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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDnickel sulfate results in increased phosphorylation of MAPK8 proteinPMID:15588916 PMID:18495191 PMID:19101624 PMID:35499276
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDnickel sulfate results in increased phosphorylation of MAPK8 proteinPMID:18467339
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]; SB 203580 promotes the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]PMID:18495191
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDMAP3K1 protein affects the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]PMID:18467339
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