Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 3870
Description: Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to mechanical stimulus; detection of stimulus involved in sensory perception of pain; and response to gold nanoparticle. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including alcohol use disorder; familial combined hyperlipidemia; kidney failure (multiple); liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (2E,4E)-hexa-2,4-dienoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tlr4m1Mcwi ; Tlr4em1Geh ; Tlr4em1Mcwi ; Tlr4em5Mcwi
Genetic Models: WI-Tlr4em1Geh ; FHH-Tlr4m1Mcwi ; BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi ; SS-Tlr4em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl585,161,192 - 85,175,007 (+)EnsemblGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)Ensemblrn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera579,045,293 - 79,058,928 (+)NCBICelera
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (IEP)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (IEP,IMP)
Acute Lung Injury  (IEP,IMP)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
alcohol dependence  (ISO)
alcohol use disorder  (IEP,ISO)
alcohol-associated liver disease  (ISO)
Alcohol-Related Disorders  (ISO)
alcoholic hepatitis  (IEP)
alcoholic liver cirrhosis  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Binge Drinking  (IEP,ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (IDA)
Chemical and Drug Induced Liver Injury  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (IMP)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (IDA,ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IDA,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial combined hyperlipidemia  (IEP,ISO)
familial Mediterranean fever  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fever  (IEP)
Fibrosis  (ISO)
Fungal Eye Infections  (IEP)
Fungal Keratitis  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (IEP)
Herpes Simplex Encephalitis  (IEP)
herpes simplex virus keratitis  (ISO)
hymenolepiasis  (IEP)
Hyperalgesia  (IMP,ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (IEP,ISO)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (ISO)
left ventricular failure  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (IEP,IMP,ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (IEP)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
middle cerebral artery infarction  (IEP)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IEP)
obesity  (IMP,ISO)
Ocular Onchocerciasis  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
Painful Neuropathy  (ISO)
pancreatitis  (IEP,ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO,ISS)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (IEP)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,IMP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP,ISO)
severe COVID-19  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (IMP)
sporotrichosis  (ISO)
squamous cell carcinoma  (ISO)
Stable Angina  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (IEP)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uric acid nephrolithiasis  (IEP)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (IEP)
Vibrio Vulnificus Infection  (IEP)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7alpha-hydroxycholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
afzelechin  (EXP)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldicarb  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alogliptin  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (ISO)
Alternaramide  (ISO)
aluminium hydroxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
anethole  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
aspalathin  (ISO)
astaxanthin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
baicalin  (EXP,ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
Besigomsin  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
Bisibuthiamine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boldenone  (EXP)
boric acid  (EXP)
bortezomib  (EXP,ISO)
bosentan  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cabazitaxel  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
Calcium propionate  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
catalpol  (ISO)
ceftaroline  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (EXP,ISO)
chromium atom  (ISO)
chrysin  (EXP,ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colistin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
DAPT  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dienogest  (ISO)
dihydrogen  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
embelin  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
erianin  (ISO)
eritoran  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
euxanthone  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
Fargesin  (ISO)
Fast green FCF  (ISO)
febuxostat  (EXP)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fosaprepitant  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
galangin  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
Gastrodin  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
halothane  (ISO)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
icariin  (EXP)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoamylol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
lactucin  (EXP)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
levocabastine  (ISO)
levofloxacin  (ISO)
lidocaine  (EXP)
linsidomine  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium chloride  (EXP)
lupeol  (ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
melphalan  (ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methadone  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
metronidazole  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (ISO)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (EXP,ISO)
Morroniside  (ISO)
muramyl dipeptide  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenol  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
omeprazole  (EXP)
Ondansetron  (EXP)
orlistat  (ISO)
oxaliplatin  (ISO)
oxybutynin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perampanel  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphoramide mustard  (EXP)
picropodophyllotoxin  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
propofol  (ISO)
protosappanin A  (EXP,ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
robinin  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP)
rutin  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 431542  (ISO)
scoparone  (ISO)
scopoletin  (EXP)
scutellarin  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium cholate  (EXP)
sodium propionate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP,ISO)
Timosaponin b ii  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (ISO)
Torularhodin  (ISO)
trans-anethole  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
tropisetron  (EXP)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Vinpocetine  (EXP)
vitamin D  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
astrocyte development  (ISO)
B cell proliferation involved in immune response  (ISO)
bone morphogenesis  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to mechanical stimulus  (IEA,IEP,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEP)
cellular response to type II interferon  (IEA,ISO)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IBA,ISO)
detection of lipopolysaccharide  (IBA,IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of stimulus  (IEA)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
gene expression  (ISO)
growth plate cartilage morphogenesis  (ISO)
I-kappaB phosphorylation  (ISO)
immune effector process  (IEA)
immune response  (IEA)
immune system process  (IEA)
immunoglobulin mediated immune response  (IEP)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA,ISO)
innate immune response-activating signaling pathway  (IMP)
intestinal epithelial structure maintenance  (IEA,ISO)
leukocyte activation  (IEA)
leukotriene metabolic process  (IDA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
macrophage activation  (IEA,ISO)
microglia differentiation  (ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-23 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
neurogenesis  (ISO)
nitric oxide production involved in inflammatory response  (ISO)
obsolete positive regulation of DNA-binding transcription factor activity  (IMP)
obsolete positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
phagocytosis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell migration  (IEA,IMP)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA binding  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-1 production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of matrix metallopeptidase secretion  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
regulation of dendritic cell cytokine production  (ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of tumor necrosis factor production  (IEA,IMP)
response to activity  (IEP)
response to bacterium  (ISO)
response to ethanol  (IEP,IMP)
response to fatty acid  (IDA)
response to glucocorticoid  (IEP)
response to gold nanoparticle  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IDA,IEP,ISO)
response to oxidative stress  (IMP)
response to progesterone  (IEP)
response to retinoic acid  (IEP)
response to toxic substance  (IEP)
signal transduction  (IEA)
skeletal muscle contraction  (IEP)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
toll-like receptor signaling pathway  (IDA,IEA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)
wound healing involved in inflammatory response  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. Abel B, etal., J Immunol. 2002 Sep 15;169(6):3155-62.
2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Algandaby MM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):419-28. doi: 10.1007/s00210-016-1210-1. Epub 2016 Jan 26.
4. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ali I, etal., Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.
5. Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. Alpay HC, etal., Auris Nasus Larynx. 2010 Feb;37(1):29-32. doi: 10.1016/j.anl.2009.03.001. Epub 2009 Apr 26.
6. Lack of association between Toll-like receptor 4 gene polymorphisms and giant cell arteritis. Alvarez-Rodriguez L, etal., Rheumatology (Oxford). 2011 Sep;50(9):1562-8. doi: 10.1093/rheumatology/ker168. Epub 2011 May 17.
7. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
8. Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels. Arjumand S, etal., Biomed Pharmacother. 2019 Mar;111:958-963. doi: 10.1016/j.biopha.2019.01.006. Epub 2019 Jan 9.
9. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
10. Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. Aumeunier A, etal., PLoS One. 2010 Jul 7;5(7):e11484.
11. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. Awomoyi AA, etal., J Immunol. 2007 Sep 1;179(5):3171-7.
12. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
13. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Bailey KL, etal., Alcohol Clin Exp Res. 2015 Sep;39(9):1691-7. doi: 10.1111/acer.12803. Epub 2015 Jul 24.
14. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
15. Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
16. Ischemia and reperfusion liver injury is reduced in the absence of Toll-like receptor 4. Ben-Ari Z, etal., Cell Physiol Biochem. 2012;30(2):489-98. doi: 10.1159/000341432. Epub 2012 Jul 13.
17. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
18. Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Bettoni I, etal., Glia. 2008 Sep;56(12):1312-9. doi: 10.1002/glia.20699.
19. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. Blanco AM, etal., J Immunol. 2005 Nov 15;175(10):6893-9.
20. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
21. Expression of Toll-like receptors in healthy and allergic conjunctiva. Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
22. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
23. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
24. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
25. Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes. Buraczynska M, etal., Hum Immunol. 2009 Feb;70(2):121-4. Epub 2009 Jan 7.
26. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Canale-Zambrano JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G381-90. Epub 2010 Jun 3.
27. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
28. Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis. Casale TB, etal., Ann Allergy Asthma Immunol. 2006 Oct;97(4):454-6.
29. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
30. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
31. TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
32. Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism. Chastain LG, etal., Neuropsychopharmacology. 2019 Aug;44(9):1579-1588. doi: 10.1038/s41386-019-0326-7. Epub 2019 Jan 30.
33. Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota. Chayanupatkul M, etal., BMC Complement Med Ther. 2022 Jun 22;22(1):168. doi: 10.1186/s12906-022-03643-9.
34. Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation. Chen C, etal., Shock. 2009 May;31(5):486-92.
35. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
36. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
37. [Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease]. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1584-8.
38. [Effect of compound qingqin liquid on the expression of toll-like receptor in the renal tissue of rats with urate nephropathy]. Chen Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jun;34(6):722-7.
39. Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model. Chi X, etal., Pulm Pharmacol Ther. 2013 Jun;26(3):380-7. doi: 10.1016/j.pupt.2013.02.001. Epub 2013 Feb 19.
40. Effect of Toll-like receptor 4 gene polymorphisms on work-related respiratory symptoms and sensitization to wheat flour in bakery workers. Cho HJ, etal., Ann Allergy Asthma Immunol. 2011 Jul;107(1):57-64. doi: 10.1016/j.anai.2011.04.003. Epub 2011 May 19.
41. Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Cho Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. doi: 10.1167/iovs.09-3688. Epub 2009 Jul 23.
42. Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis. Chung SH, etal., Clin Exp Immunol. 2011 May;164(2):275-81. doi: 10.1111/j.1365-2249.2011.04368.x. Epub 2011 Mar 10.
43. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
44. High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence. Crews FT, etal., Biol Psychiatry. 2012 Nov 30. pii: S0006-3223(12)00889-X. doi: 10.1016/j.biopsych.2012.09.030.
45. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
46. Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. de Oliveira JG and Silva AE, World J Gastroenterol. 2012 Mar 21;18(11):1235-42. doi: 10.3748/wjg.v18.i11.1235.
47. Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis. Deng YN and Zhou WB, Neuroimmunomodulation. 2007;14(6):337-43. Epub 2008 Apr 23.
48. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Deng ZB, etal., Diabetes. 2009 Aug 12.
49. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
50. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
51. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Ding N, etal., Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.
52. Effects of alcohol withdrawal on monocyte subset defects in chronic alcohol users. Donnadieu-Rigole H, etal., J Leukoc Biol. 2016 Nov;100(5):1191-1199. doi: 10.1189/jlb.5A0216-060RR. Epub 2016 Jun 2.
53. Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes. Du T, etal., Clin Chim Acta. 2009 Apr;402(1-2):133-8. Epub 2009 Jan 11.
54. Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
55. Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. Dvoriantchikova G, etal., Mol Vis. 2010 Sep 30;16:1907-12.
56. Significant correlation of TLR4 expression with the clinicopathological features of invasive ductal carcinoma of the breast. Ehsan N, etal., Tumour Biol. 2013 Apr;34(2):1053-9. doi: 10.1007/s13277-013-0645-y. Epub 2013 Jan 22.
57. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
58. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
59. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Etokebe GE, etal., Genet Test Mol Biomarkers. 2009 Dec;13(6):729-34. doi: 10.1089/gtmb.2009.0045.
60. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. Fageras Bottcher M, etal., J Allergy Clin Immunol. 2004 Sep;114(3):561-7.
61. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Fan J, etal., J Immunol 2002 May 15;168(10):5252-9.
62. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway. Feng PP, etal., Evid Based Complement Alternat Med. 2017;2017:6421260. doi: 10.1155/2017/6421260. Epub 2017 Jun 8.
63. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
64. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.
65. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
66. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. Freire D, etal., J Neuroimmune Pharmacol. 2019 Jun;14(2):263-277. doi: 10.1007/s11481-018-9816-3. Epub 2018 Oct 23.
67. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
68. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. Fuertes E, etal., J Allergy Clin Immunol. 2013 Aug;132(2):342-52.e2. doi: 10.1016/j.jaci.2013.03.007. Epub 2013 Apr 30.
69. Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Gagro A, etal., Clin Exp Immunol. 2004 Feb;135(2):267-72.
70. TLR4 mediates early graft failure after intraportal islet transplantation. Gao Q, etal., Am J Transplant. 2010 Jul;10(7):1588-96. doi: 10.1111/j.1600-6143.2010.03151.x.
71. [Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis]. Gao Y and Guo ZP, Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):655-7.
72. TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Garantziotis S, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):666-75. Epub 2009 Dec 10.
73. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
74. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
75. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
76. Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter. Gilmour PS, etal., Inhal Toxicol. 2004;16 Suppl 1:5-18.
77. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
78. Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. Grech I, etal., J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
79. Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-kappaB expression in rat mammary tissue. Gu B, etal., Int Immunopharmacol. 2010 Jul;10(7):799-805. doi: 10.1016/j.intimp.2010.04.022. Epub 2010 May 10.
80. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
81. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Gustot T, etal., Hepatology. 2006 May;43(5):989-1000. doi: 10.1002/hep.21138.
82. Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis. Halfhide CP, etal., Thorax. 2009 Sep;64(9):798-805. Epub 2009 Jun 3.
83. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Hammad H, etal., Nat Med. 2009 Apr;15(4):410-6. Epub 2009 Mar 29.
84. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
85. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
86. Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo. He D, etal., Int Immunopharmacol. 2016 Jun;35:201-209. doi: 10.1016/j.intimp.2016.03.032. Epub 2016 Apr 16.
87. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. He Z, etal., Respir Res. 2009 Dec 18;10:126.
88. Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Heimesaat MM, etal., Gut. 2007 Jul;56(7):941-8. Epub 2007 Jan 25.
89. Expression of toll-like receptors in chronic otitis media and cholesteatoma. Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
90. Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia. Hochhauser E, etal., PLoS One. 2013 Aug 15;8(8):e73041. doi: 10.1371/journal.pone.0073041. eCollection 2013.
91. Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction. Holloway JW, etal., Pharmacogenet Genomics. 2005 Jan;15(1):15-21.
92. Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Horie Y, etal., Rheumatology (Oxford). 2009 Jun;48(6):638-42. doi: 10.1093/rheumatology/kep077. Epub 2009 Apr 24.
93. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9.
94. Potential role of macrophages in experimental keratomycosis. Hu J, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2087-94. doi: 10.1167/iovs.07-1237. Epub 2008 Dec 13.
95. [Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases]. Hu ZJ, et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Jan;21(1):40-3.
96. Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. Hua J, etal., J Gastroenterol Hepatol. 2007 Jun;22(6):862-9. doi: 10.1111/j.1440-1746.2007.04896.x. Epub 2007 May 17.
97. [The role of expression of Toll-like receptor 2 and Toll-like receptor 4 in hyperoxia-induced acute lung injury in rat] Huang D, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Nov;21(11):644-7.
98. RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll‑like receptor 2/4 signaling pathways. Huang W, etal., Mol Med Rep. 2020 Aug;22(2):1373-1381. doi: 10.3892/mmr.2020.11242. Epub 2020 Jun 16.
99. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Huang X, etal., Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4910-6.
100. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
101. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Hutchinson MR, etal., Brain Behav Immun. 2008 Nov;22(8):1178-89. doi: 10.1016/j.bbi.2008.05.004. Epub 2008 Jul 2.
102. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Hutchinson MR, etal., Eur J Neurosci. 2008 Jul;28(1):20-9.
103. The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome. Illig T, etal., Diabetes. 2003 Nov;52(11):2861-4.
104. Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury. Impellizzeri D, etal., Immunobiology. 2015 Sep;220(9):1039-49. doi: 10.1016/j.imbio.2015.05.013. Epub 2015 May 11.
105. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Inokuchi S, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1509-18. doi: 10.1111/j.1530-0277.2011.01487.x. Epub 2011 Apr 4.
106. Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
107. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
108. Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. Jia L, etal., Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.
109. Inhibition of Toll-like receptor 4 with vasoactive intestinal peptide attenuates liver ischemia-reperfusion injury. Jiang W, etal., Transplant Proc. 2011 Jun;43(5):1462-7.
110. A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. Jiang ZC, etal., Tumour Biol. 2014 Dec;35(12):12345-52. doi: 10.1007/s13277-014-2547-z. Epub 2014 Sep 2.
111. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
112. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. Jilling T, etal., J Immunol. 2006 Sep 1;177(5):3273-82.
113. Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea. Jin X, etal., Cornea. 2007 Aug;26(7):847-52.
114. Expression of toll-like receptors in the Fusarium solani infected cornea. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
115. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
116. [Effects of intestinal trefoil factor on Toll-like receptors 2 and 4 expression in intestinal tissue in young rats with endotoxemia]. Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8.
117. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Jou I, etal., Am J Pathol. 2006 May;168(5):1619-30.
118. Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
119. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
120. Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques. Katsargyris A, etal., Expert Opin Ther Targets. 2010 Jan;14(1):1-10. doi: 10.1517/14728220903401294.
121. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
122. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
123. Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Kim K, etal., Clin Nutr. 2013 Oct;32(5):855-62. doi: 10.1016/j.clnu.2012.11.026. Epub 2013 Jan 23.
124. Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Kim SJ and Lee SM, Toxicol Appl Pharmacol. 2012 Jan 1;258(1):43-50. doi: 10.1016/j.taap.2011.10.005. Epub 2011 Oct 14.
125. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? Kim YM, etal., Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):921-7.
126. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
127. Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature. Kitagawa R, etal., Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G707-G715. doi: 10.1152/ajpgi.00372.2018. Epub 2019 Sep 11.
128. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
129. Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury. Kitazawa T, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1089-94. Epub 2009 Feb 15.
130. Salvage effect of E5564, Toll-like receptor 4 antagonist on d-galactosamine and lipopolysaccharide-induced acute liver failure in rats. Kitazawa T, etal., J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.
131. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
132. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
133. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Kolek MJ, etal., Am Heart J. 2004 Dec;148(6):1034-40.
134. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Koreck A, etal., Dermatology. 2006;213(3):267-9.
135. Hymenolepis diminuta: analysis of the expression of Toll-like receptor genes (TLR2 and TLR4) in the small and large intestines of rats. Kosik-Bogacka DI, etal., Exp Parasitol. 2012 Mar;130(3):261-6. doi: 10.1016/j.exppara.2011.12.002. Epub 2011 Dec 24.
136. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. Kuang X, etal., Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037. Epub 2011 Dec 7.
137. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
138. Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain. Kwilasz AJ, etal., Brain Behav Immun. 2021 Mar;93:80-95. doi: 10.1016/j.bbi.2020.12.016. Epub 2021 Jan 7.
139. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
140. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
141. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. Laflamme N and Rivest S, FASEB J. 2001 Jan;15(1):155-163.
142. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. Lartigue A, etal., J Immunol. 2009 Nov 15;183(10):6207-16. doi: 10.4049/jimmunol.0803219. Epub 2009 Oct 19.
143. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
144. Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. Leal SM Jr, etal., PLoS Pathog. 2010 Jul 1;6:e1000976. doi: 10.1371/journal.ppat.1000976.
145. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
146. [Polymorphism 896A/G of TLR4 gene rather than 1196C/T and 2258G/A of TLR2 gene determines severe and complicated course of atopic dermatitis in children]. Levchenko LIu, etal., Tsitol Genet. 2013 May-Jun;47(3):46-53.
147. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
148. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
149. Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Li H, etal., Anesthesiology. 2010 Sep;113(3):619-29.
150. Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury. Li HY, etal., Chin Med J (Engl). 2012 May;125(9):1586-93.
151. rhHMGB1 drives osteoblast migration in a TLR2/TLR4- and NF-kappaB-dependent manner. Li MJ, etal., Biosci Rep. 2016 Jan 7;36(1):e00300. doi: 10.1042/BSR20150239.
152. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
153. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
154. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
155. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
156. Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha. Liao P, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R599-607. Epub 2009 Dec 9.
157. Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
158. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. Lin M, etal., J Am Soc Nephrol. 2012 Jan;23(1):86-102. doi: 10.1681/ASN.2010111210. Epub 2011 Oct 21.
159. TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats. Lin ZP, etal., Mol Med Rep. 2020 Aug;22(2):651-660. doi: 10.3892/mmr.2020.11134. Epub 2020 May 7.
160. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
161. Changes in gut toll-like receptor-4 and nod-like receptor family pyrin domain containing-3 innate pathways in liver cirrhosis rats with bacterial translocation. Liu L, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):575-583. doi: 10.1016/j.clinre.2016.02.008. Epub 2016 Apr 6.
162. Insulin reduces LPS-induced lethality and lung injury in rats. Liu ML, etal., Pulm Pharmacol Ther. 2012 Dec;25(6):472-7. doi: 10.1016/j.pupt.2012.09.002. Epub 2012 Sep 13.
163. Tibia tumor-induced cancer pain involves spinal p38 mitogen-activated protein kinase activation via TLR4-dependent mechanisms. Liu S, etal., Brain Res. 2010 Jul 30;1346:213-23. Epub 2010 May 15.
164. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
165. Effect of antimicrobial agents on the toll-like receptors and inflammatory cytokines in liver tissue of the alcohol-induced liver disease in rats with Vibrio vulnificus sepsis. Lu ZQ, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1910-6.
166. [Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats] Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41.
167. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Lubbad A, etal., Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11.
168. Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma. Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
169. Ulinastatin post-treatment attenuates lipopolysaccharide-induced acute lung injury in rats and human alveolar epithelial cells. Luo Y, etal., Int J Mol Med. 2017 Feb;39(2):297-306. doi: 10.3892/ijmm.2016.2828. Epub 2016 Dec 13.
170. Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice. Luxameechanporn T, etal., Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):1001-6.
171. Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage. Ma CX, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1575-81.
172. The induced decrease in TLR2 and TLR4 by cerebrolysin in the alcoholic liver of rats. Mahmoudi J, etal., J Cell Physiol. 2019 Sep;234(9):16290-16294. doi: 10.1002/jcp.28293. Epub 2019 Feb 12.
173. The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4. Maldonado-Bernal C, etal., Parasite Immunol. 2005 Apr;27(4):127-37.
174. Differential expression of toll-like receptors 2 and 4 in patients with liver cirrhosis. Manigold T, etal., Eur J Gastroenterol Hepatol. 2003 Mar;15(3):275-82. doi: 10.1097/00042737-200303000-00011.
175. Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles. Mano SS, etal., Int J Mol Sci. 2013 Jun 26;14(7):13154-70. doi: 10.3390/ijms140713154.
176. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. Martin SF, etal., J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
177. Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin. Maslinska D, etal., Folia Neuropathol. 2004;42(3):125-32.
178. Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. Meguro A, etal., Ann Rheum Dis. 2008 May;67(5):725-7. doi: 10.1136/ard.2007.079871.
179. Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Methe H, etal., Circulation. 2005 May 24;111(20):2654-61. Epub 2005 May 9.
180. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
181. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
182. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
183. Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. Minmin S, etal., PLoS One. 2011 Apr 29;6(4):e19466. doi: 10.1371/journal.pone.0019466.
184. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Minoretti P, etal., Neurosci Lett. 2006 Jan 2;391(3):147-9. Epub 2005 Sep 12.
185. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
186. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
187. Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population. Najmi N, etal., Tissue Antigens. 2010 Aug;76(2):102-9. Epub 2010 Apr 8.
188. Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4. Nalamolu KR, etal., Neuroscience. 2018 Mar 1;373:82-91. doi: 10.1016/j.neuroscience.2018.01.014. Epub 2018 Jan 12.
189. Involvement of innate immunity in the pathogenesis of intestinal Behcet's disease. Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
190. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
191. Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation. Ohara K, etal., J Neuroinflammation. 2013 Nov 23;10:139. doi: 10.1186/1742-2094-10-139.
192. Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
193. S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Oliva J, etal., Exp Mol Pathol. 2011 Jun;90(3):239-43. doi: 10.1016/j.yexmp.2011.01.005. Epub 2011 Jan 25.
194. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
195. Association between toll-like receptor 4 gene polymorphism and biopsy-proven giant cell arteritis. Palomino-Morales R, etal., J Rheumatol. 2009 Jul;36(7):1501-6. doi: 10.3899/jrheum.081286. Epub 2009 Jun 16.
196. [Expression of toll-like receptors on CD14+ monocytes from patients with chronic obstructive pulmonary disease and smokers] Pan MM, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 5;88(30):2103-7.
197. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
198. Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis. Pasternak BA, etal., Inflamm Bowel Dis. 2010 May;16(5):856-69. doi: 10.1002/ibd.21132.
199. Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. Paulus SC, etal., Clin Immunol. 2007 Jun;123(3):252-7. Epub 2007 Apr 20.
200. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
201. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. Peng JH, etal., J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137. Epub 2012 Dec 31.
202. Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. Peng Y, etal., Surgery. 2008 May;143(5):679-85. doi: 10.1016/j.surg.2008.01.005.
203. Effects of gold nanoparticles on endotoxin-induced uveitis in rats. Pereira DV, etal., Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8036-41. doi: 10.1167/iovs.12-10743.
204. Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines. Pietrzak A, etal., Mediators Inflamm. 2011;2011:427473. doi: 10.1155/2011/427473. Epub 2011 May 2.
205. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
206. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Poggi M, etal., Diabetologia. 2007 Apr 11;.
207. Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. Powers KA, etal., J Exp Med. 2006 Aug 7;203(8):1951-61. Epub 2006 Jul 17.
208. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Prabha C, etal., Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
209. TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Puthothu B, etal., Dis Markers. 2006;22(5-6):303-8.
210. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
211. Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia. Reismann P, etal., J Neurol. 2004 Jul;251(7):853-8.
212. Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. Ren MY and Wu XY, Parasite Immunol. 2011 Jan;33(1):25-33. doi: 10.1111/j.1365-3024.2010.01247.x.
213. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Reyna SM, etal., Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.
214. GOA pipeline RGD automated data pipeline
215. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
216. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
217. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
218. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
219. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2004 Jan;27(1):179-83.
220. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
221. The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. Sackesen C, etal., Allergy. 2005 Dec;60(12):1485-92.
222. Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients. Sadik NA, etal., Arch Virol. 2015 Sep;160(9):2181-95. doi: 10.1007/s00705-015-2493-0. Epub 2015 Jun 23.
223. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
224. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
225. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3680-6. doi: 10.1167/iovs.09-4575. Epub 2010 Mar 5.
226. Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis. Sassa MF, etal., Immunology. 2009 Oct;128(2):301-9. doi: 10.1111/j.1365-2567.2009.03118.x.
227. Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
228. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Schmidt M, etal., Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.
229. Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy. Senthilselvan A, etal., Ann Allergy Asthma Immunol. 2008 May;100(5):463-8.
230. Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
231. TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
232. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
233. TLR4 links innate immunity and fatty acid-induced insulin resistance. Shi H, etal., J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.
234. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
235. Toll-like receptor 4 mediates lung ischemia-reperfusion injury. Shimamoto A, etal., Ann Thorac Surg. 2006 Dec;82(6):2017-23.
236. Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. Shirai Y, etal., J Gastroenterol Hepatol. 2013 Apr;28(4):723-30. doi: 10.1111/jgh.12112.
237. Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits. Shukla PK, etal., Alcohol. 2018 Dec;73:73-78. doi: 10.1016/j.alcohol.2018.04.004. Epub 2018 Apr 18.
238. Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway. Shyu KG, etal., J Biomed Sci. 2010 Mar 5;17:15.
239. [Differential expression of toll-like receptors in chronic suppurative otitis media and cholesteatoma]. Si Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):388-93.
240. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
241. Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. Singh K, etal., Biomed Res Int. 2013;2013:318686. doi: 10.1155/2013/318686. Epub 2013 Jul 11.
242. TLR4 and TLR9 are induced in oral lichen planus. Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
243. Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers. Speletas M, etal., Clin Dev Immunol. 2009;2009:260286. Epub 2010 Feb 15.
244. TLR2 and TLR4 polymorphisms in familial Mediterranean fever. Speletas M, etal., Hum Immunol. 2009 Sep;70(9):750-3. doi: 10.1016/j.humimm.2009.05.004. Epub 2009 May 13.
245. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. Stadlbauer V, etal., J Hepatol. 2008 Jun;48(6):945-51. Epub 2008 Mar 25.
246. Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4. Sturges NC, etal., Pediatr Pulmonol. 2010 Sep;45(9):883-9.
247. Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population. Suh W, etal., Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
248. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Summers SA, etal., Kidney Int. 2010 Sep 15.
249. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
250. A murine model of contact lens-associated fusarium keratitis. Sun Y, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1511-6. doi: 10.1167/iovs.09-4237. Epub 2009 Oct 29.
251. Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. Takano Y, etal., Am J Ophthalmol. 2012 Nov;154(5):825-832.e1. doi: 10.1016/j.ajo.2012.03.050. Epub 2012 Jul 24.
252. Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4. Takeuchi A, etal., Int Immunopharmacol. 2009 Dec;9(13-14):1562-7. doi: 10.1016/j.intimp.2009.09.012. Epub 2009 Sep 27.
253. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
254. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Tanga FY, etal., Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5856-61. Epub 2005 Apr 4.
255. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
256. Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis. Testro AG, etal., J Hepatol. 2010 Feb;52(2):199-205. doi: 10.1016/j.jhep.2009.11.006. Epub 2009 Dec 16.
257. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Theodoropoulos GE, etal., Breast. 2012 Aug;21(4):534-8. doi: 10.1016/j.breast.2012.04.001. Epub 2012 May 2.
258. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Tian J, etal., Cardiovasc Res. 2013 Jun 1;98(3):391-401. doi: 10.1093/cvr/cvt047. Epub 2013 Feb 27.
259. Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients. Tittarelli A, etal., Cancer Immunol Immunother. 2012 Nov;61(11):2067-77. doi: 10.1007/s00262-012-1268-7. Epub 2012 May 3.
260. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Tu CT, etal., Food Chem Toxicol. 2012 Sep;50(9):3343-51. doi: 10.1016/j.fct.2012.05.050. Epub 2012 Jun 7.
261. Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia. Tu XK, etal., Inflammation. 2011 Oct;34(5):463-70. doi: 10.1007/s10753-010-9254-8.
262. Curcumin inhibits TLR2/4-NF-κB signaling pathway and attenuates brain damage in permanent focal cerebral ischemia in rats. Tu XK, etal., Inflammation. 2014 Oct;37(5):1544-51. doi: 10.1007/s10753-014-9881-6.
263. Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. Tullos NA, etal., Curr Eye Res. 2013 Oct;38(10):1036-48. doi: 10.3109/02713683.2013.804094. Epub 2013 Jul 10.
264. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. Tuon FF, etal., J Dermatol Sci. 2010 Jul;59(1):55-7. doi: 10.1016/j.jdermsci.2010.04.009. Epub 2010 May 20.
265. Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease. Vainas T, etal., J Vasc Surg. 2006 Aug;44(2):326-32.
266. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
267. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
268. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
269. Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder. Vetreno RP, etal., Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.
270. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Vetreno RP, etal., Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15.
271. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Viriyakosol S, etal., Infect Immun. 2006 Feb;74(2):887-95.
272. [Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa]. Wang CS and Dong Z, Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.
273. [Changes and significance for regulatory factors for signal pathways of Toll-like receptors in immunological pathogenesis of Kawasaki disease]. Wang GB, etal., Zhonghua Er Ke Za Zhi. 2008 Jan;46(1):49-54.
274. Nuclear factor translocation and acute anterior uveitis. Wang J, etal., Mol Vis. 2011 Jan 18;17:170-6.
275. Association of TLR2 and TLR4 Gene Single Nucleotide Polymorphisms with Fungal Keratitis in Chinese Han Population. Wang N, etal., Curr Eye Res. 2014 Jan;39(1):47-52. doi: 10.3109/02713683.2013.827212. Epub 2013 Sep 27.
276. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Wang S, etal., Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.
277. Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. Wang XP, etal., PLoS One. 2015 Jul 30;10(7):e0134044. doi: 10.1371/journal.pone.0134044. eCollection 2015.
278. Host defense during Klebsiella pneumonia relies on hematopoietic expressed TLR4 and TLR2. Wieland CW, etal., Eur Respir J. 2010 Jul 22.
279. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. Wolfs TG, etal., J Immunol. 2002 Feb 1;168(3):1286-93.
280. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Wu FX, etal., Int J Med Sci. 2010 Aug 2;7(5):251-9.
281. Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis. Wu HS, etal., Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):609-13.
282. [Toll-like receptor 4 expression and cytokine secretion in microglial cells induced by IgG stimulation.] Wu R, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Mar;25(3):201-3.
283. [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide]. Wu YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Feb;32(2):111-4.
284. Differential expression of the CD14/TLR4 complex and inflammatory signaling molecules following i.c.v. administration of LPS. Xia Y, etal., Brain Res. 2006 Jun 20;1095(1):85-95. Epub 2006 May 12.
285. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6.
286. [Study on the expressions and roles of renal heat shock protein 72 and Toll-like receptor 4 in hepatorenal syndrome in rat] Yan CG, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Dec;19(12):731-4.
287. Streptozotocin-induced diabetic hyperalgesia in rats is associated with upregulation of Toll-like receptor 4 expression. Yan JE, etal., Neurosci Lett. 2012 Sep 20;526(1):54-8. doi: 10.1016/j.neulet.2012.08.012. Epub 2012 Aug 15.
288. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway. Yang C, etal., Stem Cells Int. 2020 Mar 26;2020:2134565. doi: 10.1155/2020/2134565. eCollection 2020.
289. Toll-like receptor 4 genetic variants and prognosis of breast cancer. Yang CX, etal., Tissue Antigens. 2013 Apr;81(4):221-6. doi: 10.1111/tan.12096.
290. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Yang IA, etal., Atherosclerosis. 2003 Sep;170(1):187-90.
291. Toll-like receptor 4-mediated hyper-responsiveness of gingival epithelial cells to lipopolysaccharide in high-glucose environments. Yang X, etal., J Periodontol. 2014 Nov;85(11):1620-8. doi: 10.1902/jop.2014.140087. Epub 2014 May 30.
292. Protective effect of bicyclol on liver injury induced by hepatic warm ischemia/reperfusion in rats. Yao XM, etal., Hepatol Res. 2009 Mar 10.
293. [Changes in Toll-like receptor 2 and 4 gene expression in vital organs in septic rats and their regulation mechanisms] Yao YM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Nov;15(11):646-50.
294. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Ye D, etal., Gut. 2012 Jul;61(7):1058-67. doi: 10.1136/gutjnl-2011-300269. Epub 2012 Jan 17.
295. The effects of baicalin on the TLR2/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model. Ye L, etal., Int Immunopharmacol. 2015 Mar;25(1):106-11. doi: 10.1016/j.intimp.2014.12.028. Epub 2015 Jan 6.
296. TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway. Yin Y, etal., Cell Physiol Biochem. 2017;42(2):469-479. doi: 10.1159/000477594. Epub 2017 Jun 5.
297. Toll-like receptor 4-deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension. Young KC, etal., Exp Lung Res. 2010 Mar;36(2):111-9.
298. Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats. Yu M, etal., Croat Med J. 2006 Dec;47(6):825-31.
299. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Yuan FF, etal., Immunol Cell Biol. 2008 Mar-Apr;86(3):268-70. Epub 2008 Jan 8.
300. Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory response. Zager RA, etal., Am J Physiol Renal Physiol. 2006 Sep;291(3):F546-56. Epub 2006 Apr 25.
301. Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle. Zanchi NE, etal., Eur J Appl Physiol. 2010 Aug;109(6):1095-102. Epub 2010 Apr 6.
302. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Zanotti G, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L52-63. Epub 2009 Apr 17.
303. Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Zareparsi S, etal., Hum Mol Genet. 2005 Jun 1;14(11):1449-55. Epub 2005 Apr 13.
304. Toll-like receptor 4 Asp299Gly gene polymorphism and risk of atherothrombosis. Zee RY, etal., Stroke. 2005 Jan;36(1):154-7. Epub 2004 Dec 2.
305. [Effect of nitric oxide on Toll-like receptor 2/4 gene expression in the liver in acute hemorrhagic necrotizing pancreatitis in rats] Zhang L, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Mar;18(3):161-4.
306. Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. Zhang P, etal., Brain Dev. 2015 Sep;37(8):747-52. doi: 10.1016/j.braindev.2014.12.001. Epub 2014 Dec 17.
307. Differential expression of Toll-like receptor pathway genes in chronic rhinosinusitis with or without nasal polyps. Zhang Q, etal., Acta Otolaryngol. 2013 Feb;133(2):165-73. doi: 10.3109/00016489.2012.717713. Epub 2012 Nov 19.
308. Toll-like receptor 4 deficiency causes pulmonary emphysema. Zhang X, etal., J Clin Invest. 2006 Nov;116(11):3050-9. Epub 2006 Oct 19.
309. TLR4 is a negative regulator in noninfectious lung inflammation. Zhao H, etal., J Immunol. 2010 May 1;184(9):5308-14. Epub 2010 Mar 31.
310. Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. Zheng Q, etal., Mediators Inflamm. 2021 Jul 14;2021:5571272. doi: 10.1155/2021/5571272. eCollection 2021.
311. Effects of Fufang Shenhua Tablet on the expression of toll-like receptors during acute kidney injury induced by ischemia-reperfusion in rats. Zheng XY, etal., Chin J Integr Med. 2012 Dec;18(12):918-24. doi: 10.1007/s11655-012-1295-1. Epub 2012 Dec 13.
312. The toll-like receptor 4-mediated signaling pathway is activated following optic nerve injury in mice. Zheng Z, etal., Brain Res. 2012 Dec 13;1489:90-7. doi: 10.1016/j.brainres.2012.10.014. Epub 2012 Oct 24.
313. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
314. Dectin1 activation of beta-(1-3)/(1-6)-D-glucan produces an anti-mastitis effect in rats. Zhu W, etal., Inflamm Res. 2011 Oct;60(10):937-45. doi: 10.1007/s00011-011-0354-1. Epub 2011 Jun 21.
315. Toll-like receptor-2 and -4 are associated with hyperlipidemia. Zhu YJ, etal., Mol Med Rep. 2015 Dec;12(6):8241-6. doi: 10.3892/mmr.2015.4465. Epub 2015 Oct 21.
