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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8multiple interactionsEXP 6480464CTDGlutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein]PMID:22767315
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDGlutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]PMID:16112521
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDGlutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]PMID:17481858 PMID:20423716
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