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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTDParaquat results in increased phosphorylation of MAPK8 proteinPMID:16687388 PMID:19080378 PMID:28474156 PMID:30317802 PMID:36394833
Mapk8multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; [[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose; Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]PMID:16687388 PMID:19080378 PMID:28474156 PMID:30317802 PMID:36394833
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDParaquat results in increased phosphorylation of MAPK8 proteinPMID:28474156
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDParaquat results in increased phosphorylation of MAPK8 proteinPMID:28215578
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDMAPK8 protein affects the reaction [Paraquat results in increased expression of MUC5AC mRNA]; MFN2 inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; Paraquat results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]PMID:17018646 PMID:25177032 PMID:28215578 PMID:28474156
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTD[Maneb co-treated with Paraquat] results in increased expression of MAPK8 mRNAPMID:36117858
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