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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:4636
Term: diphenhydramine
Definition: An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Chemical ID: MESH:D004155
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases activityISOMAPK8 (Homo sapiens)6480464CTDDiphenhydramine results in increased activity of MAPK8PMID:17390763
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