Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTDRotenone results in increased phosphorylation of MAPK8 proteinPMID:30472438
Mapk8multiple interactionsEXP 6480464CTD1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]PMID:30472438
Mapk8increases activityISOMAPK8 (Homo sapiens)6480464CTDRotenone results in increased activity of MAPK8 proteinPMID:10780954
Mapk8increases activityISOMapk8 (Mus musculus)6480464CTDRotenone results in increased activity of MAPK8 proteinPMID:11181820
Mapk8increases expressionISOMAPK8 (Homo sapiens)6480464CTDRotenone results in increased expression of MAPK8 mRNAPMID:32368861
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDRotenone results in increased phosphorylation of MAPK8 proteinPMID:31648047 PMID:32368861
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]; Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Rotenone results in increased phosphorylation of and results in increased activity of MAPK8 protein; SLC2A1 protein inhibits the reaction [Rotenone results in increased activity of MAPK8 protein]PMID:10780954 PMID:14976342 PMID:17395008 PMID:31648047
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDRotenone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]PMID:29906494
Go Back to source page   Continue to Ontology report