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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4affects localizationEXP 6480464CTDLipopolysaccharides affects the localization of TLR4 proteinPMID:29375565
Tlr4decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of TLR4 mRNA; Lipopolysaccharides results in decreased expression of TLR4 proteinPMID:16309824 PMID:16651628
Tlr4increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of TLR4 mRNA; Lipopolysaccharides results in increased expression of TLR4 proteinPMID:12575980 PMID:17504260 PMID:21199063 PMID:21415432 PMID:21846543 PMID:22101700 PMID:24312512 PMID:24973090 PMID:25845602 PMID:27020608 PMID:30236991 PMID:31707400 PMID:32418911 PMID:33677747
Tlr4multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with sodium bisulfide] results in increased expression of TLR4 mRNA; [Lipopolysaccharides co-treated with sodium bisulfide] results in increased expression of TLR4 protein; [Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR4 mRNA; alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Formaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; Hydroxyethyl Starch Derivatives inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Lipopolysaccharides promotes the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Lipopolysaccharides promotes the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA]; platycodin D inhibits the reaction [Lipopolysaccharides affects the localization of TLR4 protein]; prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides promotes the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA]]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Sialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]PMID:17504260 PMID:21308757 PMID:21415432 PMID:21910595 PMID:22101700 PMID:23082119 PMID:24312512 PMID:24973090 PMID:25845602 PMID:27020608 PMID:29375565 PMID:30236991 PMID:31707400 PMID:32418911
Tlr4affects bindingISOTLR4 (Homo sapiens)6480464CTDLipopolysaccharides binds to [TLR4 protein binds to LY96 protein]; Lipopolysaccharides binds to TLR4 proteinPMID:22180778 PMID:26037075
Tlr4affects bindingISOTlr4 (Mus musculus)6480464CTDLipopolysaccharides binds to TLR4 proteinPMID:16678799 PMID:21148032 PMID:22849695 PMID:34029560
Tlr4affects response to substanceISOTLR4 (Homo sapiens)6480464CTDTLR4 protein mutant form affects the susceptibility to LipopolysaccharidesPMID:10835634
Tlr4affects response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 protein affects the susceptibility to LipopolysaccharidesPMID:11581577
Tlr4decreases activityISOTLR4 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased activity of TLR4 proteinPMID:25053413
Tlr4decreases expressionISOTLR4 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of TLR4 mRNA; Lipopolysaccharides results in decreased expression of TLR4 proteinPMID:12176910 PMID:20972769 PMID:21329777
Tlr4decreases expressionISOTlr4 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of TLR4 mRNA; Lipopolysaccharides results in decreased expression of TLR4 proteinPMID:16651628 PMID:25896969
Tlr4decreases response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 results in decreased susceptibility to Lipopolysaccharides analogPMID:22039958
Tlr4increases activityISOTLR4 (Homo sapiens)6480464CTDLipopolysaccharides results in increased activity of TLR4 proteinPMID:10835634 PMID:21255012 PMID:28003376
Tlr4increases activityISOTlr4 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of TLR4 proteinPMID:12848851 PMID:19627980 PMID:22344225 PMID:25780039
Tlr4increases expressionISOTLR4 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of TLR4 mRNA; Lipopolysaccharides results in increased expression of TLR4 proteinPMID:16317058 PMID:16443229 PMID:21729627 PMID:21933601 PMID:22314502 PMID:22429818 PMID:26037075 PMID:26497626 PMID:28390203 PMID:29128401 PMID:31059760 PMID:31935363 PMID:32017913 PMID:32612008 PMID:33677747 PMID:33930521 PMID:34655103 PMID:35608548 PMID:35774596 PMID:36055550 PMID:36350155
Tlr4increases expressionISOTlr4 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of TLR4 mRNA; Lipopolysaccharides results in increased expression of TLR4 proteinPMID:15665042 PMID:16864405 PMID:18306459 PMID:19136613 PMID:19433076 PMID:19540866 PMID:20054000 PMID:20972769 PMID:21108626 PMID:21352201 PMID:21963898 PMID:23170834 PMID:25171655 PMID:25342887 PMID:25500681 PMID:25843059 PMID:26141388 PMID:26540118 PMID:26620692 PMID:27568862 PMID:28096963 PMID:28177269 PMID:29441825 PMID:30225615 PMID:31299241 PMID:31350693 PMID:31654708 PMID:31707400 PMID:32687258 PMID:33140555 PMID:33285210 PMID:34029560 PMID:36807594 PMID:37177863 PMID:37182445 PMID:37269934 PMID:37477137
Tlr4increases localizationISOTlr4 (Mus musculus)6480464CTDLipopolysaccharides results in increased localization of TLR4 proteinPMID:21276822
Tlr4increases response to substanceISOTLR4 (Homo sapiens)6480464CTDTLR4 protein results in increased susceptibility to LipopolysaccharidesPMID:21383675
Tlr4increases response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 protein results in increased susceptibility to LipopolysaccharidesPMID:23000425
