP		 [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
coenzyme Q10 inhibits the reaction [Methotrexate results in increased activity of MPO protein]		 CTD PMID:26519479 PMID:33745333 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt3 metallothionein 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein] CTD PMID:33856607 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] CTD PMID:21370964 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 increases expression
multiple interactions		 ISO coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]		 CTD PMID:19523936 NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:55,400,543...55,410,181 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO coenzyme Q10 results in increased expression of NDUFS7 protein CTD PMID:19523936 NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein] CTD PMID:34939713 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein] CTD PMID:33754447 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 EXP
ISO		 coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 results in increased expression of NFE2L2 mRNA
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]		 CTD PMID:27174133 PMID:32116774 PMID:33271250 PMID:34939713 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]		 CTD PMID:20510337 PMID:32116774 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein] CTD PMID:33754447 NCBI chr 1:74,521,626...74,529,119
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO coenzyme Q10 results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA]
coenzyme Q10 results in increased expression of PCNA protein		 CTD PMID:31557371 PMID:34668565 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein] CTD PMID:33271250 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] CTD PMID:21370964 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:78,130,685...78,263,363 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] CTD PMID:21370964 NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein] CTD PMID:33271250 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] CTD PMID:21370964 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 protein] CTD PMID:37967787 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein] CTD PMID:34939713 PMID:37967787 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA] CTD PMID:34939713 NCBI chr10:63,867,503...63,890,872
Ensembl chr10:63,369,456...63,392,822 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased expression of SCARB1 protein] CTD PMID:37967787 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO coenzyme Q10 results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snca synuclein alpha multiple interactions ISO
EXP		 coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein		 CTD PMID:15114628 PMID:19476553 PMID:21843543 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of SOD1 protein] CTD PMID:37967787 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 affects expression
increases expression
multiple interactions		 EXP
ISO		 coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 results in increased expression of SOD2 mRNA
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]		 CTD PMID:22083459 PMID:24008411 PMID:32116774 PMID:33271250 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:33271250 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased expression of STAR protein] CTD PMID:37967787 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] CTD PMID:27087047 PMID:27174133 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein]		 CTD PMID:20510337 PMID:26519479 PMID:32116774 PMID:32383521 PMID:34939713 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein]		 CTD PMID:20510337 PMID:33393703 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
ubiquinone-0 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO ubiquinone-O results in decreased expression of ALDH1 protein CTD PMID:36847822 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Casp1 caspase 1 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of CASP1 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]		 CTD PMID:36847822 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cd24 CD24 molecule increases expression ISO ubiquinone-O results in increased expression of CD24 protein CTD PMID:36847822 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO ubiquinone-O results in decreased expression of CD44 protein CTD PMID:36847822 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO ubiquinone-O results in increased expression of CDH1 mRNA; ubiquinone-O results in increased expression of CDH1 protein CTD PMID:36847822 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO ubiquinone-O results in decreased expression of CDH2 mRNA; ubiquinone-O results in decreased expression of CDH2 protein CTD PMID:36847822 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO ubiquinone-O results in decreased expression of HIF1A protein CTD PMID:36847822 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 decreases expression ISO ubiquinone-O results in decreased expression of HK2 protein CTD PMID:36847822 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Il18 interleukin 18 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of IL18 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]		 CTD PMID:36847822 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of IL1B protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]		 CTD PMID:36847822 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO ubiquinone-O results in decreased expression of LDHA protein CTD PMID:36847822 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA] CTD PMID:36847822 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA] CTD PMID:36847822 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions		 ISO ubiquinone-O results in decreased expression of NLRP3 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]		 CTD PMID:36847822 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein]
ubiquinone-O results in decreased expression of NOS2 protein		 CTD PMID:36847822 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO ubiquinone-O results in decreased expression of PDK1 protein CTD PMID:36847822 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO ubiquinone-O results in decreased expression of PKM protein CTD PMID:36847822 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO ubiquinone-O results in decreased expression of PYCARD protein CTD PMID:36847822 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO ubiquinone-O results in decreased expression of SLC2A1 mRNA; ubiquinone-O results in decreased expression of SLC2A1 protein CTD PMID:36847822 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO ubiquinone-O results in decreased expression of TLR4 protein CTD PMID:36847822 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
ubiquinone-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1 CTD PMID:20399199 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
ubiquinone-9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9 CTD PMID:15256069 NCBI chr11:47,531,312...47,778,348
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          metabolite 19573
            prokaryotic metabolite 18614
              bacterial metabolite 18614
                Escherichia coli metabolite 18524
                  ubiquinones 111
                    (2Z,10Z,26Z)-ubiquinone 0
                    (R)-3,4-Dimethoxydalbergione 0
                    (R)-4'-Hydroxy-3,4-dimethoxydalbergione 0
                    2,3-dimethoxy-5-(3-oxobutan-2-yl)cyclohexa-2,5-diene-1,4-dione 0
                    3-demethylubiquinone(1-) + 0
                    3-demethylubiquinone-9 0
                    5-(3-hydroxybutan-2-yl)-2,3-dimethoxycyclohexa-2,5-diene-1,4-dione 0
                    Antroquinonol N 0
                    Asperphenone A 0
                    Atrovirinone 0
                    Coenzyme Q4 0
                    Coptirhoquinone A 0
                    Fumiquinone A 0
                    Fumiquinone B 0
                    Methylpedicinin 0
                    Myrsinone 0
                    Pseudoalteromone A 0
                    coenzyme Q10 87
                    ubiquinone-0 20
                    ubiquinone-1 1
                    ubiquinone-2 0
                    ubiquinone-5 0
                    ubiquinone-6 0
                    ubiquinone-7 0
                    ubiquinone-8 0
                    ubiquinone-9 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbonyl compound 18947
                                    ketone 17281
                                      cyclic ketone 15929
                                        quinone 9916
                                          benzoquinones 802
                                            1,4-benzoquinones 799
                                              monohydroxy-1,4-benzoquinones 116
                                                2-hydroxy-5-methylquinone 111
                                                  2,3-dihydroxy-5-methyl-1,4-benzoquinone 111
                                                    ubiquinones 111
                                                      (2Z,10Z,26Z)-ubiquinone 0
                                                      (R)-3,4-Dimethoxydalbergione 0
                                                      (R)-4'-Hydroxy-3,4-dimethoxydalbergione 0
                                                      2,3-dimethoxy-5-(3-oxobutan-2-yl)cyclohexa-2,5-diene-1,4-dione 0
                                                      3-demethylubiquinone(1-) + 0
                                                      3-demethylubiquinone-9 0
                                                      5-(3-hydroxybutan-2-yl)-2,3-dimethoxycyclohexa-2,5-diene-1,4-dione 0
                                                      Antroquinonol N 0
                                                      Asperphenone A 0
                                                      Atrovirinone 0
                                                      Coenzyme Q4 0
                                                      Coptirhoquinone A 0
                                                      Fumiquinone A 0
                                                      Fumiquinone B 0
                                                      Methylpedicinin 0
                                                      Myrsinone 0
                                                      Pseudoalteromone A 0
                                                      coenzyme Q10 87
                                                      ubiquinone-0 20
                                                      ubiquinone-1 1
                                                      ubiquinone-2 0
                                                      ubiquinone-5 0
                                                      ubiquinone-6 0
                                                      ubiquinone-7 0
                                                      ubiquinone-8 0
                                                      ubiquinone-9 1
paths to the root