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5'-S-methyl-5'-thioadenosine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5'-S-methyl-5'-thioadenosine
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Accession:CHEBI:17509 term browser browse the term
Definition:Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.
Synonyms:exact_synonym: 5'-deoxy-5'-(methylsulfanyl)adenosine
 related_synonym: 5'-Deoxy-5'-(methylthio)adenosine;   5-Methylthioadenosine;   9-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-9H-purin-6-amine;   Formula=C11H15N5O3S;   InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1;   InChIKey=WUUGFSXJNOTRMR-IOSLPCCCSA-N;   MTA;   Methylthioadenosine;   S-Methyl-5-thioadenosine;   SMILES=CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12;   Thiomethyladenosine
 alt_id: CHEBI:12055;   CHEBI:12064;   CHEBI:12771;   CHEBI:14605;   CHEBI:1966;   CHEBI:1986;   CHEBI:20491;   CHEBI:20494;   CHEBI:44181
 xref: Beilstein:42420;   CAS:2457-80-9;   DrugBank:DB02282;   HMDB:HMDB0001173;   KEGG:C00170
 xref_mesh: MESH:C008500
 xref: MetaCyc:5-METHYLTHIOADENOSINE;   PMID:22735334;   Reaxys:42420

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5'-S-methyl-5'-thioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adora2b adenosine A2B receptor multiple interactions ISO 5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts] RGD PMID:21209952 RGD:153297773 NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO 5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]		 CTD PMID:31712395 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A1 mRNA
5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts		 CTD
RGD		 PMID:15983038 PMID:21209952 RGD:153297773 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]		 CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion		 ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA]
5'-methylthioadenosine results in decreased secretion of IFNG protein		 CTD PMID:17080400 PMID:31712395 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifnl1 interferon, lambda 1 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] CTD PMID:37611859 NCBI chr 1:92,926,184...92,927,830
Ensembl chr 1:83,798,703...83,800,235 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] CTD PMID:17080400 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases secretion		 ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA]
5'-methylthioadenosine results in decreased secretion of IL2 protein		 CTD PMID:17080400 PMID:31712395 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il33 interleukin 33 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] CTD PMID:37545493 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver		 CTD
RGD		 PMID:17080400 PMID:21209952 RGD:153297773 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7 interleukin 7 multiple interactions ISO IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein] CTD PMID:31712395 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Ltb lymphotoxin beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO 5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form CTD PMID:31712395 NCBI chr13:46,922,236...47,068,241
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver RGD PMID:21209952 RGD:153297773 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver RGD PMID:21209952 RGD:153297773 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO 5'-methylthioadenosine results in decreased phosphorylation of MTOR protein CTD PMID:31712395 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver RGD PMID:21209952 RGD:153297773 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO 5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein CTD PMID:31712395 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts RGD PMID:21209952 RGD:153297773 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnc tenascin C decreases expression ISO 5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver RGD PMID:21209952 RGD:153297773 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts] RGD PMID:21209952 RGD:153297773 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO 5'-methylthioadenosine results in increased expression of TP53 protein CTD PMID:31712395 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        pharmacological role 19088
          analgesic 14772
            adenosine 414
              5'-S-methyl-5'-thioadenosine 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbohydrates and carbohydrate derivatives 15309
                                    carbohydrate 15309
                                      carbohydrate derivative 14335
                                        glycosyl compound 13075
                                          N-glycosyl compound 5884
                                            nucleoside 5743
                                              ribonucleoside 1167
                                                purine ribonucleoside 825
                                                  purines D-ribonucleoside 427
                                                    adenosine 414
                                                      thioadenosine 28
                                                        5'-S-methyl-5'-thioadenosine 28
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