GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | arsenic trichloride results in increased phosphorylation of MAPK8 protein | PMID:22696236 PMID:24434654 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein] | PMID:22696236 | Mapk8 | multiple interactions | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | [arsenic trichloride co-treated with antimony trichloride] results in increased expression of MAPK8 mRNA; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of MAPK8 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein] | PMID:22696236 PMID:34091186 | | ||||||||||||||||||||||
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