Gene:	Mapk8 ( Rattus norvegicus ) mitogen-activated protein kinase 8
Description:	a stress-activated protein kinase
Synonyms:	JNK; c-jun NH2-terminal kinase;
ArrayIDs:	rc_AI029013_at; 1392418_at; 1379612_at; 6698667; 6372791; 5861845; 5995482; L27129_at; rc_AI234869_at; 5673932; 6688725; A_44_P192134; 1382079_at; A_43_P15745; 6119133; 5882075; 6243867; A_44_P259553; 6355612; 6447486; rc_AA851014_at; 5697557; 6308168; 6004975; 6388266; 6235230;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: MAPK8     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Mapk8     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Mapk8 Rat Celera Assembly 16 6485574 - 6564248     RGSC genome assembly v3.4 16 8922497 - 9004965     Cytogenetic 16 p16     genome assembly 3.1 16 8925181 - 9004945 Mus musculus Mapk8 Mouse genome assembly build 36.1 14 34195195 - 34260343     Cytogenetic 14 14 B Homo sapiens MAPK8 human genome assembly 10 49279692 - 49313189     Human genome assembly build 36.2 10 49279693 - 49313189     Cytogenetic 10 q11.22   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology JUN kinase activity,  protein binding,  nucleotide binding ...  (details...)
Biological Process	Gene Ontology ossification,  regulation of transcription, DNA-dependent,  peptidyl-threonine phosphorylation ...  (details...)
Cellular Component	Gene Ontology nucleus,  mitochondrion,  axon part ...  (details...)
Disease	Ontology Brain Ischemia,  Myocardial Reperfusion Injury,  Hypertension ...  (details...)
Pathway	Ontology c-Jun N-terminal kinases MAPK signaling pathway,  Rho/Rac/Cdc42 mediated signaling pathway,  the planar cell polarity Wnt signaling pathway ...  (details...)
Regulation	Note Reference activated by cellular stress, sphingomyelinase and tumour necrosis factor (TNF)-alpha 729029
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: MAPK IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI0001B79E45 IPI UNIPARC: UPI000012F17B IPI UNIPARC: UPI0001B79E43 IPI UNIPARC: UPI0001B79E44 IPI KEGG Report: rno:116554 ENTREZGENE HomoloGene Group ID: 56760 ENTREZGENE Germonline: 621506 Pfam: Pkinase IPI KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04622 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE InterPro: MAP_kinase_CS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: JNK_MAPK. IPI InterPro: Kinase-like_dom. IPI IPI: IPI00191803 IPI IPI: IPI00778838 IPI IPI: IPI00949823 IPI IPI: IPI00764183 IPI Ensembl Protein: ENSRNOP00000027338 IPI Ensembl Protein: ENSRNOP00000052972 IPI Ensembl Protein: ENSRNOP00000062048 IPI Ensembl Protein: ENSRNOP00000062468 IPI Entrez Gene: Mapk8 ENTREZGENE UniProt: MK08_RAT IPI Ensembl Genes: ENSRNOG00000020155 IPI Superfamily-SCOP: Kinase_like IPI PRINTS: JNKMAPKINASE. IPI
Sequences	Nucleotide: CH474046 Get FASTA Search GEO Profiles Nucleotide: EU253566 Get FASTA Search GEO Profiles Nucleotide: L27129 Get FASTA Search GEO Profiles Nucleotide: XM_001056513 Get FASTA Search GEO Profiles Nucleotide: XM_341399 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: ABX46062 Get FASTA Protein: XP_341400 Get FASTA Protein: XP_001056513 Get FASTA Protein: P49185 Get FASTA Protein: AAA42111 Get FASTA Protein: EDL88902 Get FASTA Protein: EDL88901 Get FASTA Protein: EDL88900 Get FASTA Protein: EDL88899 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 4090
References
Curated References	30 references in RGD related to Mapk8
Other References	116 other references at PubMed related to Mapk8
Database Information
RGD ID	621506
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 20-JAN-05: Mapk8 mitogen-activated protein kinase 8 APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Mapk8 mitogen-activated protein kinase 8 PROVISIONAL Symbol and Name status set to provisional 70820