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD2,5-dimethyl-4-benzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; 2-tert-butyl-4-quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; 3-hydro-2,2,5,6-tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA; [Lipopolysaccharides results in decreased activity of TLR4 protein] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein]; [LY96 protein results in increased expression of TLR4 mRNA] which results in increased susceptibility to Lipopolysaccharides; [Proteoglycans co-treated with Progesterone] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; [Resveratrol co-treated with [Lipopolysaccharides binds to and results in increased activity of TLR4 protein]] results in decreased secretion of IL10 protein; [Resveratrol co-treated with [Lipopolysaccharides binds to and results in increased activity of TLR4 protein]] results in increased secretion of TNF protein; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]; Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]; curdlan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Fluorocarbons inhibits the reaction [Lipopolysaccharides results in increased secretion of TLR4 mRNA]; Lipopolysaccharides binds to and results in increased activity of TLR4 protein; Lipopolysaccharides inhibits the reaction [morphine-3-glucuronide results in increased activity of TLR4 protein]; Lipopolysaccharides promotes the reaction [TLR4 protein binds to ARHGEF2 protein]; Lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; monophosphoryl lipid A inhibits the reaction [USP18 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; phenylbenzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Resveratrol promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of TNF mRNA]; RIGI protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; RIGI protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; RIGI protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]]; RIGI protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Tin Fluorides inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; TLR4 affects the reaction [Lipopolysaccharides affects the localization of RELA protein]; TLR4 affects the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; TLR4 affects the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; TLR4 affects the reaction [Lipopolysaccharides results in increased localization of HIF1A protein]; TLR4 mRNA promotes the reaction [Lipopolysaccharides results in decreased expression of CTH protein]; TLR4 mutant form inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased activity of RHOA]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGEF2 protein]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; TLR4 protein affects the reaction [RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; TLR4 protein affects the reaction [RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; TLR4 protein affects the reaction [RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]]; TLR4 protein affects the reaction [RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; TLR4 protein inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [NEAT1 affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; TLR4 protein inhibits the reaction [NEAT1 affects the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; TLR4 protein inhibits the reaction [NEAT1 affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NFKBIA protein modified form]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of RELA protein modified form]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TRAF6 protein]; TLR4 protein promotes the reaction [Lipopolysaccharides results in increased expression of HRH1 mRNA]; USP18 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Zymosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]PMID:12574384 PMID:12734376 PMID:16317058 PMID:16443229 PMID:19833175 PMID:20700758 PMID:21255012 PMID:21329777 PMID:21616060 PMID:21933601 PMID:21956143 PMID:22014880 PMID:22087807 PMID:22226621 PMID:22314502 PMID:22429818 PMID:24035785 PMID:24967690 PMID:25053413 PMID:26497626 PMID:27183587 PMID:27385120 PMID:28390203 PMID:29128401 PMID:31059760 PMID:31935363 PMID:32017913 PMID:32612008 PMID:33677747 PMID:33930521 PMID:34655103 PMID:34673087 PMID:34687491 PMID:35774596 PMID:36055550 PMID:36350155
Tlr4multiple interactionsISOTlr4 (Mus musculus)6480464CTD2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; 3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]; 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 2,4,5,2',5'-pentachlorobiphenyl] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; [2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO1 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO2 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB1 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA; [Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of IL1B protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of IL6 protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of TNF protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased phosphorylation of NFKBIA protein; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein; [IGF1 protein co-treated with Lipopolysaccharides] results in decreased expression of TLR4 mRNA; [IL10 protein co-treated with Dexamethasone] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; [IL10 protein co-treated with TLR4 protein] affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB1 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB2 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of RELA protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ITGAX protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein; [Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TLR4 protein; [Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TLR4 protein; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TLR4 mRNA; [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNA; [Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein; [Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of NFKBIA protein; [Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein; [Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein; [Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA; [Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; [TLR4 co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides affects the activity of GSR protein]; [TLR4 gene mutant form co-treated with Lipopolysaccharides] results in increased expression of ALOX15 mRNA; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of GSR protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of MPO protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CRP protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CXCL15 protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFSF11 