Additional References at PubMed
PMID:10229796   PMID:10430608   PMID:10549626   PMID:10607756   PMID:10623794   PMID:10835634   PMID:10880523   PMID:11274165   PMID:11294571   PMID:11432859   PMID:11489994   PMID:11672593  
PMID:12055258   PMID:12594207   PMID:12824464   PMID:14599981   PMID:14691481   PMID:15027902   PMID:15334694   PMID:15356140   PMID:15661922   PMID:15712600   PMID:15737196   PMID:15793310  
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PMID:19734906   PMID:19740627   PMID:19824106   PMID:19852543   PMID:20016926   PMID:20021788   PMID:20037584   PMID:20043889   PMID:20051628   PMID:20107953   PMID:20113783   PMID:20127518  
PMID:20130368   PMID:20143470   PMID:20150961   PMID:20302880   PMID:20332628   PMID:20441697   PMID:20534845   PMID:20586888   PMID:20646617   PMID:20649597   PMID:20652722   PMID:20654065  
PMID:20665543   PMID:20670634   PMID:20717659   PMID:20945364   PMID:21109260   PMID:21151968   PMID:21186609   PMID:21227038   PMID:21248757   PMID:21329689   PMID:21343866   PMID:21368176  
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PMID:21878382   PMID:22002480   PMID:22053929   PMID:22067617   PMID:22086008   PMID:22097716   PMID:22207578   PMID:22233532   PMID:22246136   PMID:22288937   PMID:22381760   PMID:22392144  
PMID:22422608   PMID:22496605   PMID:22523073   PMID:22564590   PMID:22577135   PMID:22590866   PMID:22735756   PMID:22737905   PMID:22837686   PMID:22850250   PMID:22870324   PMID:22927965  
PMID:22957757   PMID:23040781   PMID:23050932   PMID:23059983   PMID:23082119   PMID:23116637   PMID:23141143   PMID:23146752   PMID:23155421   PMID:23165960   PMID:23171961   PMID:23280522  
PMID:23295061   PMID:23388509   PMID:23402995   PMID:23423259   PMID:23426570   PMID:23428594   PMID:23534838   PMID:23559285   PMID:23568774   PMID:23574173   PMID:23628899   PMID:23645013  
PMID:23656243   PMID:23691208   PMID:23790335   PMID:23791745   PMID:23812099   PMID:23817958   PMID:23840067   PMID:23844137   PMID:23861108   PMID:23874864   PMID:23884833   PMID:23970162  
PMID:23973554   PMID:23973924   PMID:23982744   PMID:24091496   PMID:24111943   PMID:24142717   PMID:24167596   PMID:24214856   PMID:24223475   PMID:24261962   PMID:24298017   PMID:24324707  
PMID:24423688   PMID:24428851   PMID:24429329   PMID:24472280   PMID:24499354   PMID:24573569   PMID:24582748   PMID:24587659   PMID:24601788   PMID:24612634   PMID:24660535   PMID:24667851  
PMID:24680857   PMID:24717912   PMID:24729619   PMID:24740015   PMID:24751148   PMID:24751828   PMID:24840167   PMID:24842692   PMID:24846408   PMID:24937603   PMID:25089018   PMID:25093580  
PMID:25103966   PMID:25106729   PMID:25108428   PMID:25169970   PMID:25171787   PMID:25204797   PMID:25223904   PMID:25318877   PMID:25342286   PMID:25343247   PMID:25359392   PMID:25400741  
PMID:25404055   PMID:25446875   PMID:25448126   PMID:25459886   PMID:25465639   PMID:25497689   PMID:25498891   PMID:25545945   PMID:25567426   PMID:25592618   PMID:25600901   PMID:25619390  
PMID:25652858   PMID:25695672   PMID:25732086   PMID:25738964   PMID:25772012   PMID:25780291   PMID:25783987   PMID:25810567   PMID:25811788   PMID:25821307   PMID:25826492   PMID:25853857  
PMID:25880347   PMID:25895164   PMID:25931256   PMID:25978623   PMID:25979559   PMID:25986658   PMID:26033363   PMID:26056446   PMID:26065826   PMID:26085359   PMID:26116862   PMID:26119193  
PMID:26229403   PMID:26279421   PMID:26290459   PMID:26312770   PMID:26390417   PMID:26434622   PMID:26436391   PMID:26465095   PMID:26477505   PMID:26510582   PMID:26556957   PMID:26585410  
PMID:26617842   PMID:26637556   PMID:26657742   PMID:26699475   PMID:26707779   PMID:26770978   PMID:26802935   PMID:26806574   PMID:26859874   PMID:26895894   PMID:26899371   PMID:26962463  
PMID:26966782   PMID:27031871   PMID:27057550   PMID:27107073   PMID:27107801   PMID:27187237   PMID:27193049   PMID:27279424   PMID:27318790   PMID:27412936   PMID:27413256   PMID:27431018  
PMID:27494109   PMID:27506813   PMID:27519154   PMID:27538408   PMID:27539497   PMID:27590301   PMID:27665434   PMID:27681173   PMID:27714571   PMID:27756052   PMID:27776340   PMID:27916733  
PMID:27922677   PMID:27956802   PMID:27981756   PMID:27986929   PMID:28033732   PMID:28096568   PMID:28098138   PMID:28272417   PMID:28291959   PMID:28306133   PMID:28359050   PMID:28410596  
PMID:28412141   PMID:28432060   PMID:28525945   PMID:28542370   PMID:28547529   PMID:28623271   PMID:28690033   PMID:28692063   PMID:28692940   PMID:28714001   PMID:28753906   PMID:28771774  
PMID:28808786   PMID:28827130   PMID:28855278   PMID:28946139   PMID:28978536   PMID:29039447   PMID:29113143   PMID:29115455   PMID:29142263   PMID:29193143   PMID:29215742   PMID:29222622  
PMID:29281615   PMID:29304519   PMID:29309503   PMID:29359143   PMID:29488614   PMID:29508184   PMID:29510084   PMID:29511370   PMID:29524303   PMID:29532872   PMID:29536648   PMID:29589070  
PMID:29627845   PMID:29656686   PMID:29682548   PMID:29749502   PMID:29845266   PMID:29845292   PMID:29907783   PMID:29940584   PMID:29944647   PMID:30031930   PMID:30032721   PMID:30046125  
PMID:30143913   PMID:30195636   PMID:30221655   PMID:30292407   PMID:30293084   PMID:30321456   PMID:30541949   PMID:30610955   PMID:30718548   PMID:30793463   PMID:30883606   PMID:30901719  
PMID:30953818   PMID:30978539   PMID:30980393   PMID:31002842   PMID:31096078   PMID:31173204   PMID:31220774   PMID:31256136   PMID:31288981   PMID:31318049   PMID:31376096   PMID:31391320  
PMID:31432123   PMID:31444671   PMID:31595494   PMID:31598849   PMID:31678414   PMID:31781182   PMID:31801411   PMID:31939007   PMID:31998444   PMID:32003057   PMID:32031699   PMID:32084554  
PMID:32124969   PMID:32160960   PMID:32214070   PMID:32240615   PMID:32259563   PMID:32270948   PMID:32396274   PMID:32667865   PMID:32777313   PMID:32865657   PMID:32926510   PMID:33039977  
PMID:33081813   PMID:33098506   PMID:33159115   PMID:33181267   PMID:33236160   PMID:33287126   PMID:33290148   PMID:33378037   PMID:33381567   PMID:33383282   PMID:33583793   PMID:33629321  
PMID:33629328   PMID:33730389   PMID:33744886   PMID:33855084   PMID:33900898   PMID:33909363   PMID:33962830   PMID:34032546   PMID:34051593   PMID:34142718   PMID:34260072   PMID:34296787  
PMID:34343528   PMID:34369678   PMID:34411492   PMID:34491653   PMID:34507068   PMID:34610358   PMID:34610452   PMID:34676874   PMID:34719837   PMID:34780278   PMID:34929310   PMID:34955133  
PMID:34964444   PMID:35070875   PMID:35163308   PMID:35217365   PMID:35294724   PMID:35322444   PMID:35609523   PMID:35820449   PMID:35860690   PMID:35865531   PMID:36073211   PMID:36360622  
PMID:36634215   PMID:36750423   PMID:36879557   PMID:36916435   PMID:37169474   PMID:37413932   PMID:37424158   PMID:37730152   PMID:37846082   PMID:37884783   PMID:37914064   PMID:37976699  
PMID:38095803   PMID:38195088   PMID:38299431   PMID:38403153   PMID:38788361   PMID:38850784  


Genomics

Comparative Map Data
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl585,161,192 - 85,175,007 (+)EnsemblGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)Ensemblrn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera579,045,293 - 79,058,928 (+)NCBICelera
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9117,704,175 - 117,724,735 (+)Ensemblhg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
T2T-CHM13v2.09129,898,286 - 129,918,621 (+)NCBIT2T-CHM13v2.0
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)Ensemblmm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)Ensembl
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21121,637,696 - 21,650,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1921,630,343 - 21,652,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19117,180,250 - 117,193,510 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)EnsemblpanPan2panpan1.1
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364876,518,441 - 6,533,095 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,058,970 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476017,598,630 - 17,609,120 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tlr4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1186,484,628 - 86,497,678 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tlr4
79 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:65
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000014020
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
PMC289161P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,544 - 80,158,848 (+)MAPPERmRatBN7.2
Rnor_6.0582,600,100 - 82,600,403NCBIRnor6.0
Rnor_5.0586,703,346 - 86,703,649UniSTSRnor5.0
RGSC_v3.4583,576,779 - 83,577,082UniSTSRGSC3.4
Celera579,057,972 - 79,058,275UniSTS
Cytogenetic Map5q24UniSTS
Tlr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,060 - 80,158,238 (+)MAPPERmRatBN7.2
Rnor_6.0582,599,616 - 82,599,793NCBIRnor6.0
Rnor_5.0586,702,862 - 86,703,039UniSTSRnor5.0
RGSC_v3.4583,576,295 - 83,576,472UniSTSRGSC3.4
Celera579,057,488 - 79,057,665UniSTS
RH 3.4 Map5643.7UniSTS
Cytogenetic Map5q24UniSTS


Genetic Models
This gene Tlr4 is modified in the following models/strains:
WI-Tlr4em1Geh     FHH-Tlr4m1Mcwi     BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi     SS-Tlr4em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 87 59 6 347 187 11 140 77 91 31 13 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF057025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU929065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ175880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014020   ⟹   ENSRNOP00000014020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl585,161,192 - 85,175,007 (+)Ensembl
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)Ensembl
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)Ensembl
