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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of MAPK8 proteinPMID:19072884
Mapk8increases activityEXP 6480464CTDsodium arsenite results in increased activity of MAPK8 proteinPMID:17658681
Mapk8increases expressionEXP 6480464CTDsodium arsenite results in increased expression of MAPK8 mRNA; sodium arsenite results in increased expression of MAPK8 proteinPMID:24497207 PMID:27966075 PMID:35259467
Mapk8increases phosphorylationEXP 6480464CTDsodium arsenite results in increased phosphorylation of MAPK8 proteinPMID:11408547 PMID:21621526 PMID:24952339
Mapk8multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK8 protein; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Galactose promotes the reaction [sodium arsenite results in increased expression of MAPK8 mRNA]; MAPK8 mutant form results in decreased susceptibility to [sodium arsenite co-treated with Cysteine deficiency co-treated with Methionine deficiency]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [sodium arsenite results in increased activity of MAPK8 protein]; p-coumaric acid inhibits the reaction [sodium arsenite results in increased expression of MAPK8 mRNA]; Vinyl Compounds analog inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA]PMID:11312036 PMID:17658681 PMID:20829427 PMID:21621526 PMID:24497207 PMID:24952339 PMID:27966075 PMID:35259467 PMID:35307918 PMID:36822304
Mapk8decreases expressionISOMAPK8 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of MAPK8 mRNAPMID:29301061
Mapk8decreases expressionISOMapk8 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of MAPK8 mRNAPMID:31233874
Mapk8increases activityISOMAPK8 (Homo sapiens)6480464CTDsodium arsenite results in increased activity of MAPK8 proteinPMID:22706169 PMID:23219847
Mapk8increases expressionISOMAPK8 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of MAPK8 protein modified formPMID:23219847
Mapk8increases expressionISOMapk8 (Mus musculus)6480464CTDsodium arsenite results in increased expression of MAPK8 mRNA; sodium arsenite results in increased expression of MAPK8 protein; sodium arsenite results in increased expression of MAPK8 protein modified formPMID:19822182 PMID:28757890 PMID:9671412
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of MAPK8 proteinPMID:12482858 PMID:19154403 PMID:21642427 PMID:21726611 PMID:24184208 PMID:26404762
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDsodium arsenite results in increased phosphorylation of MAPK8 proteinPMID:16973625 PMID:18996350 PMID:24184208 PMID:28843991 PMID:29854073 PMID:34272803
Mapk8increases response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 protein results in increased susceptibility to sodium arsenitePMID:21726611
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDMAPK8 mutant form inhibits the reaction [sodium arsenite results in increased expression of ELK1 mRNA]; MAPK8 protein affects the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; MAPK8 protein promotes the reaction [sodium arsenite results in increased expression of CCND1 protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased expression of CDK4 protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased phosphorylation of RB1 protein]; sodium arsenite promotes the reaction [MAPK8 protein binds to MAPK9 protein binds to TP53 protein modified form]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]PMID:21642427 PMID:21726611 PMID:22706169 PMID:26291278 PMID:26404762
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTD[MAPK8 protein mutant form results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] inhibits the reaction [sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased phosphorylation of MAPK8 protein; CDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Drugs, Chinese Herbal inhibits the reaction [sodium arsenite results in increased expression of MAPK8 mRNA]; Drugs, Chinese Herbal inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein modified form]; MAPK8 protein promotes the reaction [sodium arsenite results in increased activity of CASP3 protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased expression of GADD45A mRNA]; MAPK8 protein promotes the reaction [sodium arsenite results in increased expression of GADD45A protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of JUN protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK8 proteinPMID:16973625 PMID:20566634 PMID:23143138 PMID:25237887 PMID:28757890 PMID:29854073 PMID:33049506 PMID:34272803
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