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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:17183
Term: sanguinarine
Definition: A botanical anti-fungal agent that has formula C20H14NO4.
Chemical ID: MESH:C005705
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDsanguinarine results in increased phosphorylation of MAPK8 proteinPMID:19135517
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein]PMID:19135517
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