RGD Reference Report - Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection. - Rat Genome Database

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Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection.

Authors: Pantos, C  Malliopoulou, V  Mourouzis, I  Moraitis, P  Tzeis, S  Thempeyioti, A  Paizis, I  Cokkinos, A  Carageorgiou, H  Varonos, DD  Cokkinos, DV 
Citation: Pantos C, etal., Basic Res Cardiol. 2003 May;98(3):158-64.
RGD ID: 1582312
Pubmed: PMID:12883833   (View Abstract at PubMed)
DOI: DOI:10.1007/s00395-003-0399-6   (Journal Full-text)

The present study investigated whether heat stress-induced cardioprotection involves alterations in the pattern of p38 mitogen activated protein kinase (p38MAPK) and c-Jun NH2 - terminal kinase (JNK) activation during ischaemia - reperfusion in a model of isolated perfused rat heart. Wistar rats were subjected to whole-body hyperthermia at 42 degrees C for 15 min (HS), while untreated animals served as controls (CON). Twenty four hours later, CON and HS isolated hearts were perfused in a Langendorff mode and subjected to 20 min of zero-.ow global ischaemia followed by 45 min of reperfusion. Postischaemic recovery of left ventricular developed pressure at 45 min of reperfusion was expressed as % of the initial value (LVDP%). Activation of p38 MAPK and JNK was assessed by standard Western blotting techniques using a dual phospho-p38 MAPK and phospho-p46 JNK and p54 JNK antibodies. The levels of phospho-p38 MAPK at the end of reperfusion were not different in HS as compared to CON hearts. The levels of phospho-p46 JNK and p54 JNK were 1.4- and 1.6-fold less in HS than in CON hearts respectively, p < 0.05. LVDP% was 60.3 (s.e.m., 6.3) for HS and 42.9 (4.1) for CON, p < 0.05. In summary, heat stress pretreatment improves postischaemic recovery of function in isolated rat hearts and this is associated with suppressed JNK activation in response to ischaemia-reperfusion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Reperfusion Injury  IEP 1582312 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapk8  (mitogen-activated protein kinase 8)


Additional Information