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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8affects expressionEXP 6480464CTDlead acetate affects the expression of MAPK8PMID:24293362
Mapk8increases expressionEXP 6480464CTDlead acetate results in increased expression of MAPK8 mRNAPMID:37471654
Mapk8increases phosphorylationEXP 6480464CTDlead acetate results in increased phosphorylation of MAPK8 proteinPMID:25088297
Mapk8multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK8 protein; Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK8 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK8 mRNA]PMID:20829427 PMID:25088297 PMID:35307918 PMID:37471654
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