protein]]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides results in increased expression of CRP protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides results in increased expression of CXCL15 protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [TNFRSF1A protein co-treated with TLR4 protein] affects the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; ADIPOQ protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA]; ADIPOQ protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; apigenin-6,8-di-C-glycopyranoside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; APOA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TLR4 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; CRT 0066101 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; diallyl trisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; dorsomorphin inhibits the reaction [4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [Lipopolysaccharides results in increased localization of TLR4 protein]; goniothalamin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; HMOX1 protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA]; HMOX1 protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; IL1RL1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; IRAK2 protein promotes the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein results in decreased degradation of ZFP36 protein]]; kukoamine B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Lipopolysaccharides binds to and results in increased activity of TLR4 protein; Lipopolysaccharides inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]; Lipopolysaccharides promotes the reaction [TLR4 protein results in decreased degradation of ZFP36 protein]; morroniside inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; PCB 180 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of NFKBIA protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TLR4 protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; scolymoside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB2 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein]; timosaponin B-II inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]; TLR4 affects the reaction [Lipopolysaccharides results in decreased expression of CLEC10A mRNA]; TLR4 affects the reaction [Lipopolysaccharides results in increased expression of MST1R mRNA]; TLR4 affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 gene mutant form affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PCNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TLR4 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of ADAM17]; TLR4 mutant form promotes the reaction [Lipopolysaccharides results in increased phosphorylation of EGFR protein]; TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of GSR protein]; TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of MPO protein]; TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CRP protein]; TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CXCL15 protein]; TLR4 protein affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TLR4 protein affects the reaction [Lipopolysaccharides affects the activity of GSR protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of HJV mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased activity of MPO protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CRP protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL15 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IRF8 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNFSF11 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of GSR protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of MPO protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CRP protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CXCL15 protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides affects the activity of GSR protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of CRP protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL15 protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of TNFSF11 protein]]; TLR4 protein promotes the reaction [[Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; TLR4 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; TLR4 protein promotes the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein]; TLR4 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; TLR4 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]; TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of GSR protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] affects the activity of MPO protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CRP protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [[Lipopolysaccharides co-treated with IL10 protein] results in increased expression of CXCL15 protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides affects the activity of GSR protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CRP protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL15 protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNFSF11 protein]]PMID:11123339 PMID:16678799 PMID:16864405 PMID:17255318 PMID:17342418 PMID:17920563 PMID:18306459 PMID:19433076 PMID:19540866 PMID:19627980 PMID:20054000 PMID:20453108 PMID:20861358 PMID:20972769 PMID:21097750 PMID:21108626 PMID:21125213 PMID:21148032 PMID:21276822 PMID:21291324 PMID:21295571 PMID:21352201 PMID:21359540 PMID:21371294 PMID:21874253 PMID:21963898 PMID:22118570 PMID:22344225 PMID:22687552 PMID:22849695 PMID:22905218 PMID:23000425 PMID:23164921 PMID:23940812 PMID:25171655 PMID:25342887 PMID:25500681 PMID:25843059 PMID:26141388 PMID:26540118 PMID:26620692 PMID:27568862 PMID:28096963 PMID:28177269 PMID:30225615 PMID:31350693 PMID:31442584 PMID:31654708 PMID:31707400 PMID:32453893 PMID:32687258 PMID:33140555 PMID:33285210 PMID:34029560 PMID:36807594 PMID:37177863 PMID:37182445 PMID:37269934 PMID:37477137
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