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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amitraz
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Accession:CHEBI:2665 term browser browse the term
Definition:A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
Synonyms:exact_synonym: N'-(2,4-dimethylphenyl)-N-{[(2,4-dimethylphenyl)imino]methyl}-N-methylmethanimidamide
 related_synonym: 1,5-di(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene;   Formula=C19H23N3;   InChI=1S/C19H23N3/c1-14-6-8-18(16(3)10-14)20-12-22(5)13-21-19-9-7-15(2)11-17(19)4/h6-13H,1-5H3;   InChIKey=QXAITBQSYVNQDR-UHFFFAOYSA-N;   Mitac;   N,N'-(methyliminodimethylidyne)bis-2,4-xylidine;   SMILES=CN(C=Nc1ccc(C)cc1C)C=Nc1ccc(C)cc1C
 xref: Beilstein:2946590;   CAS:33089-61-1;   KEGG:C10995;   KEGG:D02380
 xref_mesh: MESH:C014983
 xref: PMID:10885999;   PMID:15822764;   PMID:24288053;   PMID:25053051;   PPDB:30;   Pesticides:amitraz;   Reaxys:2946590;   VSDB:30;   Wikipedia:Amitraz


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amitraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions
decreases activity		 EXP
ISO		 [Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz; amitraz binds to and results in increased activity of ADRA2A protein
amitraz results in decreased activity of ADRA2A protein		 CTD PMID:10582558 PMID:21251949 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 EXP amitraz results in decreased expression of CAT protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]		 CTD PMID:31029719 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects expression		 EXP Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA]; Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein]
amitraz affects the expression of COMT mRNA; amitraz affects the expression of COMT protein		 CTD PMID:28463726 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP19A1 mRNA; amitraz results in increased expression of CYP19A1 protein CTD PMID:28463726 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP1A1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP1A2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2B1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP2B2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2E1 protein CTD PMID:31029719 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP amitraz results in increased expression of CYP3A23-3A1 protein CTD PMID:31029719 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression		 EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH protein]
amitraz results in increased expression of DBH mRNA; amitraz results in increased expression of DBH protein		 CTD PMID:28463726 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO amitraz inhibits the reaction [Spiperone binds to DRD2 protein] CTD PMID:2833825 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
multiple interactions		 EXP amitraz affects the expression of GAD2 mRNA
[methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; Idazoxan inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; methylhistaprodifen inhibits the reaction [amitraz affects the expression of GAD2 mRNA]		 CTD PMID:26141220 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gcg glucagon increases secretion EXP amitraz results in increased secretion of GCG protein CTD PMID:10582558 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gls glutaminase multiple interactions
increases expression		 EXP [methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz results in increased expression of GLS mRNA]; methylhistaprodifen inhibits the reaction [amitraz results in increased expression of GLS mRNA] CTD PMID:26141220 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions		 EXP amitraz results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]		 CTD PMID:31029719 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP amitraz results in increased expression of LHB protein CTD PMID:16085667 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Maoa monoamine oxidase A multiple interactions
decreases expression		 EXP Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA protein]
amitraz results in decreased expression of MAOA mRNA; amitraz results in decreased expression of MAOA protein		 CTD PMID:28463726 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases expression
multiple interactions		 EXP amitraz results in decreased expression of MAOB mRNA; amitraz results in decreased expression of MAOB protein
Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB protein]		 CTD PMID:28463726 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 EXP amitraz results in decreased expression of NFE2L2 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]		 CTD PMID:31029719 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 EXP amitraz results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]		 CTD PMID:31029719 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP amitraz results in increased activity of POR protein CTD PMID:15350676 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO amitraz inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions		 EXP amitraz results in decreased expression of SOD1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]		 CTD PMID:31029719 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression		 EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
amitraz results in increased expression of TH mRNA; amitraz results in increased expression of TH protein		 CTD PMID:28463726 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          amitraz 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        tertiary amino compound 10131
                                          amitraz 25
paths to the root