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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:15891
Term: taurine
Definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
Chemical ID: MESH:D013654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8decreases expressionEXP 6480464CTDTaurine results in decreased expression of MAPK8 protein modified formPMID:27501764
Mapk8multiple interactionsEXP 6480464CTD[[Taurine binds to Zinc] which co-treated with poly(N-vinylpyrrolidine)] results in decreased expression of MAPK8 protein modified form; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased expression of MAPK8 mRNA]; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; [Taurine binds to Zinc] which results in decreased expression of MAPK8 mRNA; [Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK8 protein modified form; Taurine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]PMID:26335259 PMID:27501764
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