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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases activityEXP 6480464CTDCadmium Chloride results in increased activity of MAPK8 proteinPMID:10637132
Mapk8increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of MAPK8 proteinPMID:18021293 PMID:21933187 PMID:23876460 PMID:31348969 PMID:31433112 PMID:35122928
Mapk8multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein; CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:15618353 PMID:20829427 PMID:21544200 PMID:21933187 PMID:31348969 PMID:31433112 PMID:34510229 PMID:34767868
Mapk8increases expressionISOMAPK8 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of MAPK8 protein modified formPMID:24419708
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of MAPK8 proteinPMID:10874044 PMID:16264267 PMID:18021293 PMID:19573589 PMID:21219922 PMID:21809093 PMID:35122928
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDCadmium Chloride results in increased phosphorylation of MAPK8 proteinPMID:11958953 PMID:18348256 PMID:34998821 PMID:36731763
Mapk8increases response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 protein results in increased susceptibility to Cadmium ChloridePMID:25374377
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MAPK8 protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; tin protoporphyrin IX inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:21219922 PMID:21544200 PMID:21809093 PMID:25374377 PMID:28949029 PMID:34510229 PMID:35122928
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased activity of MAPK8 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; LL Z1640-2 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MAP2K7 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MAPK8 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MT1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MT2 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Silymarin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; VDAC2 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]PMID:11958953 PMID:15081267 PMID:16728380 PMID:18348256 PMID:21544200 PMID:30796935 PMID:31271426 PMID:32199951 PMID:37261864
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