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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTDcobaltous chloride results in increased phosphorylation of MAPK8 proteinPMID:21925238 PMID:22669716 PMID:31472278
Mapk8multiple interactionsEXP 6480464CTDiodopravadoline inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]; Protein Kinase Inhibitors inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]PMID:21925238 PMID:31472278
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDcobaltous chloride results in increased phosphorylation of MAPK8 proteinPMID:19101624 PMID:24386346
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]; ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]PMID:24386346
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