GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | increases activity | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased activity of MAPK8 protein | PMID:11160861 | Mapk8 | increases expression | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased expression of MAPK8 protein | PMID:16051289 | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased phosphorylation of MAPK8 protein | PMID:19426673 | Mapk8 | increases phosphorylation | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | Paclitaxel results in increased phosphorylation of MAPK8 protein | PMID:11123339 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein; [Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased activity of MAPK8 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein]; MAP3K1 protein affects the reaction [Paclitaxel results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Paclitaxel promotes the reaction [MAPK8 protein binds to MAP3K1 protein modified form] | PMID:10075725 PMID:11160861 PMID:16051289 PMID:19944065 | Mapk8 | multiple interactions | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein] | PMID:11123339 | | ||||||||||||||||||||||
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