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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8affects expressionISOMapk8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MAPK8 mRNAPMID:21570461
Mapk8affects response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 affects the susceptibility to TetrachlorodibenzodioxinPMID:9677421
Mapk8decreases expressionISOMapk8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MAPK8 mRNAPMID:19465110
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK8 proteinPMID:24469321
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK8 proteinPMID:20181658
Mapk8increases response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 results in increased susceptibility to TetrachlorodibenzodioxinPMID:9677421
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK8 protein]; KN 62 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK8 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK8 proteinPMID:16619036 PMID:24469321
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDMAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]; MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A4 protein]; MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF protein]PMID:20181658
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