GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of MAPK8 mRNA | PMID:26335259 | Mapk8 | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAPK8 protein | PMID:15623433 PMID:16213474 PMID:17384285 PMID:26335259 PMID:35843304 | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased expression of MAPK8 mRNA]; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK8 protein; galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; Taurine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein] | PMID:18346979 PMID:26335259 PMID:35843304 | Mapk8 | affects activity | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the activity of MAPK8 protein | PMID:15870702 | Mapk8 | decreases expression | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of MAPK8 mRNA | PMID:34719826 | Mapk8 | increases activity | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased activity of MAPK8 protein | PMID:15880572 | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAPK8 protein | PMID:15917298 PMID:16890185 PMID:31563593 | Mapk8 | increases response to substance | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | MAPK8 protein results in increased susceptibility to Doxorubicin | PMID:15917298 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | [DLJ14 compound co-treated with Doxorubicin] results in increased phosphorylation of MAPK8 protein; [Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of MAPK8 protein; [Doxorubicin co-treated with cordycepin] results in decreased expression of MAPK8 protein; [Doxorubicin co-treated with Phellinus linteus extract] results in increased expression of and results in increased phosphorylation of and results in increased activity of MAPK8 protein; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; Doxorubicin promotes the reaction [KLF5 protein affects the phosphorylation of MAPK8 protein]; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK8 protein; GSTA1 protein inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; KLF5 protein affects the reaction [Doxorubicin results in decreased phosphorylation of MAPK8 protein]; Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]; rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein] | PMID:15494689 PMID:15917298 PMID:16868541 PMID:16890185 PMID:21214929 PMID:21402141 PMID:32173973 PMID:34719826 PMID:35186504 | | ||||||||||||||||||||||
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