RefSeq Acc Id: NM_019178   ⟹   NP_062051
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8585,161,247 - 85,174,882 (+)NCBI
mRatBN7.2580,145,867 - 80,159,501 (+)NCBI
Rnor_6.0582,587,424 - 82,601,056 (+)NCBI
Rnor_5.0586,690,670 - 86,704,302 (+)NCBI
RGSC_v3.4583,564,100 - 83,577,735 (+)RGD
Celera579,045,293 - 79,058,928 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062051 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC13313 (Get FASTA)   NCBI Sequence Viewer  
  ACI15385 (Get FASTA)   NCBI Sequence Viewer  
  ACS45118 (Get FASTA)   NCBI Sequence Viewer  
  EDM10505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014020
GenBank Protein Q9QX05 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42774 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42775 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42776 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42777 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42778 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42779 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42780 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42781 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42782 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42783 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42784 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42785 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42786 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42787 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42788 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42789 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42790 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42791 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42792 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42793 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42794 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42795 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42796 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42797 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42798 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42799 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42800 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42801 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42802 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42803 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42804 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42805 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42806 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42807 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42808 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42809 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42810 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42811 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42812 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42813 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42814 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42815 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42816 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42817 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42818 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42819 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42820 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42821 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42822 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42823 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42824 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42825 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42826 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42827 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42828 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42829 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42830 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42831 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42832 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42833 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42834 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42835 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42836 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42837 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42838 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42839 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42840 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42841 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42842 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42843 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42844 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42845 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42846 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42847 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42848 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42849 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42850 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42851 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42852 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42853 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42854 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42855 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42856 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42857 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42858 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42859 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42860 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42861 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42862 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42863 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42864 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42865 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42866 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42867 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42868 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42869 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42870 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42871 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42872 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42873 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42874 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42875 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42876 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42877 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42878 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42879 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42880 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42881 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42882 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42883 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42884 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42885 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42886 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42887 (Get FASTA)   NCBI Sequence Viewer  
  XAF83735 (Get FASTA)   NCBI Sequence Viewer  
  XAF83736 (Get FASTA)   NCBI Sequence Viewer  
  XAF83737 (Get FASTA)   NCBI Sequence Viewer  
  XAF83738 (Get FASTA)   NCBI Sequence Viewer  
  XAF83739 (Get FASTA)   NCBI Sequence Viewer  
  XAF83740 (Get FASTA)   NCBI Sequence Viewer  
  XAF83741 (Get FASTA)   NCBI Sequence Viewer  
  XAF83742 (Get FASTA)   NCBI Sequence Viewer  
  XAF83743 (Get FASTA)   NCBI Sequence Viewer  
  XAF83744 (Get FASTA)   NCBI Sequence Viewer  
  XAF83745 (Get FASTA)   NCBI Sequence Viewer  
  XAF83746 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062051   ⟸   NM_019178
- Peptide Label: precursor
- UniProtKB: G3V7D8 (UniProtKB/TrEMBL),   A6J802 (UniProtKB/TrEMBL),   A0A8K0ZPU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014020   ⟸   ENSRNOT00000014020
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX05-F1-model_v2 AlphaFold Q9QX05 1-835 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693807
Promoter ID:EPDNEW_R4332
Type:initiation region
Name:Tlr4_1
Description:toll-like receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0582,587,365 - 82,587,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3870 AgrOrtholog
BioCyc Gene G2FUF-41034 BioCyc
Ensembl Genes ENSRNOG00000010522 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014020 ENTREZGENE
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  TIR_dom UniProtKB/Swiss-Prot
  Toll-like_receptor UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29260 UniProtKB/Swiss-Prot
NCBI Gene 29260 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot
  TOLL-LIKE RECEPTOR 4 UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
PharmGKB TLR4 RGD
PhenoGen Tlr4 PhenoGen
PIRSF Toll-like_receptor UniProtKB/Swiss-Prot
PROSITE LRR UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010522 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF52200 UniProtKB/Swiss-Prot
TIGR TC233833
UniProt A0A8K0ZPU7 ENTREZGENE, UniProtKB/TrEMBL
  A6J802 ENTREZGENE, UniProtKB/TrEMBL
  B6DDJ8_RAT UniProtKB/TrEMBL
  C6KDV0_RAT UniProtKB/TrEMBL
  G3V7D8 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX05 ENTREZGENE, UniProtKB/Swiss-Prot
  U5LJ04_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tlr4  toll-like receptor 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is regulated by oxidant stress and lipopolysacchride, with oxidant stress inhibiting LPS-induced downregulation in expression 625648