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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of MAPK8 mRNAPMID:31150632
Mapk8increases phosphorylationEXP 6480464CTDCarbon Tetrachloride results in increased phosphorylation of MAPK8 proteinPMID:17285312 PMID:19066852
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased phosphorylation of MAPK8 proteinPMID:20589743 PMID:21291945 PMID:31919559
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTD[Acetaminophen co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK8 protein; [AK-1 compound co-treated with Carbon Tetrachloride] results in decreased phosphorylation of MAPK8 protein; [Dietary Fats co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK8 protein; AK-1 compound inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK8 protein]; alisol B inhibits the reaction [[Dietary Fats co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK8 protein]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK8 protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK8 protein]PMID:20589743 PMID:21291945 PMID:29873576 PMID:32063085 PMID:35745142
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