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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8decreases activityISOMAPK8 (Homo sapiens)6480464CTDSodium Selenite results in decreased activity of MAPK8 proteinPMID:10644709
Mapk8decreases expressionISOMAPK8 (Homo sapiens)6480464CTDSodium Selenite results in decreased expression of MAPK8 mRNAPMID:18175754
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDSodium Selenite results in increased phosphorylation of MAPK8 proteinPMID:34520753
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of MAPK8 protein]; Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Sodium Selenite results in decreased activity of JUN protein]; Mercaptoethanol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 proteinPMID:10644709 PMID:18728404 PMID:34520753
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK8 protein]PMID:18481333 PMID:26522834
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